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BACKGROUND: The Electronic Integrated Text, Visual and Audio Questionnaire (EITVAQ) was designed towards developing a disease-specific tool to measure child health status from a child’s perspective. EITVAQ’s outcome is anticipated to be positive, introducing a child-friendly health measurement tool. METHODS: This was a prospective crossover pilot study that compared EITVAQ to a printed text 2-paged paper questionnaire (TEXT) format quality of life questionnaire in paediatric hydrocephalus patients. The study was conducted from November 2015 to June 2016 in the Neurosurgical Outpatient Department, Temple Street, Children University Hospital. Data was compiled for both EITVAQ and TEXT and analyzed using Software Package using Statistical Analysis (SPSS). FINDINGS: There was a 100% rate of completion for EITVAQ. However, only 9 (37.5%) of the patients managed to complete the text format. The mean time to complete EITVAQ was 7 minutes. There are 32 questions found in EITVAQ. The mean score for EITVAQ was 132.92 (83%) satisfactory score. Using Pearson Chi-Square Test, the P-Value is 0.341. Although this is not a significantly substantial value, however, patient with less surgical procedure were able to complete EITVAQ 18.9% more than patient with more than 5 surgical procedures. Furthermore, there was no real correlation between the gross motor function classification system (GMFCS) score and the inability to complete the TEXT format. CONCLUSIONS: In this study, the results support that EITVAQ is a better tool to evaluate the health status of paediatric hydrocephalus patients as it is tailored according to their disability needs.

The authors report a case of high-grade glioma with unusual pathology that has not previously been reported in glioma pathology. The 5-year-old patient presented to the emergency department with a 1-day history of a right temporal swelling on a background history of increasing nausea and vomiting for the preceding 5 months. A computed tomography brain was performed, which showed a large right-sided temporoparietal lesion. The patient underwent surgery to remove the mass and pathology confirmed anaplastic astrocytoma (WHO Grade 3). This report focuses on prognostic factors in high-grade glioma, particularly on pathological indicators, namely epidermal growth factor receptor, O6-methylguanine-DNA-methyltransferase expression and BRAF V600D mutation.

LG-48. PAEDIATRIC LOW GRADE GLIOMAS IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT Noelle Cullinan1, John Caird2, Michael Capra1, Jane Pears1, Cormac Owens1, andDarachCrimmins2; DepartmentofHaematology/Oncology,Our Lady’s Children’s Hospital, Dublin, Ireland; Department of Paediatric Neurosurgery, Children’s University Hospital, Temple Street, and Beaumont Hospital, Dublin, Ireland AIMS: Completely excised paediatric low grade gliomas (LGGs) are associated with excellent survival rates. Complete resection is not always achievable. We reviewed the Irish neurosurgical experience of paediatric LGGs over a 10-year period. METHODS: We performed a retrospective review of all paediatric patients with LGG diagnosed in the Republic of Ireland between 2005-2014. RESULTS: 112 children were diagnosed over a 10-year period (52 male (46%), 60 female (53%), Age range 0.23–15.87 years, Mean 7.03 years, Median 6.3 years). 111 children had surgical procedures – 14 (13%) had biopsies alone, 16 (14%) had biopsies followed by later resections, while 79 (71%) had upfront craniotomies with resection. We were unable to identify the type of procedure in 2 children. 1 child had a radiological diagnosis of aLGG but no confirmatorybiopsy.79 patientshadupfront craniotomies. In 77/79, all required information was available. 40/77 (52%) had Gross Total Resection (GTR) confirmed by post-operative imaging and 37/77 (48%) had incomplete resections. Of those who had GTR confirmed (excluding patients with Neurofibromatosis Type 1), 3 patients (4%) relapsed or had disease progression in follow-up, with early progression noted, all within 15 months after resection. All others are currently disease free in follow up (96%). CONCLUSION: In those with confirmed GTR on post-operative imaging, recurrence, if it occurred, was early. We propose that scanning intervals can be increased after 2 years and ongoing need for imaging surveillance in those with confirmed GTR should be reviewed. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.48 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.