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Start Over Author "McGuire, Philip" Publisher oxford university press (oup)
121 results on '"McGuire, Philip"'

2. Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial

Author

Susai, Subash Raj, primary, Föcking, Melanie, additional, Mongan, David, additional, Heurich, Meike, additional, Coutts, Fiona, additional, Egerton, Alice, additional, Whetton, Tony, additional, Winter-van Rossum, Inge, additional, Unwin, Richard D, additional, Pollak, Thomas A, additional, Weiser, Mark, additional, Leboyer, Marion, additional, Rujescu, Dan, additional, Byrne, Jonah F, additional, Gifford, George W, additional, Dazzan, Paola, additional, Koutsouleris, Nikolaos, additional, Kahn, René S, additional, Cotter, David R, additional, and McGuire, Philip, additional

Published
2023
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3. Semantic Speech Networks Linked to Formal Thought Disorder in Early Psychosis

Author

Nettekoven, Caroline R, primary, Diederen, Kelly, additional, Giles, Oscar, additional, Duncan, Helen, additional, Stenson, Iain, additional, Olah, Julianna, additional, Gibbs-Dean, Toni, additional, Collier, Nigel, additional, Vértes, Petra E, additional, Spencer, Tom J, additional, Morgan, Sarah E, additional, and McGuire, Philip, additional

Published
2023
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4. Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk

Author

Davies, Cathy, primary, Bossong, Matthijs G, additional, Martins, Daniel, additional, Wilson, Robin, additional, Appiah-Kusi, Elizabeth, additional, Blest-Hopley, Grace, additional, Allen, Paul, additional, Zelaya, Fernando, additional, Lythgoe, David J, additional, Brammer, Michael, additional, Perez, Jesus, additional, McGuire, Philip, additional, and Bhattacharyya, Sagnik, additional

Published
2023
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5. Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia

Author

Lei, Du, primary, Qin, Kun, additional, Pinaya, Walter H L, additional, Young, Jonathan, additional, Van Amelsvoort, Therese, additional, Marcelis, Machteld, additional, Donohoe, Gary, additional, Mothersill, David O, additional, Corvin, Aiden, additional, Vieira, Sandra, additional, Lui, Su, additional, Scarpazza, Cristina, additional, Arango, Celso, additional, Bullmore, Ed, additional, Gong, Qiyong, additional, McGuire, Philip, additional, and Mechelli, Andrea, additional

Published
2022
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7. Changes in Brain Glutamate on Switching to Clozapine in Treatment-Resistant Schizophrenia

Author

McQueen, Grant, primary, Sendt, Kyra-Verena, additional, Gillespie, Amy, additional, Avila, Alessia, additional, Lally, John, additional, Vallianatou, Kalliopi, additional, Chang, Nynn, additional, Ferreira, Diogo, additional, Borgan, Faith, additional, Howes, Oliver D, additional, Barker, Gareth J, additional, Lythgoe, David J, additional, Stone, James M, additional, McGuire, Philip, additional, MacCabe, James H, additional, and Egerton, Alice, additional

Published
2021
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8. Neural circuitry of novelty salience processing in psychosis risk: association with clinical outcome

Author

McGuire, Philip, Grace, Anthony A., Stone, James M., Howes, Oliver D., Perez, Jesus, Broome, Matthew R., Bossong, Matthijs G., Antoniades, Mathilde, Smart, Sophie E., Gifford, George W. G., Quinn, Beverly, Bonoldi, Ilaria, Samson, Carly, Azis, Matilda, Dima, Danai, Zugman, Andre, Allen, Paul, and Modinos, Gemma

Subjects
nervous system
Abstract

Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high-risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 years), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic disorder (CHR-T) and 63 did not. Functional activation and effective connectivity within a hippocampal-striatal-midbrain circuit were compared between groups. In CHR individuals compared to HC, hippocampal response to novel stimuli was significantly attenuated (P=0.041 family-wise error corrected). Dynamic Causal Modelling revealed that stimulus novelty modulated effective connectivity from the hippocampus to the striatum, and from the midbrain to the hippocampus, significantly more in CHR participants than in HC. Conversely, stimulus novelty modulated connectivity from the midbrain to the striatum significantly less in CHR participants than in HC, and less in CHR participants who subsequently developed psychosis than in CHR individuals who did not become psychotic. Our findings are consistent with preclinical evidence implicating hippocampal-striatal-midbrain circuit dysfunction in altered salience processing and the onset of psychosis.

Published
2020

9. Cannabis Use Linked to Altered Functional Connectivity of the Visual Attentional Connectivity in Patients With Psychosis and Controls

Author

Sami, Musa Basseer, McCutcheon, Robert A., Ettinger, Ulrich, Williams, Steve, Lythgoe, Dave, McGuire, Philip, and Bhattacharyya, Sagnik

Abstract

Background: Both chronic cannabis use and psychotic disorders are associated with abnormalities in visual atten-tional processing. Using functional magnetic resonance imaging (fMRI), we sought to determine whether there would be a difference in functional connectivity in patients and controls with and without a history of cannabis use in the visual and dorsal attention networks. Methods: Resting-state fMRI data were acquired in patients with early psy-chosis with (EPC = 29) and without (EPNC = 25); and controls with (HCC = 16) and without (HCNC = 22) cannabis use. Results: There was a patient effect in both Visual-Dorsal Attention Internetwork (F(1,87) = 5.326, P = .023) and the Visual Network (F(1,87) = 4.044, P = .047) and a cannabis effect in the Dorsal Attention Network (F(1,87) = 4.773, P = .032). These effects were specific to the networks examined with no evidence for significant patient or cannabis effects in other canonical networks. Patients with a history of cannabis use showed increased connec-tivity in the Dorsal Attention Network (134%, P = .019) and Visual Dorsal Attention Internetwork (285%, P = .036) compared to non-using controls. In the EPC group con-nectivity of the Visual Network (? = 0.379, P = .042) and Visual-Dorsal Attention Internetwork (? = 0.421, P = .023) correlated with visual hallucinations which were significantly different from EPNC (P = .011). Dorsal attention network strength correlated with severity of dependence for cannabis (? = 0.215, P = .04). Conclusion: We demonstrate specific cannabis and patient effects in networks associated with visual attentional processing. There is a differential association with hallucinatory symptoms in patients with and without a history of cannabis use. This may indicate that dysconnectivity in these networks serves different roles in the context of cannabis use.

Published
2020

10. Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA)

Author

Egerton, Alice, primary, Murphy, Anna, additional, Donocik, Jacek, additional, Anton, Adriana, additional, Barker, Gareth J, additional, Collier, Tracy, additional, Deakin, Bill, additional, Drake, Richard, additional, Eliasson, Emma, additional, Emsley, Richard, additional, Gregory, Catherine J, additional, Griffiths, Kira, additional, Kapur, Shitij, additional, Kassoumeri, Laura, additional, Knight, Laura, additional, Lambe, Emily J B, additional, Lawrie, Stephen M, additional, Lees, Jane, additional, Lewis, Shôn, additional, Lythgoe, David J, additional, Matthews, Julian, additional, McGuire, Philip, additional, McNamee, Lily, additional, Semple, Scott, additional, Shaw, Alexander D, additional, Singh, Krish D, additional, Stockton-Powdrell, Charlotte, additional, Talbot, Peter S, additional, Veronese, Mattia, additional, Wagner, Ernest, additional, Walters, James T R, additional, Williams, Stephen R, additional, MacCabe, James H, additional, and Howes, Oliver D, additional

Published
2020
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16. T21. DEVELOPMENT OF PROTEOMIC PREDICTION MODELS FOR OUTCOMES IN THE CLINICAL HIGH RISK STATE AND PSYCHOTIC EXPERIENCES IN ADOLESCENCE: MACHINE LEARNING ANALYSES IN TWO NESTED CASE-CONTROL STUDIES

Author

Mongan, David, primary, Föcking, Melanie, primary, Healy, Colm, primary, Raj Susai, Subash, primary, Cagney, Gerard, primary, Cannon, Mary, primary, Zammit, Stanley, primary, Nelson, Barnaby, primary, McGorry, Patrick, primary, Nordentoft, Merete, primary, Krebs, Marie-Odile, primary, Riecher-Rössler, Anita, primary, Bressan, Rodrigo, primary, Barrantes-Vidal, Neus, primary, Borgwardt, Stefan, primary, Ruhrmann, Stephan, primary, Sachs, Gabriele, primary, Van der Gaag, Mark, primary, Rutten, Bart, primary, Pantelis, Christos, primary, De Haan, Lieuwe, primary, Valmaggia, Lucia, primary, Kempton, Matthew, primary, McGuire, Philip, primary, and Cotter, David, primary

Published
2020
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19. T139. OXYTOCIN ENHANCES NEURAL EFFICIENCY IN INFERRING OTHERS’ SOCIAL EMOTIONS IN PEOPLE AT CLINICAL HIGH RISK FOR PSYCHOSIS

Author

Schmidt, André, primary, Davies, Cathy, primary, Paloyelis, Yannis, primary, Rutigliano, Grazia, primary, Cappucciati, Marco, primary, De Micheli, Andrea, primary, Ramella-Cravaro, Valentina, primary, Provenzani, Umberto, primary, Scutt, Eleanor, primary, Oliver, Dominic, primary, Murguia, Silvia, primary, Zelaya, Fernando, primary, Allen, Paul, primary, Shergill, Sukhi, primary, Morrison, Paul, primary, Williams, Steven, primary, Taylor, David, primary, Lythgoe, David J, primary, Borgwardt, Stefan, primary, McGuire, Philip, primary, and Fusar-poli, Paolo, primary

Published
2020
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20. M163. GLUTAMATE METABOLITES ARE ASSOCIATED WITH ALTERED HIPPOCAMPAL ACTIVATION BUT NOT HIPPOCAMPAL-STRIATAL CONNECTIVITY IN SUBJECTS WITH A CLINICAL HIGH RISK FOR PSYCHOSIS

Author

Hird, Emily, primary, Allen, Paul, primary, Orlov, Natasza, primary, Modinos, Gemma, primary, Bossong, Matthijs, primary, Antoniades, Mathilde, primary, Sampson, Carly, primary, Azis, Matilda, primary, Howes, Oliver, primary, Stone, James, primary, Grace, Antony, primary, and McGuire, Philip, primary

Published
2020
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28. Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study

Author

Kraan, Tamar C., Velthorst, Eva, Themmen, Manouk, Valmaggia, Lucia, Kempton, Matthew J., McGuire, Phillip, Van Os, Jim, Rutten, Bart P.F., Smit, Filip, De Haan, Lieuwe, Van Der Gaag, Mark, McGuire, Philip, Valmaggia, Lucia R., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Burger, Nadine, Van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Naumann, Tanya Louise, Glenthøj, Louise Birkedal, Nordentoft, Merete, De Hert, Marc, Van Winkel, Ruud, Nelson, Barnaby, McGorry, Patrick, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and Epidemiology and Data Science

Subjects
Male, Child abuse, INCREASES, clinical outcome, Poison control, Stress Disorders, Post-Traumatic, 0302 clinical medicine, Risk Factors, SCHIZOPHRENIA, Child Abuse, psychosis, Psychological abuse, ultra high risk, Adult Survivors of Child Abuse, PSYCHOPATHOLOGY, Justice and Strong Institutions, Europe, Psychiatry and Mental health, Schizophrenia, Panic Disorder, Female, Psychology, TRANSITION, Psychopathology, Clinical psychology, Adult, medicine.medical_specialty, Psychosis, SDG 16 - Peace, LIFE EVENTS, Adolescent, DISORDERS, Young Adult, 03 medical and health sciences, medicine, Humans, COHORT, Risk factor, Psychiatry, METAANALYSIS, Depressive Disorder, Panic disorder, SDG 16 - Peace, Justice and Strong Institutions, Phobia, Social, medicine.disease, 030227 psychiatry, CONVERSION, Psychotic Disorders, child maltreatment, TRAUMATIC EXPERIENCES, 030217 neurology & neurosurgery, Regular Articles, Follow-Up Studies
Abstract

Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.

Published
2017

29. Antibodies in the diagnosis, prognosis, and prediction of psychotic disorders

Author

Pollak, Thomas A, Rogers, Jonathan P, Nagele, Robert G, Peakman, Mark, Stone, James M, David, Anthony S, and McGuire, Philip

Abstract

Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a top-down approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging bottom-up or omics approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the antibody repertoire. Here we review the evidence for antibodies (to self-antigens as well as infectious organism and dietary antigens) as biomarkers of diagnosis, prognosis, and treatment response in psychotic disorders. Neuronal autoantibodies have current, and increasing, clinical utility in the diagnosis of organic or atypical psychosis syndromes. Antibodies to selected infectious agents show some promise in predicting cognitive impairment and possibly other symptom domains (eg, suicidality) within psychotic disorders. Finally, infectious antibodies and neuronal and other autoantibodies have recently emerged as potential biomarkers of response to anti-infective therapies, immunotherapies, or other novel therapeutic strategies in psychotic disorders, and have a clear role in stratifying patients for future clinical trials. As in nonpsychiatric disorders, combining biomarkers and large-scale use of bottom-up approaches to biomarker identification are likely to maximize the eventual clinical utility of antibody biomarkers in psychotic disorders.

Published
2019

30. Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome

Author

Modinos, Gemma, primary, Allen, Paul, primary, Zugman, Andre, primary, Dima, Danai, primary, Azis, Matilda, primary, Samson, Carly, primary, Bonoldi, Ilaria, primary, Quinn, Beverly, primary, Gifford, George W G, primary, Smart, Sophie E, primary, Antoniades, Mathilde, primary, Bossong, Matthijs G, primary, Broome, Matthew R, primary, Perez, Jesus, primary, Howes, Oliver D, primary, Stone, James M, primary, Grace, Anthony A, primary, and McGuire, Philip, primary

Published
2019
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33. O5.6. REMISSION FROM ANTIPSYCHOTIC TREATMENT IN FIRST EPISODE PSYCHOSIS RELATED TO LONGITUDINAL CHANGES IN BRAIN GLUTAMATE LEVELS

Author

Merritt, Kate, primary, Perez-Iglesias, Rocio, additional, Sendt, Kyra-Verena, additional, Goozee, Rhianna, additional, Jauhar, Sameer, additional, Pepper, Fiona, additional, Barker, Gareth J, additional, Glenthoj, Birte, additional, Arango, Celso, additional, Lewis, Shon, additional, Kahn, René, additional, Stone, James, additional, Howes, Oliver, additional, Dazzan, Paola, additional, McGuire, Philip, additional, and Egerton, Alice, additional

Published
2019
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34. O7.3. ALTERED HIPPOCAMPAL-STRIATAL-MIDBRAIN FUNCTION IN SUBJECTS AT CLINICAL HIGH RISK OF PSYCHOSIS

Author

Modinos, Gemma, primary, Allen, Paul, additional, Zugman, Andre, additional, Dima, Danai, additional, Azis, Matilda, additional, Samson, Carly, additional, Bonoldi, Ilaria, additional, Quinn, Beverly, additional, Gifford, George, additional, Smart, Sophie, additional, Antoniades, Mathilde, additional, Bossong, Matthijs, additional, Broome, Matthew R, additional, Perez, Jesus, additional, Howes, Oliver D, additional, Stone, James M, additional, Grace, Anthony A, additional, and McGuire, Philip, additional

Published
2019
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35. O13.5. GLUTAMATERGIC METABOLITES ASSOCIATED WITH ALTERED HIPPOCAMPAL AND STRIATAL ACTIVATION DURING NOVELTY SALIENCE IN PEOPLE WITH A CLINICAL HIGH RISK FOR PSYCHOSIS

Author

Allen, Paul, primary, Modinos, Gemma, additional, Bossong, Matthijs, additional, Antoniades, Mathilde, additional, Samson, Carly, additional, Azis, Matilda, additional, Howes, Oliver, additional, Stone, James, additional, Grace, Anthony, additional, and McGuire, Philip, additional

Published
2019
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36. O3.7. SMOOTH PURSUIT EYE MOVEMENTS INDICATE BIOLOGICAL DISTINCTION BETWEEN CANNABIS-USING AND NON-USING PATIENTS IN EARLY PSYCHOSIS

Author

Sami, Musa, primary, Annibale, Luciano, additional, O’Neill, Aisling, additional, Collier, Tracey, additional, Onyejiaka, Chidimma, additional, Eranti, Savitha, additional, Das, Debasis, additional, Kelbrick, Marlene, additional, McGuire, Philip, additional, Williams, Steve, additional, Ettinger, Ulrich, additional, and Bhattacharyya, Sagnik, additional

Published
2019
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38. O6.5. INVESTIGATING VARIABLES FROM THE NAPLS RISK CALCULATOR FOR PSYCHOSIS IN THE EU-GEI HIGH RISK STUDY

Author

Kempton, Matthew, primary, Valmaggia, Lucia, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Fusar-poli, Paolo, additional, Antoniades, Mathilde, additional, Van der Gaag, Mark, additional, Haan, Lieuwe De, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart, additional, Os, Jim Van, additional, McGuire, Philip, additional, WP, EU-GEI, additional, and Study, High Risk, additional

Published
2019
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39. 17.4 STRATIFICATION AND PREDICTION OF REMISSION IN FIRST-EPISODE PSYCHOSIS PATIENTS: THE OPTiMISE COHORT STUDY

Author

Glaichenhaus, Nicolas, primary, Barbosa, Susana, additional, Martinuzzi, Emanuella, additional, Gilet, Cyprien, additional, Jamain, Stéphane, additional, Sommer, Iris, additional, Leucht, Stefan, additional, Dazzan, Paola, additional, McGuire, Philip, additional, Arango, Celso, additional, Diaz-Caneja, Covadonga M, additional, Fleischhacker, Wolfgang, additional, Rujescu, Dan, additional, Glenthoj, Birte, additional, Kahn, Rene, additional, Yolken, Robert, additional, Lewis, Shon, additional, Drake, Richard, additional, Laetitia, Davidovic, additional, and Leboyer, Marion, additional

Published
2019
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44. Using Machine Learning and Structural Neuroimaging to Detect First Episode Psychosis: Reconsidering the Evidence

Author

Vieira, Sandra, primary, Gong, Qi-yong, additional, Pinaya, Walter H L, additional, Scarpazza, Cristina, additional, Tognin, Stefania, additional, Crespo-Facorro, Benedicto, additional, Tordesillas-Gutierrez, Diana, additional, Ortiz-García, Victor, additional, Setien-Suero, Esther, additional, Scheepers, Floortje E, additional, Van Haren, Neeltje E M, additional, Marques, Tiago R, additional, Murray, Robin M, additional, David, Anthony, additional, Dazzan, Paola, additional, McGuire, Philip, additional, and Mechelli, Andrea, additional

Published
2019
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45. Liberal Acceptance Bias, Momentary Aberrant Salience, and Psychosis: An Experimental Experience Sampling Study

Author

Reininghaus, Ulrich, primary, Oorschot, Margaret, additional, Moritz, Steffen, additional, Gayer-Anderson, Charlotte, additional, Kempton, Matthew J, additional, Valmaggia, Lucia, additional, McGuire, Philip, additional, Murray, Robin, additional, Garety, Philippa, additional, Wykes, Til, additional, Morgan, Craig, additional, and Myin-Germeys, Inez, additional

Published
2018
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