1. Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
- Author
-
Morgan H. James, Douglas W. Smith, Janine L. Charnley, Jiann Wei Yeoh, Christopher V. Dayas, Emma Jones, and Emily M. Levi
- Subjects
Male ,Receptors, Neuropeptide ,Self Administration ,Motor Activity ,Nucleus accumbens ,Extinction, Psychological ,Receptors, G-Protein-Coupled ,Rats, Sprague-Dawley ,Cocaine-Related Disorders ,Cocaine ,Dopamine Uptake Inhibitors ,Thalamus ,Orexin Receptors ,Dopamine ,mental disorders ,medicine ,Animals ,Urea ,Pharmacology (medical) ,Naphthyridines ,Receptor ,Pharmacology ,Benzoxazoles ,musculoskeletal, neural, and ocular physiology ,Ventral Tegmental Area ,Antagonist ,Rats ,Orexin ,Blockade ,Ventral tegmental area ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,Paraventricular thalamus ,Cues ,Psychology ,Neuroscience ,psychological phenomena and processes ,medicine.drug - Abstract
Orexinergic signalling is critical to drug relapse-like behaviour ; however, the CNS sites(s) of action remain unknown. Two candidate brain regions are the paraventricular thalamus (PVT) and ventral tegmental area (VTA). We assessed the effect of intra-PVT or -VTA administration of the orexin-1 receptor (OrxR1) antagonist SB-334867 on discriminative cue-induced cocaine-seeking. Animals received either PVT- or VTA-directed SB-334867 (0, 3 or 6 m g; 0, 1 or 3mg, respectively) prior to reinstatement testing elicited by presenting cocaine-paired stimuli (S + ). The effect of VTA-directed injections of SB-334867 (0 or 3 mg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S + -induced reinstatement (3 mg dose, p
- Published
- 2011
- Full Text
- View/download PDF