7 results on '"Norio Hanafusa"'
Search Results
2. Age and anemia management: relationship of hemoglobin levels with mortality might differ between elderly and nonelderly hemodialysis patients
- Author
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Norio Hanafusa, Takeshi Hasegawa, Masaomi Nangaku, and Takanobu Nomura
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aged population ,Male ,medicine.medical_specialty ,Time Factors ,Anemia ,medicine.medical_treatment ,Population ,CLINICAL SCIENCE ,Hemoglobins ,Japan ,Renal Dialysis ,Internal medicine ,Intra- and Extracorporeal Treatments of Kidney Failure ,Humans ,Medicine ,education ,Erythropoietin ,Survival rate ,Dialysis ,Aged ,Proportional Hazards Models ,Transplantation ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Age Factors ,Disease Management ,Middle Aged ,medicine.disease ,mortality ,Surgery ,Survival Rate ,Nephrology ,Cohort ,individualized therapy ,Kidney Failure, Chronic ,Female ,Hemoglobin ,business ,anemia management ,Follow-Up Studies - Abstract
Background. The elderly hemodialyzed population is growing. However, little is known about the relationship between hemoglobin level and survival according to age. We investigated the effect of age on the relationship between hemoglobin and survival within the Japan Dialysis Outcomes and Practice Patterns Study (DOPPS) cohort. Methods. We enrolled the entire Japan DOPPS phases 3 and 4 population. Patients were divided by the age of 75 years into two groups. Cox’s proportional hazard model was used with hemoglobin at every 4 months treated as a time-dependent variable. The interaction of age and hemoglobin was analyzed. Results. We included 3341 patients in the analyses. The primary outcome occurred in 567 patients during the median follow-up of 2.64 years. Hemoglobin of entire population was 10.3 ± 1.3 g/dL. The median of epoetin dose was 3000 IU/ week. Interaction was found between ages stratified by the age of 75 years and hemoglobin values (P = 0.045) with use of Cox’s proportional hazard model. The nonelderly population had poorer prognosis with hemoglobin
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- 2014
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3. SP604HIGHER HEMOGLOBIN LEVEL MAY BE ASSOCIATED WITH USE OF DIPEPTIDYL-PEPTIDASE 4 INHIBITOR IN DIABETIC DIALYSIS PATIENTS
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Atsushi Wada, Norio Hanafusa, Ikuto Masakane, Yoshifumi Ubara, Shigeru Nakai, Takayuki Hamano, Masanori Abe, Junichi Hoshino, and Kenmei Takaichi
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Transplantation ,Nephrology ,business.industry ,Medicine ,Hemoglobin ,Dipeptidyl peptidase-4 inhibitor ,Pharmacology ,business ,Dialysis patients ,medicine.drug - Published
- 2017
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4. Recurrent intestinal bleeding treated by double-balloon endoscopy in haemodialysis patients
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Atsuo Yamada, Eisei Noiri, Osamu Yamazaki, Toshiro Fujita, and Norio Hanafusa
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Gastrointestinal bleeding ,medicine.medical_specialty ,medicine.medical_treatment ,capsule endoscopy ,gastrointestinal bleeding ,Case Report ,End stage renal disease ,law.invention ,Capsule endoscopy ,law ,angiodysplasia ,double-balloon endoscopy ,medicine ,Angiodysplasia ,Transplantation ,end-stage renal disease ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Comorbidity ,Surgery ,Endoscopy ,Nephrology ,Hemodialysis ,business ,Complication - Abstract
Gastrointestinal (GI) bleeding is a common and troublesome complication of end-stage renal disease (ESRD). Patients often have various lesions in the small bowel and in either upper or lower GI tracts. Recently developed double-balloon endoscopy (DBE) enables observation of the entire small intestine through a combination of anterograde and retrograde approaches. Moreover, DBE is useful not only for diagnosis of small intestinal lesions; it provides a mode of treating the disease. This article presents patients with several small intestinal diseases from our facility. Their bleeding sources were identified using DBE. We also report two representative cases of angiodysplasia that had been diagnosed and treated successfully using DBE. One case particularly underscored the usefulness of the combination of capsule endoscopy (CE) and DBE as an electively diagnostic approach for patients with GI bleeding. Small intestinal bleeding is often observable repeatedly in a single patient, as described for case 1. In such circumstances, DBE can treat the lesions successfully without surgical procedures. In this report, ESRD patients, in whom comorbid conditions made it difficult to perform surgical procedures, receive great benefit from DBE.
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- 2009
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5. Sphingosine 1‐phosphate stimulates rat mesangial cell proliferation from outside the cells
- Author
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Masafumi Fukagawa, Toshihiro Okuda, Koei Yamada, Yutaka Yatomi, Norio Hanafusa, Toshiro Fujita, Yuichi Hori, Masaomi Nangaku, and Kiyoshi Kurokawa
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medicine.medical_treatment ,Apoptosis ,chemistry.chemical_compound ,Sphingosine ,medicine ,Animals ,Sphingosine-1-phosphate ,Kinase activity ,Cells, Cultured ,Transplantation ,Mesangial cell ,biology ,Cell growth ,Growth factor ,DNA ,Lipid signaling ,humanities ,Glomerular Mesangium ,Rats ,Cell biology ,chemistry ,Biochemistry ,Nephrology ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Lysophospholipids ,Cell Division ,Platelet-derived growth factor receptor - Abstract
Background. Proliferation of mesangial cells (MCs) is the initial step in glomerulonephritis, and plateletderived mediators have been shown to play a significant role in this proliferation. Sphingosine 1-phosphate (S1P), one of the sphingolipids, is abundantly stored in platelets and is released upon stimulation. We examined the effects of S1P and related sphingolipids on the cell fate of cultured MCs in order to elucidate potential roles of these lipid mediators in glomerulonephritis. Methods. Cell proliferation was evaluated by bromodeoxy uridine (BrdU) incorporation together with MTS assay. Apoptosis of MCs was evaluated by examining annexin V staining and typical morphological changes in nuclei. We also examined the metabolism of w 3 Hxsphingosine in MCs in either the presence or absence of platelet-derived growth factor (PDGF). The expression of endothelial differentiation genes (edg), which are the cell surface receptors for S1P in MCs, was examined by RT-PCR. Results. S1P, but not the other sphingolipids, stimulated MC proliferation. In contrast, dimethylsphingosine (DMS) induced apoptosis in the MCs. The amount of sphingosine (Sph) converted into S1P was small and was not affected by PDGF. This observation suggested that Sph kinase activity producing S1P from Sph was low in the MCs. Furthermore, expression of edg-1 ,- 2 and -5 in MCs was confirmed by RT-PCR. Conclusions. Our observations suggest that S1P stimulates MC proliferation from outside the cells, and not as a second messenger for PDGF. The modulation of MC fate with sphingolipids may provide possible strategies for the treatment of glomerulonephritis.
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- 2002
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6. Contribution of genetically engineered animals to the analyses of complement in the pathogenesis of nephritis
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Masaomi Nangaku, Hajime Sogabe, Takehiko Wada, Toshiro Fujita, Norio Hanafusa, and Koei Yamada
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Mice, Knockout ,Transplantation ,Nephritis ,Mice, Transgenic ,Complement System Proteins ,Complement receptor ,Biology ,Complement system ,Complement (complexity) ,Mice ,Classical complement pathway ,Immune system ,Nephrology ,Immunology ,Knockout mouse ,Animals ,Decay-accelerating factor ,CFHR5 - Abstract
The complement system is indispensable for host defence. Unregulated activation, however, is related to various diseases. In order to elucidate the significance of complement, methodology that disrupts the complement system is essential. Advances in molecular genetics made direct modulations of the genes of complement components and their regulatory proteins feasible. One method is disruption of genes that encode complement components. Several studies have been conducted with these mice in models such as nephrotoxic serum (NTS) nephritis, ischaemia reperfusion and immune complex-mediated glomerulonephritis. These studies all showed that depletion of complement components ameliorated the severity of the diseases. Complement regulatory protein serves a regulatory role in the complement system. Genetically engineered animals that overexpress these proteins have been employed to elucidate their biological roles. Mice overexpressing soluble complement regulatory proteins were protected from the lesion of both NTS and the glomerular endothelial injury model. In contrast, knockout mice that lack expression of decay-accelerating factor (DAF), a complement regulatory protein, developed severe glomerular lesions when subnephritogenic doses of NTS were administered. These genetically engineered animals shed light on the mechanism of initiation and progression of kidney disease.
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- 2002
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7. Epidemiology & outcome in CKD 5D (2)
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M. Fusaro, Tomoyuki Yamakawa, Nynke Halbesma, Ani Shamanadze, Jyoti Baharani, Nino Kankia, Federica Capurro, Maria Tsiatsiou, J. Thumma, Shunichi Fukuhara, Chris Maggs, Enrico Di Stasio, Peir-Haur Hung, S. Amet, Fabian Somers, Sergio Sisca, Caskey Yoav, Norio Hanafusa, Julie Gilg, Doriana Chiarinotti, Valeria Maria Saglimbene, Marco Amidone, C. Combe, Satyanarayana Reddy Vanga, Massimo Liberatori, Ilias Minasidis, M. Plebani, David Ansell, Yoav Ben-Shlomo, Chris A Rogers, Renata Kłak, Gilbert Deray, Marian Klinger, Carlo Navino, G. Crepaldi, Ikuto Masakane, Jorgen Hegbrant, Hiroshi Nishi, Brenda W. Gillespie, S. Maggi, Wei-Chih Kan, J. Zhang, Geison Stein, Francesco Pizzarelli, Giorgia De berardis, Mark Dominik Alscher, Belguzar Kara, Irakli Rtskhiladze, Jaime Madeira, Fergus Caskey, J. Brian Copley, Efstathios Mitsopoulos, João Paulo Martins, R. Cristofaro, Alan Kimber, Eleni Manou, Pasquale Esposito, Antonio Lupo, Jan Bartel, Fabio Pellegrini, Hal Morgenstern, Diana C. Grootendorst, David W. Johnson, Tamar Dzagania, A. D'Angelo, Tone Brit Hortemo Østhus, A. Naso, Paul Clesco, G. Ashuntantang, Rosamund Wilson, Varvara Kousoula, I-Nong Lee, Béla Borbás, Timothy Collier, Andreana De Mauri, Alexandre Hertig, Diogo Bento, Ana Cláudia Miranda, Dorothea Nitsch, Shigeichi Shoji, G. Tripepi, Cheng-Huang Shen, Jean-Yves Gauvrit, Anne Castot, Mariusz Kusztal, Toril Dammen, Joble Joseph, Dimitrios Chanouzas, Silvana Milani, Nicolas Grenier, Raymond T. Krediet, Wacław Kopeć, Sousuke Kagitani, Vittorio Ortalda, Olivier Clément, Pietro Dattolo, Chi-Joung Wang, Saskia le Cessie, Charles R.V. Tomson, Katarzyna Madziarska, Marilena Conte, Kenjiro Yamakawa, Vidojko Djordjevic, Bénédicte Stengel, Pei-Chun Chiang, Carmen Tzanno, Liljana Tozija, Clare Castledine, Krishna Appunu, Lucia Lisi, Stanimir Ljubenovic, Lela Zangurashvili, Eiji Ishimura, Clarissa Uezima, Martino De Leo, Megumi Sato, Shinichi Nishi, L. Calò, Ingrid Os, Maka Lomidze, Carmine Tinelli, Karolina Paunovic, Tewolde Yabarek, Honora Smith, João Cruz, Fernanda Nisihara, Eric Rondeau, Tomasz Gołębiowski, Tamar Khitarishvili, Masaaki Inaba, Nikola Stojcev, Paola Serbelloni, Nino Jashiashvili, Kunitoshi Iseki, Miomir Stojanovic, Ching-Tan Cheng, Magdalena Krajewska, Minoru Ito, Jonathan C. Craig, Józef Penar, Galina Severova Andreevska, Yuzuru Sato, Attilio Di Benedetto, Ewa Zukowska Szczechowska, Zorica Dimitrijevic, Nikoloz Abramishvili, David Metreveli, Senji Okuno, Saso Gelev, J. Harambat, Michele Messa, Pavlina Dzekova, Beatrix Szlanka, Kuan-Yu Hung, Yoshiki Nishizawa, Vili Amitov, S. Giannini, Antonio Dal Canton, Khatuna Buachidze, Marco Righetti, R. Pisoni, Maurice Laville, Chih-Yen Hsiao, Nicolas Janus, Carmen Kreft-Jais, Gianmichele Ferrario, Dinanda J. de Jager, Galina Severova, Bassam Fallouh, D. Miozzo, Satoko Ito, A.P. Kengue, Genevieve Reinhardt, Aleksandar Sikole, Yukinori Johtoku, Vincent Launay-Vacher, Svetlana Pavleska, N. Vajente, Giulia Antognoli, Naveed Aslam, Gjulsen Selim, Junichiro Nagasawa, Katarzyna Gosek, Amin Amro, M. Gallieni, Maka Barnova, Beata Strempska, Shang-Chih Liao, Dimitrios Tsakiris, Camille Francès, Yoshiharu Tsubakihara, Daniele Marcelli, Nicola Panocchia, Goran Paunovic, Mariangela De Maria, Eudoxia Ginikopoulou, Luigi Tazza, Stefano Michelassi, Annalisa De Silvestri, Irma Tschokhonelidze, Khai Ping Ng, Maria Tsikeloudi, Kunihiro Yamagata, Valjbona Preljevic, Olivera Stojceva-Taneva, Michael Smyth, Retha Steenkamp, Friedrich K. Port, Giovanni F.M. Strippoli, Christophe Ridel, Naoki Tsuboniwa, Kyoko Norimine, Chih-Chiang Chien, Adalberto Tommasi, Wacław Weyde, Gabriel Choukroun, Kenichi Kudo, Friedo W. Dekker, Paola David, Lada Trajcevska, Maurizio Bossola, Paul Roderick, Marie Patrice Halle, Peter Rutherford, Hsien-Yi Wang, Lada Trajceska, Elisabeth W. Boeschoten, Paola Tomei, Jyh-Chang Hwang, Nora Sarishvili, Torbjørn Leivestad, and Bruce G. Robinson
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,Epidemiology ,Medicine ,business ,Intensive care medicine ,Outcome (game theory) - Published
- 2011
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