1. Are elevated serum haemolysis markers a harbinger of adverse events in HeartMate II patients?
- Author
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Mohammad Amen Khattab, Ann Christina Foldenauer, Usaama Ahmad, Ajay Moza, Andreas Goetzenich, Heike Schnoering, Rüdiger Autschbach, Mohamed Shoaib, Rashad Zayat, L. Tewarie, Christian Stoppe, and Publica
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Gastrointestinal bleeding ,030204 cardiovascular system & hematology ,Hemolysis ,Gastroenterology ,Cohort Studies ,Hemoglobins ,03 medical and health sciences ,0302 clinical medicine ,Von Willebrand factor ,Thromboembolism ,Internal medicine ,von Willebrand Factor ,medicine ,Humans ,030212 general & internal medicine ,Adverse effect ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Heart Failure ,biology ,business.industry ,Incidence ,Hazard ratio ,Thrombosis ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Haemolysis ,Confidence interval ,Stroke ,biology.protein ,Female ,Surgery ,Heart-Assist Devices ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Objectives: Haemolysis during left ventricular assist device support is associated with thrombosis. In this retrospective study, we analysed whether low-level haemolysis (LLH) as defined by simultaneously elevated lactate dehydrogenase (LDH) and free haemoglobin (fHb) levels had an impact on thromboembolic and bleeding events and on von Willebrand factor levels in HeartMate II patients. Methods: After exclusion of patients with LDH >700 U/l and fHb >40 mg/dl at hospital discharge, 79 HeartMate II patients were included. LDH and fHb levels were measured at discharge and in 3 months interval. von Willebrand factor activity and antigen activity were measured 3 months postoperatively. Outcomes regarding ischaemic stroke (IS), pump thrombosis (PT) and gastrointestinal bleeding were recorded. Patients with LLH (400
- Published
- 2018
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