1. 4D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease
- Author
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Brett E. Fenster, Stephen M. Humphries, Kendall S. Hunter, Kurt R. Stenmark, Michal Schäfer, Vitaly O. Kheyfets, and J. Kern Buckner
- Subjects
Male ,medicine.medical_specialty ,Diastole ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Air trapping ,Sensitivity and Specificity ,Severity of Illness Index ,Statistics, Nonparametric ,Pulmonary Disease, Chronic Obstructive ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Image Interpretation, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Aged ,Analysis of Variance ,Heart Failure, Diastolic ,COPD ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Stroke Volume ,Magnetic resonance imaging ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,medicine.anatomical_structure ,030228 respiratory system ,Ventricle ,Case-Control Studies ,Heart failure ,Linear Models ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
AIMS: To investigate the possibility that vorticity assessed by four-dimensional flow cardiac magnetic resonance (4D-Flow CMR) in the left ventricle of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is a potential marker of early LV diastolic dysfunction (LVDD) and more sensitive than standard echocardiography, and whether changes in vorticity are associated with quantitative computed tomography (CT) and clinical markers of COPD, and right ventricular (RV) echocardiographic markers indicative of ventricular interdependency. METHODS AND RESULTS: Sixteen COPD patients with presumptive LVDD and 10 controls underwent same-day 4D-Flow CMR and Doppler echocardiography to quantify early and late diastolic vorticity as well as standard evaluation for LVDD. Furthermore, all patients underwent detailed CT analysis for COPD markers including percent emphysema and air trapping. The 4D-Flow CMR derived diastolic vorticity measures were correlated with CT measures, standard clinical and CMR markers, and echocardiographic diastolic RV metrics. Early diastolic vorticity was significantly reduced in COPD patients (P
- Published
- 2017
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