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Erg Chech (EC) 002 is a meteorite with andesitic composition, potentially recording the lava crystallization and crust formation of its parent body. Nucleosynthetic Cr isotope composition (ε54Cr = −0.35 ± 0.06) for EC 002 suggests a non-carbonaceous region of the Solar system, and possibly represents the crustal composition of the brachinite parent body. The 53Mn-to-53Cr decay system shows it crystallized at 4566.6 ± 0.6 Ma, i.e. 0.7 ± 0.6 Ma after Solar system formation (only considering the cogenetic matrix fractions with similar ε54Cr values). This age represents the earliest recorded evidence for planetary melting and volcanism in the Solar system, suggesting that the planetary crust formation occurred very early, only within the first few hundred thousand years of Solar system history. However, the 53Mn–53Cr age does not overlap with 26Al–26Mg dating results, which might indicate that non-carbonaceous achondrites have lower initial 26Al/27Al than the canonical value defined by refractory inclusions in carbonaceous chondrites.

Summary Six cases of eruptive vellus hair cysts (EVHC) were evaluated for histopathology and the immunohistochemical profile of Ki-67 and four keratins (K10, K14, K17 and K19). The pathological hallmark of EVHC was the existence of vellus hair shafts within the cystic cavity, but atypical pathological changes included two or three cysts and a foreign-body granuloma in three cases. Our results demonstrate that atypical pathological changes are not uncommon in EVHC, and indicate that based on keratin expression, it is likely that EVHC is derived from the infrainfundibulum and sebaceous duct.

Mutation is the ultimate source of genetic variation and evolution. Mutation accumulation (MA) experiments are an alternative approach to study de novo mutation events directly. We have constructed a resource of Spontaneous Mutation Accumulation Lines (SMAL; http://cefg.uestc.edu.cn/smal), which contains all the current publicly available MA lines identified by high-throughput sequencing. We have relocated and mapped the mutations based on the most recent genome annotations. A total of 5,608 single base mutations and 540 other mutations were obtained and are recorded in the current version of the SMAL database. The integrated data in SMAL provide detailed information that can be used in new theoretical analyses. We believe that the SMAL resource will help researchers better understand the processes of genetic variation and the incidence of disease.

This goal of this study was to examine immunohistochemical distribution of leukemia inhibitory factor (LIF), LIF receptor (LIFR), and glycoprotein (gp) 130 in rhesus monkey uterus during the menstrual cycle and early pregnancy. Pregnancy rate was significantly reduced in the control group from 66.7% (12 of 18) to 22.2% (4 of 18) with an injection of goat anti-human recombinant LIF immunoglobulin G into the uterine lumen on Day 8 of pregnancy. LIF was mainly localized in glandular and luminal epithelium. LIF immunostaining during the luteal phase was stronger than it was during the proliferative phase. LIF staining gradually increased from Day 3 of pregnancy and reached its highest level on Day 9. LIFR was mainly localized in the glandular and luminal epithelium. LIFR staining during the luteal phase was stronger than it was during the proliferative phase. LIFR staining began to increase from Day 3 of pregnancy and reached a high level on Days 9 and 11. Gp130, a signal-transducing receptor component of LIF, was mainly localized in the glandular epithelium. A high level of gp130 was found on Days 16 and 20 of menstrual cycle, and from Days 5 to 11 of pregnancy. These results suggest that LIF may play an important role in monkey implantation, as it does in mice.

We described a case of a 72-year-old man with frequent premature ventricular contractions (PVC) and recurrent ventricular tachycardia (VT). Multiple anti-arrhythmic medications had failed to relieve symptoms. It was decided to treat the PVC/VT with catheter ablation. Mapping was first …