Search

Your search keyword '"MESH: Infant, Newborn"' showing total 5 results
Start Over Descriptor "MESH: Infant, Newborn" Publisher oxford university press (oup)
5 results on '"MESH: Infant, Newborn"'

1. Chronic Granulomatous Disease in Patients Reaching Adulthood: A Nationwide Study in France

Author

Julie Bardet, Olivier Hermine, Fanny Lanternier, Nicolas Noel, Isabelle Durieu, Agathe Masseau, Olivier Lortholary, Felipe Suarez, Jacinta Bustamante, Bertrand Dunogue, Hélène Salvator, Benoit Pilmis, Marie-Anne Gougerot-Pocidalo, Stéphane Blanche, Fanny Fouyssac, Nizar Mahlaoui, Marc Lecuit, Harry Sokol, Emilie Catherinot, Vincent Barlogis, Caroline Elie, Alain Fischer, Louis-Jean Couderc, Hélène Coignard-Biehler, Karima Amazzough, Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département d'Immunologie, hématologie et rhumatologie pédiatriques [Hôpital Necker-Enfants malades - APHP], CHU Necker - Enfants Malades [AP-HP], Génétique Humaine des Maladies Infectieuses (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'informatique médicale et biostatistiques [CHU Necker], Université Paris Descartes - Paris 5 (UPD5), Service de pneumologie [Hôpital Foch], Hôpital Foch [Suresnes], Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hématologie et d'Oncologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Onco-Hématologie Pédiatrique [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University [New York], Service d'hématologie et immunologie, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Service de Pédiatrie et Hématologie Pédiatrique [CHU Timone, AP-HM], Hôpital de la Timone [CHU - APHM] (TIMONE), Service de médecine interne, Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de médecine interne et de pathologie vasculaire [hôpital Lyon sud, HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Microorganismes et Barrières de l'Hôte (Equipe avenir), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hématologie Adulte, Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications (ERL 8254 - Equipe Inserm U1163), Chaire Médecine expérimentale (A. Fischer), Collège de France (CdF (institution)), Service d'immuno-hématologie pédiatrique [CHU Necker], The CEREDIH is supported by the French Association of Patients with Primary Immunodeficiencies and is funded by the French Ministry of Health. It additionally received unrestricted educational grants from Behring, Baxalta, Octapharma, and the patient associations AT-Europe and Trophée Guillaume., We thank all clinicians of the French national Centre de Référence des Déficits Immunitaires Héréditaires (CEREDIH) network for their help with this study. We also thank the CEREDIH staff: Chantal Andriamanga, Carolina Brito, Laurence Costes, Virginie Courteille, and Nathalie Devergnes., Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de pédiatrie, d'hématologie et d'oncologie [Hôpital de La Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collège de France - Chaire Médecine expérimentale (A. Fischer), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pneumologie [Hôpital Foch, Suresnes], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), St Giles laboratory of Human Genetics and Infectious Diseases, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Equipe avenir Microorganismes et Barrières de l'Hôte, and Collège de France (CdF)

Subjects
Male, 0301 basic medicine, Pediatrics, MESH: Registries, [SDV]Life Sciences [q-bio], medicine.medical_treatment, MESH: Granulomatous Disease, Chronic/diagnosis, Autoimmunity, Hematopoietic stem cell transplantation, chronic granulomatous disease, MESH: Granulomatous Disease, Chronic/complications, Granulomatous Disease, Chronic, 0302 clinical medicine, Chronic granulomatous disease, Cost of Illness, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, MESH: Bacterial Infections/etiology, MESH: Bacterial Infections/prevention & control, Registries, 030212 general & internal medicine, Child, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, High rate, MESH: France/epidemiology, MESH: Granulomatous Disease, Chronic/epidemiology, MESH: Bacterial Infections/epidemiology, MESH: Infant, Newborn, Age Factors, MESH: Mycoses/epidemiology, transition, Bacterial Infections, sequelae, MESH: Cost of Illness, MESH: Infant, Adult height, 3. Good health, Phenotype, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, Child, Preschool, Population Surveillance, MESH: Mycoses/drug therapy, MESH: Survival Analysis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, France, Symptom Assessment, Microbiology (medical), medicine.medical_specialty, adulthood, Adolescent, MESH: Mycoses/prevention & control, primary immunodeficiency, MESH: Phenotype, MESH: Population Surveillance, 03 medical and health sciences, MESH: Cross-Sectional Studies, MESH: Antibiotic Prophylaxis, MESH: Autoimmunity, MESH: Mycoses/etiology, medicine, Humans, In patient, MESH: Bacterial Infections/drug therapy, Retrospective Studies, MESH: Adolescent, MESH: Age Factors, MESH: Humans, business.industry, MESH: Symptom Assessment, MESH: Granulomatous Disease, Chronic/mortality, MESH: Child, Preschool, Infant, Newborn, Infant, MESH: Retrospective Studies, Retrospective cohort study, Antibiotic Prophylaxis, medicine.disease, Survival Analysis, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, Cross-Sectional Studies, 030104 developmental biology, Mycoses, Respiratory failure, Primary immunodeficiency, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background : Although prognosis of Chronic Granulomatous Disease (CGD) has greatly improved, few studies have focused on its long-term outcome. We studied the clinical course and sequelae of CGD patients diagnosed before age 16, at various adult time points. Method : Cross-sectional French nationwide retrospective study of patients screened through the National Reference Center for Primary Immunodeficiencies (CEREDIH) registry. Results : Eighty CGD patients (71 males [88.7%], 59 X-linked [73.7%], median age 23.9 years [minimum, 16.6; maximum, 59.9]) were included, Median ages at diagnosis and last follow-up were 2.52 and 23.9 years, respectively. Seven patients underwent hematopoietic stem cell transplantation. A total of 553 infections requiring hospitalization occurred in 2017 patient-years. The most common site of infection was pulmonary (31%). Aspergillus spp. (17%) and Staphylococcus aureus (10.7%) were the commonest pathogens. A total of 224 inflammatory episodes occurred in 71 patients, mainly digestive (50%). Their characteristics as well as their annual frequency did not vary before and after age 16. Main sequelae were a small adult height and weight and mild chronic restrictive respiratory failure. At age 16, only 53% of patients were in high school. After age 30 years, 9/13 patients were working. Ten patients died during adulthood. Conclusions : Adult CGD patients displayed similar characteristics and rates of severe infections and inflammatory episodes that those of childhood. The high rate of handicap has become a matter of medical and social consideration. Careful follow-up in centers of expertise is strongly recommended and an extended indication of curative treatment by HSCT should be considered.

Published
2017
Full Text
View/download PDF

2. Performance of Xpert MTB/RIF and Alternative Specimen Collection Methods for the Diagnosis of Tuberculosis in HIV-Infected Children

Author

Sara Eyangoh, Sophie Goyet, Arnaud Tarantola, Christophe Delacourt, Mathurin Cyrille Tejiokem, Abdoul-Salam Ouedraogo, Sokleaph Cheng, Laurence Borand, Boubacar Nacro, Sylvain Godreuil, Stéphane Blanche, Thu Hang Pham, Vibol Ung, Olivier Marcy, Philippe Msellati, Ngoc Lan Nguyen Thi, Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Pediatric Hospital, University of Health Sciences – Cambodia, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Pham Ngoc Thach Hospital, Centre Hospitalier Universitaire Souro Sanou [Bobo-Dioulasso] (CHUSS), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Necker - Enfants Malades [AP-HP], and This work was supported by the French National Institute for Health and Medical Research (Inserm)–ANRS (ANRS 12194, ANRS 12229) and Fondation Total.

Subjects
Male, Bodily Secretions, MESH: Mycobacterium tuberculosis, diagnosis, HIV Infections, MESH: Bodily Secretions, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Nasopharyngeal aspirate, MESH: Child, Xpert MTBRIF, Medicine, MESH: Tuberculosis, Cameroon, 030212 general & internal medicine, Child, education.field_of_study, biology, Coinfection, MESH: Infant, Newborn, MESH: HIV Infections, MESH: Infant, 3. Good health, Infectious Diseases, tuberculosis, Vietnam, Specimen collection, Child, Preschool, Female, medicine.symptom, Cambodia, Nucleic Acid Amplification Techniques, DNA, Bacterial, Microbiology (medical), medicine.medical_specialty, Tuberculosis, Adolescent, Xpert MTB/RIF, Population, Sensitivity and Specificity, Specimen Handling, MESH: Nucleic Acid Amplification Techniques, Mycobacterium tuberculosis, 03 medical and health sciences, children, Tuberculosis diagnosis, 030225 pediatrics, Internal medicine, Burkina Faso, parasitic diseases, Humans, MESH: Burkina Faso, MESH: Specimen Handling, education, MESH: Adolescent, MESH: Humans, business.industry, MESH: Cambodia, MESH: Child, Preschool, Infant, Newborn, Infant, Nucleic acid amplification technique, MESH: Cameroon, HIV infection, biology.organism_classification, medicine.disease, MESH: DNA, Bacterial, MESH: Male, MESH: Sensitivity and Specificity, MESH: Coinfection, Surgery, Sputum, MESH: Vietnam, business, MESH: Female
Abstract

International audience; BACKGROUND:The diagnosis of tuberculosis in human immunodeficiency virus (HIV)-infected children is challenging. We assessed the performance of alternative specimen collection methods for tuberculosis diagnosis in HIV-infected children using Xpert MTB/RIF (Xpert).METHODS:HIV-infected children aged ≤13 years with suspected intrathoracic tuberculosis were enrolled in 8 hospitals in Burkina Faso, Cambodia, Cameroon, and Vietnam. Gastric aspirates were taken for children aged

Published
2016
Full Text
View/download PDF

3. Multilocus sequence typing for the analysis of clonality among Candida albicans strains from a neonatal intensive care unit

Author

Soo Hyun Kim, Hee-Chang Jang, Jong Hee Shin, Young Youn Choi, Christophe d'Enfert, Eun Song Song, Marie-Elisabeth Bougnoux, Min Ji Choi, Chonnam National University [Gwangju], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie et Pathogénicité fongiques, Institut Pasteur [Paris]-Institut National de la Recherche Agronomique (INRA), Université Paris Descartes - Paris 5 (UPD5), This work was supported by a Chonnam National University Hospital Research Institute of Clinical Medicine grant (CRI11082) and a grant from the French and Korean Ministries for Foreign Affairs (PHC STAR 2011 25841YA)., Biologie et Pathogénicité fongiques (BPF), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris], and Institut National de la Recherche Agronomique (INRA) - Institut Pasteur [Paris]

Subjects
Male, multilocus sequence typing, MESH: Genotype, Candida albicans, Genotype, Mycological Typing Techniques, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Genetics, Molecular Epidemiology, 0303 health sciences, biology, MESH: Infant, Newborn, Candidiasis, General Medicine, MESH: Infant, MESH: Candidiasis, Corpus albicans, Electrophoresis, Gel, Pulsed-Field, 3. Good health, MESH: Multilocus Sequence Typing, MESH: Electrophoresis, Gel, Pulsed-Field, Infectious Diseases, pulsed-field gel electrophoresis, Female, Locus (genetics), MESH: Disease Transmission, Infectious, Microbiology, 03 medical and health sciences, Intensive Care Units, Neonatal, MESH: Mycological Typing Techniques, Intensive care, Disease Transmission, Infectious, Pulsed-field gel electrophoresis, Humans, MESH: Molecular Epidemiology, Genotyping, 030304 developmental biology, MESH: Humans, 030306 microbiology, MESH: Candida albicans, Infant, Newborn, Infant, bacterial infections and mycoses, biology.organism_classification, [SDV.MP.MYC] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, neonatal intensive care unit, MESH: Male, genotyping, Multilocus sequence typing, MESH: Female, MESH: Intensive Care Units, Neonatal
Abstract

International audience; Nosocomial Candida albicans infections are a significant problem in neonatal intensive care units (NICUs). We investigated the clonality of C. albicans isolates recovered over an 8-year period from neonates at a NICU. We also validated multilocus sequence typing (MLST) compared with pulsed-field gel electrophoresis (PFGE) for the genotyping of C. albicans strains from the same NICU. A total of 43 clinical isolates (10 blood, 19 urine, and 14 other) were obtained from 43 neonates between 2005 and 2012. Clonal strains were defined as the isolation of two or more strains with identical or similar genotypes as determined with both MLST and PFGE. Using MLST, the 43 isolates yielded 25 diploid sequence types (DSTs) and 10 DSTs were shared by 28 isolates (65.1%). Among the 28 isolates sharing 10 DSTs, isolates from each of seven DSTs had the same or similar PFGE pattern. In addition, two sets of isolates that differed by MLST at only one locus had the same or similar PFGE pattern. Overall, when the MLST and PFGE results were combined, 22 isolates (51.2%) shared eight genotypes, suggesting clonal strains. Strains from each of seven genotypes (total, 19 isolates) were isolated among the 22 clonal strains within a 6-month period, whereas three strains of one genotype were obtained over a 3-year interval. Our findings suggest that horizontal transmission of C. albicans may occur more frequently than vertical transmission among NICU patients and that MLST appears to be a useful method for genotyping C. albicans strains isolated from NICU patients.

Published
2014
Full Text
View/download PDF

4. Adaptive Differentiation ofPlasmodium falciparumPopulations Inferred from Single‐Nucleotide Polymorphisms (SNPs) Conferring Drug Resistance and from Neutral SNPs

Author

Rabia Mazmouz, Agnès Aubouy, Emmanuelle Renard, Sabah A. Omar, Jérôme Clain, Sarah Falcão, Emeline Broussier, Abdoulaye Djimde, Vély Jean-François, Jean-François Lepère, Jacques Le Bras, Dorina G. Bustos, Oumou Maïga-Ascofaré, Milijaona Randrianarivelojosia, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD) - Université Paris Descartes - Paris 5 (UPD5), Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odontostomatology, Université de Bamako, Centre de consultations de Bandraboua, Research Institute for Tropical Medicine, Institut Pasteur de Madagascar, Institut Pasteur de Madagascar - Réseau International des Instituts Pasteur (RIIP), Kenya Medical Research Institute, Unité de Recherche 010, IRD, Service National de Lutte Antipaludique, Financial support: French Ministry of Health (grant to the Centre National de Réference du Paludisme), Institut de Médecine et d'Epidémiologie Appliquée/Fondation Léon Mba (grant 5988CLN90PFGO), French Ministry of Foreign Affairs for the France-Philippine Technical Cooperation Project on Malaria (grant), Bio-MalPar Network of Excellence., Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Réseau International des Instituts Pasteur (RIIP), and Kenya Medical Research Institute (KEMRI)

Subjects
Male, MESH: Philippines, MESH: Geography, Philippines, [SDV]Life Sciences [q-bio], Genes, Protozoan, Adaptation, Biological, Drug Resistance, MESH : Aged, Drug resistance, MESH: Africa, MESH : Child, Preschool, MESH : Malaria, Falciparum, MESH: Aged, 80 and over, 0302 clinical medicine, MESH : Child, Polymorphism (computer science), MESH: Child, MESH : Haiti, MESH : Philippines, MESH : Plasmodium falciparum, Immunology and Allergy, MESH : Female, MESH : Adaptation, Biological, Malaria, Falciparum, Child, MESH : DNA, Protozoan, MESH: Plasmodium falciparum, Aged, 80 and over, MESH: Aged, Genetics, 0303 health sciences, MESH: Middle Aged, Geography, biology, MESH: Polymorphism, Single Nucleotide, MESH: Malaria, Falciparum, MESH: Infant, Newborn, MESH : Polymorphism, Single Nucleotide, MESH : Geography, MESH : Infant, Middle Aged, MESH : Adult, MESH: Infant, 3. Good health, [SDV] Life Sciences [q-bio], MESH: Haiti, Infectious Diseases, MESH: Genes, Protozoan, MESH: Young Adult, Child, Preschool, MESH : Genes, Protozoan, MESH: Drug Resistance, Female, Adult, Adolescent, MESH : Africa, MESH : Male, Plasmodium falciparum, 030231 tropical medicine, MESH : Young Adult, MESH: DNA, Protozoan, Context (language use), Single-nucleotide polymorphism, MESH : Infant, Newborn, Polymorphism, Single Nucleotide, Young Adult, 03 medical and health sciences, MESH : Adolescent, parasitic diseases, Humans, MESH : Middle Aged, Allele, MESH : Aged, 80 and over, Gene, Allele frequency, Aged, 030304 developmental biology, MESH: Adolescent, MESH : Drug Resistance, MESH: Humans, MESH: Adaptation, Biological, MESH: Child, Preschool, MESH : Humans, Infant, Newborn, Infant, MESH: Adult, DNA, Protozoan, biology.organism_classification, Haiti, MESH: Male, Africa, MESH: Female
Abstract

International audience; BACKGROUND: Theoretical and experimental data support the geographic differentiation strategy as a valuable tool for detecting loci under selection. In the context of Plasmodium falciparum malaria, few populations have been studied, with limited genomic coverage. METHODS: We examined geographic differentiation in P. falciparum populations on the basis of 12 single-nucleotide polymorphisms (SNPs) in 4 genes encoding drug resistance determinants, 5 SNPs in 2 genes encoding antigens, and a set of 17 putatively neutral SNPs dispersed on 13 chromosomes. We sampled 326 parasite isolates representing 7 P. falciparum populations from regions with varied levels of malaria transmission (Gabon, Kenya, Madagascar, Mali, Mayotte, Haiti, and the Philippines). RESULTS: Frequencies of drug resistance alleles varied considerably among populations (mean F(ST), 0.52). In contrast, allele frequencies varied significantly less for antigenic and neutral SNPs (mean F(ST), 0.16 and 0.24, respectively). This contrasting pattern was more pronounced when only the African populations were considered. Signature of selection was detected for most of the resistant SNPs but not for the antigenic SNPs. CONCLUSION: These data further validate the utility of geographic differentiation for identifying loci under strong positive selection, such as drug resistance loci. This study also provides frequencies of molecular makers of resistance in some overlooked populations.

Published
2010
Full Text
View/download PDF

5. Re: 'Socioeconomic Differences in Cardiometabolic Factors: Social Casusation or Health-Related Selection? Evidence from the Whitehall II Cohort Study, 1991-2004'

Author

Marianna Virtanen, Marko Elovainio, Eric J. Brunner, Jenny Head, G. David Batty, Martin J. Shipley, Mark Hamer, Michael Marmot, Archana Singh-Manoux, Mika Kivimäki, Jane E. Ferrie, Markus Jokela, Behavioural Sciences, Department of Epidemiology and Public Health, University College of London [London] (UCL), National Research and Development Centre for Welfare and Health, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Behavioral Sciences, Finnish Institute of Occupational Health, The Whitehall II study has been supported by grants from the Medical Research Council, British Heart Foundation, Health and Safety Executive, Department of Health, National Heart Lung and Blood Institute (HL36310), US, NIH: National Institute on Aging (AG13196, R01 AG034454), US, NIH, Agency for Health Care Policy Research (HS06516), and the John D and Catherine T MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health. ME is supported by Work Environment Fund and the Academy of Finland (Grant number 128002). MK is supported by the BUPA Foundation, the Academy of Finland and the EU New OSH ERA Research Programme Grant, GDB is a Wellcome Trust Research Fellow, AS-M is supported by a 'EURYI' award from the European Science Foundation, JEF is supported by the Medical Research Council, MJS and MH are supported by the British Heart Foundation, and and MGM is supported by a MRC Research Professorship.

Subjects
Male, Gerontology, REPORTED BIRTH-WEIGHT, MESH: Lipoproteins, LDL, Epidemiology, Original Contributions, MESH: Logistic Models, 030204 cardiovascular system & hematology, CIVIL-SERVANTS, Cohort Studies, 0302 clinical medicine, Risk Factors, MESH: Metabolic Syndrome X, MESH: Risk Factors, MESH: Child, longitudinal studies, Medicine, 030212 general & internal medicine, Child, MESH: Cohort Studies, Metabolic Syndrome, MESH: Aged, 2. Zero hunger, MESH: Middle Aged, MESH: Employment, MESH: Infant, Newborn, public health, CHILDHOOD HEALTH, Middle Aged, 3142 Public health care science, environmental and occupational health, 3. Good health, Causality, Lipoproteins, LDL, MESH: Health Status Disparities, MESH: Great Britain, Female, medicine.symptom, Cohort study, Adult, Employment, MESH: Socioeconomic Factors, medicine.medical_specialty, Waist, Birth weight, MESH: Infant, Low Birth Weight, MESH: Causality, MESH: Social Class, 03 medical and health sciences, Humans, Whitehall Study, CORONARY-HEART-DISEASE, VALIDITY, Socioeconomic status, Selection (genetic algorithm), Socioeconomic differences, Aged, MESH: Humans, business.industry, Public health, INCOME INEQUALITY, MORTALITY, Infant, Newborn, MESH: Cardiovascular Diseases, Health related, MESH: Adult, Infant, Low Birth Weight, medicine.disease, United Kingdom, MESH: Male, health status disparities, cardiovascular diseases, Low birth weight, Logistic Models, Socioeconomic Factors, MOBILITY, RISK-FACTORS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, metabolic syndrome X, Metabolic syndrome, social class, AFFECTIVE-DISORDER, business, MESH: Female, Body mass index, Demography
Abstract

International audience; In this study, the health-related selection hypothesis (that health predicts social mobility) and the social causation hypothesis (that socioeconomic status influences health) were tested in relation to cardiometabolic factors. The authors screened 8,312 United Kingdom men and women 3 times over 10 years between 1991 and 2004 for waist circumference, body mass index, systolic and diastolic blood pressure, fasting glucose, fasting insulin, serum lipids, C-reactive protein, and interleukin-6; identified participants with the metabolic syndrome; and measured childhood health retrospectively. Health-related selection was examined in 2 ways: 1) childhood health problems as predictors of adult occupational position and 2) adult cardiometabolic factors as predictors of subsequent promotion at work. Social causation was assessed using adult occupational position as a predictor of subsequent change in cardiometabolic factors. Hospitalization during childhood and lower birth weight were associated with lower occupational position (both P's ≤ 0.002). Cardiometabolic factors in adulthood did not consistently predict promotion. In contrast, lower adult occupational position predicted adverse changes in several cardiometabolic factors (waist circumference, body mass index, fasting glucose, and fasting insulin) and an increased risk of new-onset metabolic syndrome (all P's ≤ 0.008). These findings suggest that health-related selection operates at younger ages and that social causation contributes to socioeconomic differences in cardiometabolic health in midlife.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results