1. High Proportions of Patients With Advanced HIV Are Antiretroviral Therapy Experienced: Hospitalization Outcomes From 2 Sub-Saharan African Sites
- Author
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Stephen Wanjala, Gilles van Cutsem, Sofie Spiers, Freddy Mangana, Rebecca Harrison, Janet Ousley, David Maman, Alexandra Vandenbulcke, Vincent Lambert, Gisele Lumowo, Tony Kalwangila, Aline Aurore Niyibizi, Beatrice Kirubi, Elisabeth Szumilin, Leon Salumu, Maria Mashako, Ramzia Moudarichirou, Willis Omwoyo, and Janthimala Price
- Subjects
Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,Kenya ,medicine.medical_specialty ,Sub saharan ,Adolescent ,Anti-HIV Agents ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,World health ,Treatment failure ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Antiretroviral Therapy, Highly Active ,Internal medicine ,parasitic diseases ,Humans ,Medicine ,Hospital Mortality ,Prospective Studies ,Treatment Failure ,030212 general & internal medicine ,Advanced HIV Disease ,Africa South of the Sahara ,Retrospective Studies ,business.industry ,Middle Aged ,Democratic Republic of Congo ,030112 virology ,Antiretroviral therapy ,Confidence interval ,CD4 Lymphocyte Count ,Hospitalization ,Treatment Outcome ,Infectious Diseases ,Congo ,Female ,business - Abstract
Background Human immunodeficiency virus (HIV) remains an important cause of hospitalization and death in low- and middle- income countries. Yet morbidity and in-hospital mortality patterns remain poorly characterized, with prior antiretroviral therapy (ART) exposure and treatment failure status largely unknown. Methods We studied HIV-infected inpatients aged ≥13 years from cohorts in Kenya and the Democratic Republic of Congo (DRC), assessing clinical and demographic characteristics and hospitalization outcomes. Kenyan inpatients were prospectively enrolled during hospitalization; identical retrospective data were extracted for Congolese patients meeting the study criteria using routine medical information. Results Among 338 HIV-infected patients in Kenya and 411 in DRC, 83.7% (95% confidence interval [CI], 79.4%–87.3%) and 97.3% (95% CI, 95.2%–98.5%), were admitted with advanced disease (defined as CD4
- Published
- 2018
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