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Your search keyword '"Imai, Takashi"' showing total 24 results
Start Over Author "Imai, Takashi" Publisher oxford university press (oup)
24 results on '"Imai, Takashi"'

2. Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

Author

Kerns, Sarah L, Fachal, Laura, Dorling, Leila, Barnett, Gillian C, Baran, Andrea, Peterson, Derick R, Hollenberg, Michelle, Hao, Ke, Narzo, Antonio Di, Ahsen, Mehmet Eren, Pandey, Gaurav, Bentzen, Søren M, Janelsins, Michelle, Elliott, Rebecca M, Pharoah, Paul D P, Burnet, Neil G, Dearnaley, David P, Gulliford, Sarah L, Hall, Emma, Sydes, Matthew R, Aguado-Barrera, Miguel E, Gómez-Caamaño, Antonio, Carballo, Ana M, Peleteiro, Paula, Lobato-Busto, Ramón, Stock, Richard, Stone, Nelson N, Ostrer, Harry, Usmani, Nawaid, Singhal, Sandeep, Tsuji, Hiroshi, Imai, Takashi, Saito, Shiro, Eeles, Rosalind, DeRuyck, Kim, Parliament, Matthew, Dunning, Alison M, Vega, Ana, Rosenstein, Barry S, West, Catharine M L, Wilson, Leila [0000-0003-1214-8080], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], and Apollo - University of Cambridge Repository

Subjects
Urologic Diseases, 0604 Genetics, Aging, Biomedical, Prevention, Prostate Cancer, Human Genome, Articles, Clinical Medicine and Science, Clinical Research, Genetics, 2.1 Biological and endogenous factors, 1112 Oncology and Carcinogenesis, Patient Safety, Cancer, Biotechnology
Abstract

Background A total of 10%–20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. Methods We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10−8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided. Results Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10−10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10−10), and rs11122573 with hematuria (Pmeta = 1.8 × 10−8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10−6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts. Conclusions This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile.

Published
2020

3. Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis

Author

Nishiyama, Kei, primary, Watanabe, Yuka, additional, Ishimura, Masataka, additional, Tetsuhara, Kenichi, additional, Imai, Takashi, additional, Kanemasa, Hikaru, additional, Ueki, Kenji, additional, Motomura, Yoshitomo, additional, Kaku, Noriyuki, additional, Sakai, Yasunari, additional, Imadome, Ken-Ichi, additional, and Ohga, Shouichi, additional

Published
2020
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4. Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

Author

Kerns, Sarah L, primary, Fachal, Laura, additional, Dorling, Leila, additional, Barnett, Gillian C, additional, Baran, Andrea, additional, Peterson, Derick R, additional, Hollenberg, Michelle, additional, Hao, Ke, additional, Narzo, Antonio Di, additional, Ahsen, Mehmet Eren, additional, Pandey, Gaurav, additional, Bentzen, Søren M, additional, Janelsins, Michelle, additional, Elliott, Rebecca M, additional, Pharoah, Paul D P, additional, Burnet, Neil G, additional, Dearnaley, David P, additional, Gulliford, Sarah L, additional, Hall, Emma, additional, Sydes, Matthew R, additional, Aguado-Barrera, Miguel E, additional, Gómez-Caamaño, Antonio, additional, Carballo, Ana M, additional, Peleteiro, Paula, additional, Lobato-Busto, Ramón, additional, Stock, Richard, additional, Stone, Nelson N, additional, Ostrer, Harry, additional, Usmani, Nawaid, additional, Singhal, Sandeep, additional, Tsuji, Hiroshi, additional, Imai, Takashi, additional, Saito, Shiro, additional, Eeles, Rosalind, additional, DeRuyck, Kim, additional, Parliament, Matthew, additional, Dunning, Alison M, additional, Vega, Ana, additional, Rosenstein, Barry S, additional, and West, Catharine M L, additional

Published
2019
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5. Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation

Author

Daino, Kazuhiro, primary, Ishikawa, Atsuko, additional, Suga, Tomo, additional, Amasaki, Yoshiko, additional, Kodama, Yotaro, additional, Shang, Yi, additional, Hirano-Sakairi, Shinobu, additional, Nishimura, Mayumi, additional, Nakata, Akifumi, additional, Yoshida, Mitsuaki, additional, Imai, Takashi, additional, Shimada, Yoshiya, additional, and Kakinuma, Shizuko, additional

Published
2019
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10. Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

Author

Maruyama, Reo, primary, Akino, Kimishige, additional, Toyota, Minoru, additional, Suzuki, Hiromu, additional, Imai, Takashi, additional, Ohe-Toyota, Mutsumi, additional, Yamamoto, Eiichiro, additional, Nojima, Masanori, additional, Fujikane, Tomoko, additional, Sasaki, Yasushi, additional, Yamashita, Toshiharu, additional, Watanabe, Yoshiyuki, additional, Hiratsuka, Hiroyoshi, additional, Hirata, Koichi, additional, Itoh, Fumio, additional, Imai, Kohzoh, additional, Shinomura, Yasuhisa, additional, and Tokino, Takashi, additional

Published
2008
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13. The ubiquitin–proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells

Author

Duan, Xuefeng, primary, Hisaeda, Hajime, additional, Shen, Jianying, additional, Tu, Liping, additional, Imai, Takashi, additional, Chou, Bin, additional, Murata, Shigeo, additional, Chiba, Tomoki, additional, Tanaka, Keiji, additional, Fehling, Hans Jörg, additional, Koga, Takaomi, additional, Sueishi, Katsuo, additional, and Himeno, Kunisuke, additional

Published
2006
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15. Radiosensitivity of Peripheral Blood Lymphocytes Obtained from Patients with Cancers of the Breast, Head and Neck or Cervix as Determined with a Micronucleus Assay

Author

BAN, Sadayuki, primary, KONOMI, Chika, additional, IWAKAWA, Mayumi, additional, YAMADA, Shigeru, additional, OHNO, Tatsuya, additional, TSUJI, Hiroshi, additional, NODA, Syuhei, additional, MATUI, Yoshifumi, additional, HARADA, Yoshinobu, additional, COLOGNE, John B., additional, and IMAI, Takashi, additional

Published
2004
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19. Changes in Epidermal Growth Factor Receptor and the Levels of its Ligands during Menstrual Cycle in Human Endometrium

Author

Imai, Takashi, primary, Kurachi, Hirohisa, additional, Adachi, Kazushige, additional, Adachi, Hiroshi, additional, Yoshimoto, Yasuhiro, additional, Homma, Hiroaki, additional, Tadokoro, Chikae, additional, Takeda, Suguru, additional, Yamaguchi, Masaaki, additional, Sakata, Masahiro, additional, Sakoyama, Yasuhiko, additional, and Miyake, Akira, additional

Published
1995
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22. Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy

Author

Kerns, Sarah L, Fachal, Laura, Dorling, Leila, Barnett, Gillian C, Baran, Andrea, Peterson, Derick R, Hollenberg, Michelle, Hao, Ke, Narzo, Antonio Di, Ahsen, Mehmet Eren, Pandey, Gaurav, Bentzen, Søren M, Janelsins, Michelle, Elliott, Rebecca M, Pharoah, Paul DP, Burnet, Neil G, Dearnaley, David P, Gulliford, Sarah L, Hall, Emma, Sydes, Matthew R, Aguado-Barrera, Miguel E, Gómez-Caamaño, Antonio, Carballo, Ana M, Peleteiro, Paula, Lobato-Busto, Ramón, Stock, Richard, Stone, Nelson N, Ostrer, Harry, Usmani, Nawaid, Singhal, Sandeep, Tsuji, Hiroshi, Imai, Takashi, Saito, Shiro, Eeles, Rosalind, DeRuyck, Kim, Parliament, Matthew, Dunning, Alison M, Vega, Ana, Rosenstein, Barry S, and West, Catharine ML

Subjects
Urologic Diseases, 0604 Genetics, Aging, Biomedical, Prevention, Prostate Cancer, Human Genome, 3. Good health, Clinical Medicine and Science, Clinical Research, FOS: Biological sciences, Genetics, 2.1 Biological and endogenous factors, 1112 Oncology and Carcinogenesis, Patient Safety, Cancer, Biotechnology
Abstract

BACKGROUND: A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. METHODS: We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided. RESULTS: Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10-10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10-10), and rs11122573 with hematuria (Pmeta = 1.8 × 10-8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts. CONCLUSIONS: This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile.

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