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Dear Sir, Infliximab is the only biological agent approved for the treatment of ulcerative colitis (UC).1 Its efficacy is only counterbalanced by the increased risk of severe infections and its own immunogenicity that may limit its applicability because of acute infusion reactions and loss of efficacy. Since most clinical data come from RCTs, there is limited experience with the use of infliximab among patients with UC and concomitant conditions that may increase the risk of infections. We report the case of a patient with alcoholic cirrhosis with portal hypertension, chronic pancreatitis, and ulcerative colitis treated with infliximab. A 45-year-old Caucasian male was admitted in our hospital because of a moderate acute flare of UC. He was a smoker and had been a heavy drinker until two years before, when he was diagnosed of alcoholic cirrhosis and portal hypertension because of his first ascites …