1. Does size matter? Kidney transplant donor size determines kidney function among living donors
- Author
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Meenakshi Narasimhamurthy, Jason T. Machan, Lachlan M. Smith, Steven E. Reinert, Nikunjkumar Patel, Reginald Y. Gohh, Michael D. Beland, Lance D. Dworkin, Susie L. Hu, and Basma Merhi
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,kidney transplantation ,Renal function ,030230 surgery ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,nephrectomy ,medicine ,Kidney transplantation ,glomerular filtration rate ,Transplantation ,Creatinine ,Kidney ,chronic renal insufficiency ,business.industry ,creatinine ,Kidney transplant donor ,medicine.disease ,Nephrectomy ,medicine.anatomical_structure ,chemistry ,Nephrology ,business ,Donor kidney ,Kidney disease - Abstract
Background Kidney donor outcomes are gaining attention, particularly as donor eligibility criteria continue to expand. Kidney size, a useful predictor of recipient kidney function, also likely correlates with donor outcomes. Although donor evaluation includes donor kidney size measurements, the association between kidney size and outcomes are poorly defined. Methods We examined the relationship between kidney size (body surface area-adjusted total volume, cortical volume and length) and renal outcomes (post-operative recovery and longer-term kidney function) among 85 kidney donors using general linear models and time-to-chronic kidney disease data. Results Donors with the largest adjusted cortical volume were more likely to achieve an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 over a median 24-month follow-up than those with smaller cortical volumes (P
- Published
- 2016
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