1. Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate
- Author
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Cameron T. Whitley, Richard Cathomas, Claire M. Connell, Peter Wilson, Tobias Janowitz, Tamer Al-Sayed, Harry Potts, Helena M. Earl, Michael J. Dooley, Ian Beh, James M.J. Weaver, Gianfilippo Bertelli, Duncan I. Jodrell, Simon Tavaré, Martin Fehr, Edward H. Williams, Andy G. Lynch, Phillip J. Monaghan, Michael A. Bookman, Nicholas J. Bird, Amy Quinton, Paul D. Lewis, Susan Poole, Jonathan Shamash, Patrick B. Mark, Williams, Edward H [0000-0001-9187-2258], Connell, Claire M [0000-0002-6696-8415], Potts, Harry [0000-0002-3098-0527], Monaghan, Phillip J [0000-0003-1778-3892], Bertelli, Gianfilippo [0000-0002-1798-0098], Poole, Susan [0000-0003-4582-9472], Mark, Patrick B [0000-0003-3387-2123], Bookman, Michael A [0000-0002-4255-7814], Earl, Helena [0000-0003-1549-8094], Jodrell, Duncan [0000-0001-9360-1670], Tavaré, Simon [0000-0002-3716-4952], Lynch, Andy G [0000-0002-7876-7338], Janowitz, Tobias [0000-0002-7820-3727], Apollo - University of Cambridge Repository, University of St Andrews. Statistics, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, and University of St Andrews. School of Medicine
- Subjects
Cancer Research ,medicine.medical_specialty ,Kidney Disease ,Renal and urogenital ,Urology ,Renal function ,32 Biomedical and Clinical Sciences ,Isotope dilution ,Brief Communication ,RC0254 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Clinical Research ,medicine ,In patient ,3202 Clinical Sciences ,Cancer ,030304 developmental biology ,0303 health sciences ,Kidney ,Creatinine ,RC0254 Neoplasms. Tumors. Oncology (including Cancer) ,business.industry ,3rd-DAS ,medicine.disease ,3. Good health ,medicine.anatomical_structure ,Oncology ,chemistry ,Creatinine Measurement ,030220 oncology & carcinogenesis ,business ,Kidney disease - Abstract
This work was supported by Cancer Research UK (EHW, TJ: C42738/A24868); National Institute of Health Research Cambridge Biomedical Research Centre (HE); National Institute of Health Research UK Academic Clinical Fellowship (CMC); and National Institutes of Health USA Cancer Center support grant (TJ: 5P30CA045508-31). Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicentre comparison of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry (non-IDMS), we studied 3,620 patients with cancer and 166 without cancer who had their GFR measured with an exogenous nuclear tracer at one of seven clinical centres. The mean measured GFR was 86 ml/min. Accuracy of all models was centre-dependent, reflecting inter-centre variability of non-IDMS creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared-error (RMSE) 17.3 ml/min) followed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) model (RMSE 18.2 ml/min).Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicentre comparison of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry (non-IDMS), we studied 3,620 patients with cancer and 166 without cancer who had their GFR measured with an exogenous nuclear tracer at one of seven clinical centres. The mean measured GFR was 86 ml/min. Accuracy of all models was centre-dependent, reflecting inter-centre variability of non-IDMS creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared-error (RMSE) 17.3 ml/min) followed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) model (RMSE 18.2 ml/min).Important oncological management decisions rely on kidney function assessed by serum creatinine–based estimated glomerular filtration rate (eGFR). However, no large-scale multicenter comparisons of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry, we studied 3620 patients with cancer and 166 without cancer who had their glomerular filtration rate (GFR) measured with an exogenous nuclear tracer at one of seven clinical centers. The mean measured GFR was 86 mL/min. Accuracy of all models was center dependent, reflecting intercenter variability of isotope dilution mass spectrometry–creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared error 17.3 mL/min) followed by the Chronic Kidney Disease Epidemiology Collaboration model (root-mean-squared error 18.2 mL/min). Publisher PDF
- Published
- 2019