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Background Coronary perforation (CP) is a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI). Although several variables are associated with the risk of coronary perforation, a cumulative risk predictive model has not been established yet. Purpose To assess an incidence, risk factors and to develop risk predictive model for coronary perforation following PCI. Methods A single center, retrospective study of patients who underwent PCI from March 2010 to December 2019. Multivariate regression analysis was performed to identify independent predictors of CP. A risk predictive model was constructed with incremental weights attributed to each component variable according to their beta coefficients. Results 10,671 PCI procedures were enrolled. The incidence of CP was 0.94%. Adverse in-hospital outcomes were significant higher in CP group, including death (odds ratio [OR]: 3.58), mechanical circulatory support; including IABP and ECMO (OR: 3.79) and urgent revascularization (OR: 7.35). Multivariable analysis identified seven independent risk factors for CP, which were age (OR: 1.02), insulin-treated diabetes (OR: 2.50), prior CABG (OR: 2.03), hydrophilic guidewire (OR: 1.62), rotational atherectomy (OR: 2.60), excimer laser coronary atherectomy (ELCA) (OR: 3.39) and chronic total occlusion PCI (OR: 4.21). Risk predictive model (APOLLO-XI score) was calculated from the total points of each variables as follows: age (1 point per 10-year increase), hydrophilic guidewire (2 points), prior CABG (3 points), insulin-treated diabetes or rotational atherectomy (4 points), ELCA (5 points) and chronic total occlusion PCI (6 points). Cumulative risk score more than 11 points had increased risk for coronary perforation more than 1%. The validation of the risk predictive model (C-statistic) was 0.75 (95% CI: 0.70–0.80). Conclusions Coronary perforation is a rare but lethal complication. Our study demonstrates the risk predictive model which could enhance cardiovascular team to precisely estimate risk of coronary perforation before complex PCI procedure. Funding Acknowledgement Type of funding sources: None. Baseline charecteristicsAPOLLO-XI score

Transcatheter aortic valve replacement (TAVR) is a treatment of choice for treating symptomatic severe aortic stenosis patient whose condition is considered the high and intermediate operative risk for surgical aortic valve replacement. Here, we present a case of 67-year-old man with symptomatic severe aortic stenosis, triple vessels disease, type 2 diabetes mellitus and end-stage renal disease who was treated with TAVR. After the valve was deployed, we found the abnormal leakage at descending aorta by transesophageal echocardiogram (TEE). Under intraoperative close monitoring, the dissection was slowly expanding so we decided to perform thoracic endovascular repair (TEVAR). In conclusion, TEE after TAVR procedure is helpful to detect this rare complication. Reported cases of AD status post TAVR Author Sex/Age Comorbidity Detection time of AD Site of AD Detection of AD Treatment for AD Result Route access of TAVR This case 2018 M/67 DM, ESRD Immediate after implant Ds TEE TEVAR Recovery Femoral Losmanova et al. 2018 F/81 NA 3 yrs As Autopsy Conservative Died NR Kratimenos et al. 2016 F/81 COPD, renal dysfunction, angiodysplasia 12 days Ds CT TEVAR Recovery Femoral Nagasawa et al. 2016 F/86 Heart failure During the procedure Ds TEE Conservative Recovery Femoral Yashima et al. 2015(14) F/88 NA 3 days As CT Conservative Recovery Femoral Van Mieghem et al. 2013 F/86 Coronary artery disease, post total knee prosthesis 1-2 hours As Angiogram TEVAR Recovery Femoral Loeser et al. 2013 F/89 NA 2-5 hours As Autopsy NA Cardiogenic shock and died Femoral Bibombe et al. 2013 M/83 Previous CBG, HT, DLP During the procedure As and Ds TEE, CTA, angiogram Open surgery Recovery Femoral Al-Attar et al. 2013 F/84 HT, thrombophlebitis 8 months 2 weeks As CT Open surgery Arrest and died Femoral D"Onofrio et al. 2012 F/79 RA, pulmonary edema, cerebral hemorrhage Immediate after implant As TEE Open surgery Died 32 day later due to septic shock Aortic Ong et al. 2011 M/90 HT, CA prostate, CKD, gastric and duodenal ulcer Immediate after implant As TEE Conservative Recovery Femoral Gerber et al. 2010 F/83 DM, LE 22 days As Autopsy NA Cardiac arrest and died Femoral Abbreviations M Male; F Female; DM Diabetes mellitus; ESRD End-stage renal disease; NA Not available; COPD Chronic obstructive pulmonary disease; CBG Coronary bypass graft; HT hypertension; DLP Dyslipidemia; RA Rheumatoid arthritis; CA cancer; CKD Chronic kidney disease; LE Lupus erythematosus; AD Aortic dissection; As Ascending; Ds Descending; TEVAR Thoracic endovascular aortic repair. Abstract P861 Figure. Intraoperative TEE after TAVR