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The late 1980s saw the development of two bodies of literature addressing Japan's relationship to the Asian environmental crisis. The Japanese government's statements were concerned primarily with the contributions Japan could make to solving that crisis, while critical scholars and NGOs focused on ways in which Japanese activity exacerbated it. Using the annual White Papers of the Japan Environment Agency as a guide, this survey article inquires into the extent to which the government has come to engage with the arguments of the critical literature during the 1990s, a decade in which governments and multilateral lending agencies have been forced to deal more closely with environmental concerns. In particular I discuss (1) the extent to which the white papers address Japan's negative impacts on Asia; (2) the ways they treat Japan as a model for Asian environmental policy; and (3) their approach to conflict over policy-making. [ABSTRACT FROM AUTHOR]

Summary: Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to address possible adverse reactions of an autoimmune and inflammatory type that may be caused by adjuvants. While ASIA, as a syndrome, was coined and defined in 2011; reports describing patients with vague and nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came to define, arrange, and unite the variety of symptoms, related to autoimmunity, caused not by the vaccine itself, rather by the adjuvant part of the vaccine such as aluminum, among others. Accordingly, the introduction of ASIA enabled better understanding, proper diagnosis, and early treatment of the disorder. Furthermore, ASIA was shown to be associated with almost all body systems and various rheumatic and autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and systemic sclerosis. In addition, the correlation between COVID-19 and ASIA was noticed during the pandemic. In this review, we summarized the reported effects of adjuvants and medical literature before and after ASIA was defined, the several ways ASIA can manifest and impact different systems of the body, and the incidences of ASIA during the COVID-19 pandemic. It is important to clarify, that vaccines are among, if not the, most effective means of fighting infectious diseases however, we believe that vaccines manufacturing is not above criticism, particularly when it comes to added substances possessing a risk of side effects. Adjuvants such as aluminum, mineral oils, and silicone are added to vaccines in order to trigger a stronger immune response. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was introduced in 2011 to address nonspecific symptoms and disorders appearing following vaccinations, which in fact were reported by many papers before the introduction of the syndrome. During the pandemic of COVID-19, a correlation between ASIA, COVID-19, and COVID-19 vaccines has been reported. [ABSTRACT FROM AUTHOR]

Introduction Disaster epidemiological studies indicate that Asia has the highest frequency of natural disasters. Rural communities are heavily impacted by natural disasters and have different healthcare needs to urban ones. Referencing Asian countries, this paper's objective is to provide an overview of health impacts and the current evidence for designing programmes and policies related to rural health emergency and disaster risk management (health-EDRM). Sources of data This paper uses published English-only reports and papers retrieved from PubMed, Google Scholar, Embase, Medline and PsycINFO on rural disaster and emergency responses and relief, health impact and disease patterns in Asia (January 2000–January 2018). Areas of agreement Earthquakes are the most studied natural disasters in rural communities. The medical burden and health needs of rural communities were most commonly reported among populations of extreme age. Most of the existing research evidence for rural interventions was reported in China. There lacks published peer-reviewed reports of programme impacts on personal and community preparedness. Areas of controversy There is a lack of evidence-based health-EDRM interventions to evaluate implementation effectiveness in rural areas despite vast volumes of health-related disaster literature. Growing points Climate change-related disasters are increasing in frequency and severity. Evidence is needed for disaster risk reduction interventions to address the health risks specific to rural populations. Areas timely for developing research To support global policy development, urgent evidence is needed on the intervention effectiveness, long-term health outcomes, local and cultural relevance as well as sustainability of health relief produced by Health-EDRM programmes in rural areas. [ABSTRACT FROM AUTHOR]

In the closing decade of the 20th century the myriad challenges posed by infectious disease in a globalized environment began to be re-conceptualized as threats to national and human security. The most widely applied model for identifying and responding to such threats is securitization theory, as proposed by the Copenhagen School. Although its analytical framework is generally accepted, its utility remains contested; especially in non-European and non-state settings. The papers in this special edition have several aims: (1) to analyse ways by which Asian states and international organizations have identified health challenges as security threats, (2) to draw upon the securitization model as a way of understanding the full extent to which these states and international organizations have responded to the health threat, and (3) to identify areas where the theory might be strengthened so as to provide greater analytical clarity in areas of health security. This paper acts as a broad introduction to a set of papers on ‘Unhealthy governance’ and explores some of the key findings from the subsequent papers. [ABSTRACT FROM AUTHOR]

The emergence of coronavirus disease-2019 (COVID-19) pandemic has stimulated governments to an extensive discussion on the necessity of COVID-19 vaccination certificate (CVC) to help monitor and manage the rollout of vaccinations and revive the economy. A recent correspondence highlighted the ethical issues concerning COVID-19 diagnostic test results and vaccination certificates. This paper highlights the potential benefits and harms of implementing CVC in the ASEAN region. [ABSTRACT FROM AUTHOR]

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Tapinoma indicum (Forel) (Hymenoptera: Formicidae) is a nuisance pest in Asia countries. However, studies on T. indicum are limited, especially in the field of molecular biology, to investigate the species characteristic at the molecular level. This paper aims to provide valuable genetic markers as tools with which to study the T. indicum population. In this study, a total of 143,998 microsatellite markers were developed based on the 2.61 × 106 microsatellites isolated from T. indicum genomic DNA sequences. Fifty selected microsatellite markers were amplified with varying numbers of alleles ranging from 0 to 19. Seven out of fifty microsatellite markers were characterized for polymorphism with the Hardy–Weinberg equilibrium (HWE) and linkage disequilibrium (LD) analysis. All seven microsatellite markers demonstrated a high polymorphic information content (PIC) value ranging from 0.87 to 0.93, with a mean value of 0.90. There is no evidence of scoring errors caused by stutter peaks, no large allele dropout, and no linkage disequilibrium among the seven loci; although loci Ti-Tr04, Ti-Tr09, Ti-Te04, Ti-Te13, and Ti-Pe5 showed signs of null alleles and deviation from the HWE due to excessive homozygosity. In conclusion, a significant amount of microsatellite markers was developed from the data set of next-generation sequencing, and seven of microsatellite markers were validated as informative genetic markers that can be utilized to study the T. indicum population. [ABSTRACT FROM AUTHOR]

This article focuses on the comparative content analysis of the Arabic press. The purpose of this analysis was to determine the extent to which the reading publics in various Arab countries are being exposed to news of international events. Secondly, the kind of information the press is transmitting and the relative attention it is paying to events involving different countries of Europe, Asia and Africa. Lastly, the favorable or unfavorable images of these other countries that this information is likely to convey to the readers. The content analysis was carried out in two phases. The first concerned the content of the entire newspaper. In this phase, printed space was measured and multiplied by the average number of pages per issue to obtain base totals for each prestige paper. The second phase of the analysis was confined to the first page only. Items appearing on this page were classified in greater detail. In the study it was found that, despite the small size of many Arabic newspapers, papers, internationally significant news, as opposed to news of local or regional reference, absorbs a surprisingly high percentage of total space. Objective changes in the world power situation and in the nature of Arab-Western interaction have not succeeded in suppressing the Arab's preoccupation with external affairs.

The Western Pacific Region is the largest and most diverse region in the world, made up of 37 countries and territories in the Pacific, Oceania and parts of Asia, with a population of more than 1.9 billion people stretching over an area from China and Mongolia in the north to New Zealand in the south. In 1999, 22 countries and territories in the Pacific joined together and launched the Pacific Programme to Eliminate Lymphatic Filariasis. Shortly after, the Global Programme to Eliminate Lymphatic Filariasis was launched in 2000. In 2004, 12 countries in the Asia subregion of the Western Pacific Region and Southeast Asian Region joined and developed the Mekong-Plus Strategic Plan for Elimination of Lymphatic Filariasis. Since then, significant efforts have been made by all endemic countries, with annual mass drug administration (MDA) as a principal strategy, through strong partnership with the WHO and other donors and partners. As a result, by the end of 2019, 10 of 22 endemic countries in the region, including 8 of 16 countries in the Pacific and 2 countries in the Asia subregion, achieved WHO validation for elimination of lymphatic filariasis (LF) as a public health problem. All the other countries are either progressing with post-MDA surveillance or accelerating efforts by adoption of the new triple drug therapy strategy and enhancement of MDA campaigns to tackle persistent transmission. Some 85% of the originally endemic implementation units have stopped MDA and the number of people requiring MDA for LF in the Western Pacific Region was reduced by 72% from 2000 to 2018. This paper reviews the progress, key success factors and remaining challenges and indicates the way forward to achieve LF elimination in the Western Pacific Region. [ABSTRACT FROM AUTHOR]

In this paper, convolutional neural networks (CNNs) were used to distinguish between tectonic and non-tectonic seismicity. The proposed CNNs consisted of seven convolutional layers with small kernels and one fully connected layer, which only relied on the acoustic waveform without extracting features manually. For a single station, the accuracy of the model was 0.90, and the event accuracy could reach 0.93. The proposed model was tested using data from January 2019 to August 2019 in China. The event accuracy could reach 0.92, showing that the proposed model could distinguish between tectonic and non-tectonic seismicity. [ABSTRACT FROM AUTHOR]

The article offers information on a workshop at the 16th World Congress on Public Health 2020 about vaccination challenges in developed and developing countries.

Seismic anisotropy is evidenced in the inner core, upper mantle and the lower crust in large scale, and the evidence is generally provided by shear wave splitting analysis. Here this paper searches for the evidence of anisotropy in the uppermost crust, by using P-wave arrival times from crosshole seismic measurement to directly estimate velocity anisotropy associated with the fine-layering effect of multiple sedimentary beds. Conceptually fine layering causes the so-called VTI (vertical transverse isotropy) anisotropy with a vertical symmetry and the effect is parametrized by the horizontal and vertical velocity ratio. It is found however that the VTI anisotropic parameter does not have a simple vertical symmetry but is also azimuth dependent. This azimuthal anisotropy may reflect the fracture orientation due to large-scale tectonic movements, and is very important in the production of oil reservoirs, as the seismically fast directions can indicate preferred directions of fluid flow. This paper presents innovative methods for anisotropy analysis in both vertical and horizontal plane. Integrated seismic anisotropy interpretation clearly indicates distinguished strain orientations forming fractures in Oligocenic, Miocenic and Pliocenic sediment, in the edge of the extensional basin immediately next to Tan-Lu Fault, an active continental strike-slip fault zone. [ABSTRACT FROM AUTHOR]

This paper discusses why Latin America failed to achieve sustainable convergence with the developed world since 1960 and analyses different phases of convergence and divergence using a structuralist-Keynesian approach. First, it is argued that there are critical differences between Latin America, the developed economies and the Asian economies as regards the evolution of the income elasticity of the demand for imports (π), the rate of growth of exports and the balance-of-payments-constrained rate of growth. The income elasticity of the demand for imports in Latin America showed an upward trend, particularly after the mid-1970s, which was not matched by a similar increase in exports—a pattern in sharp contrast with that of the East Asian countries. The evolution of π and exports are used to set forth a typology of Latin American economic growth since 1960. In addition, the paper relates elasticities and the less favourable Latin American performance to the intensity and direction of structural change. Using a broad sample of developed and developing economies, it is shown that the developing countries that succeed in reducing the income gap are those that transformed their economic structures in favour of sectors with higher Schumpeterian and Keynesian efficiency. [ABSTRACT FROM PUBLISHER]

Research in the field of economic development is increasingly engaged with questions of political economy, of how political choices, institutional structures, and forms of governance influence the economic choices made by governments and citizens. We summarize recent developments in the field and introduce a set of papers that illustrate key themes and methodological innovations associated with the ‘new’ political economy of development. [ABSTRACT FROM PUBLISHER]

This paper reviews recent advances regarding land–atmosphere–ocean coupling associated with the Tibetan Plateau (TP) and its climatic impacts. Thermal forcing over the TP interacts strongly with that over the Iranian Plateau, forming a coupled heating system that elevates the tropopause, generates a monsoonal meridional circulation over South Asia and creates conditions of large-scale ascent favorable for Asian summer monsoon development. TP heating leads to intensification and westward extension (northward movement) of the South Asian High (Atlantic Intertropical Convergence Zone), and exerts strong impacts on upstream climate variations from North Atlantic to West Asia. It also affects oceanic circulation and buoyancy fields via atmospheric stationary wave trains and air–sea interaction processes, contributing to formation of the Atlantic Meridional Overturning Circulation. The TP thermal state and atmospheric–oceanic conditions are highly interactive and Asian summer monsoon variability is controlled synergistically by internal TP variability and external forcing factors. [ABSTRACT FROM AUTHOR]

Downward continuation is a very useful technique in the interpretation of potential field data. It would enhance the short wavelength of the gravity anomalies or accentuate the details of the source distribution. Taylor series expansion method has been proposed to be one of the best downward continued methods. However, the method using high-order vertical derivatives leads to low accuracy and instability results in many cases. In this paper, we propose a new method using a combination of Taylor series expansion and upward continuation for computing vertical derivatives. This method has been tested on the gravitational anomaly of infinite horizontal cylinder in both cases with and without random noise for higher accurate and stable than Hilbert transform method and Laplace equation method, especially in the case of noise input data. This vertical derivative method is applied successfully to calculate the downward continuation according to Taylor series expansion method. The downward continuation is also tested on both complex synthetic models and real data in the East Vietnam Sea (South China Sea). The results reveal that by calculating this new vertical derivative, the downward continuation method gave higher accurate and stable than the previous downward continuation methods. [ABSTRACT FROM AUTHOR]

This paper investigates bond market development in Asia by exploring the determinants of firms’ decisions to issue public debt in a range of Asian economies. Using a novel database covering the period 1995 to 2007, we use comparable micro level panel of nine countries—China, Hong Kong SAR, Indonesia, Korea, Malaysia, Philippines, Singapore, Taiwan, and Thailand—to explore factors that promote bond issuance by firms. We control for firm characteristics and market features such as bond market depth and liquidity; we also consider supra-national policy initiatives to improve bond market function. Our paper demonstrates that regional initiatives have been an important step towards greater bond issuance by firms in Asia, mostly by fostering market deepening and improving liquidity. [ABSTRACT FROM PUBLISHER]

As a data-driven approach, the performance of deep learning models depends largely on the quantity and quality of the training data sets, which greatly limits the application of deep learning to tasks with small data sets. Unfortunately, sometimes we need to use limited small data sets to complete our tasks, such as distributed acoustic sensing (DAS) data denoising. However, using a small data set to train the network may cause overfitting, resulting in poor network generalization. To solve this problem, we propose an approach based on the combination of a generative adversarial network and a deep convolutional neural network. First, we used a small noise data set to train a generative adversarial network to generate synthetic noise samples, and then used these synthetic noise samples to augment the noise data set. Next, we used the augmented noise data set and the signal data set obtained through forward modelling to construct a synthetic training set. Finally, a denoising network based on a convolutional neural network was trained on the constructed synthetic training set. Experimental results show that the augmented data set can effectively improve the denoising performance and generalization ability of the network, and the denoising network trained on the augmented data set can more effectively reduce various kinds of noise in the DAS data. [ABSTRACT FROM AUTHOR]

Invasive species may occupy quite different environments in their invaded areas to native ones, which may intensively interfere with predicting potential distribution through ecological niche modeling (ENM). Here, we take the tomato leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), a tomato pest, as an example to investigate this topic. We analyzed niche expansion, stability, unfilling, and Schoener's D by principal component analysis (PCA) ordination method to examine its realized niche shifts and to explore how ENM approaches are affected by niche shifts. We used 5 datasets: Asian, African, European, South American, and global occurrence records in this study. Results showed that high niche unfilling for the species' invaded areas in Asia (20%), Africa (12%), and Europe (37%), possibly due to T. absoluta being in the early stages of invasion. High niche expansion was observed in Asia (38%) and Europe (19%), implying that some European and Asian populations had reached new climatic areas. African niche had the most niche stability (94%) and was equivalent to the native one in climate space (PCA ordination method), but the n -dimensional climate space framework showed that they were different. When projecting the native model to Asia and Europe, the native model performed poorly, implying that the niche shifts affected the transferability of the native model. ENM based on global data outperformed than other models, and our results suggested that T. absoluta has a large potential distribution in Asia, Mexico, South Europe, the United States, and Australia. Meanwhile, we recommend updating ENMs based on the species' invasion stage. [ABSTRACT FROM AUTHOR]

Background Accurate estimation of diarrhea incidence from facility-based surveillance requires estimating the population at risk and accounting for case patients who do not seek care. The Enterics for Global Health (EFGH) Shigella surveillance study will characterize population denominators and healthcare-seeking behavior proportions to calculate incidence rates of Shigella diarrhea in children aged 6–35 months across 7 sites in Africa, Asia, and Latin America. Methods The Enterics for Global Health (EFGH) Shigella surveillance study will use a hybrid surveillance design, supplementing facility-based surveillance with population-based surveys to estimate population size and the proportion of children with diarrhea brought for care at EFGH health facilities. Continuous data collection over a 24 month period captures seasonality and ensures representative sampling of the population at risk during the period of facility-based enrollments. Study catchment areas are broken into randomized clusters, each sized to be feasibly enumerated by individual field teams. Conclusions The methods presented herein aim to minimize the challenges associated with hybrid surveillance, such as poor parity between survey area coverage and facility coverage, population fluctuations, seasonal variability, and adjustments to care-seeking behavior. [ABSTRACT FROM AUTHOR]

This paper presents the results of our corroborated study of grassroots Internet sites and authors in the nation of Kyrgyzstan, exceptional in Central Asia for its deregulated Internet policy. The study presents a set of semistructured interviews with notable grassroots Internet authors and activists, including bloggers, forum participants, and journalists, and analyzes this data via a critical communication and media studies lens to point to significant implications on emergent social, cultural, and political movements in the nation. [ABSTRACT FROM AUTHOR]

The Kuqa earthquake occurred in a seismically active belt between the Tianshan Mountain and the Traim basin. Because of the sparse seismic network and complex crustal structure, it is very difficult to accurately locate the epicentre for this event using seismic waves. The epicentres located by different research groups vary over a spatial range of 20–40 km. Interferometric synthetic aperture radar (InSAR) is a geodetic technique with fine spatial resolution, good precision and wide coverage. An interferometric map of the epicentral region constrains the epicentre of this event. The arid climate and sparsely vegetation in the Kuqa region provide excellent conditions for InSAR studies. In this paper, we firstly construct a interferogram to map the coseismic deformation field due to the 1999 Kuqa earthquake using a coseismic interferometric pair of radar images acquired by the ESA ERS-2 satellite. Then, we develop a new geocoding method and apply it to the interferogram. Next, we infer the geometry of the seismogenic fault according to its focal mechanism and tectonic setting. To model the interferogram, we assume a dislocation buried in a uniform elastic half-space. Finally, we infer the epicentre of this earthquake to be located at (82.80°E, 41.92°N), which is close to the results of the National Earthquake Information Center of USGS and China Earthquake Administration. The epicentre location inferred from InSAR falls in the six-level isoseismal contour described by Xinjiang earthquake administration using the field investigations. [ABSTRACT FROM AUTHOR]

Background: The tobacco industry has formed regional environmental tobacco smoke (ETS) consultants programs in order to generate controversy on the issue of secondhand smoke (SHS) in Europe, Asia and Latin America. Only those countries in which the industry foresaw SHS restrictions were included. This paper describes the European and Asian components of the tobacco industry's worldwide ETS consultants program. Methods: A systematic search was carried out of tobacco industry documents available on the Internet between October 2002 and February 2004. Results: Beginning in 1987, Philip Morris assembled an international ETS consultants program in collaboration with other tobacco companies based on their market shares in different regions of the world. The law firm Covington & Burling contacted and hired consultants with a wide range of expertise, usually affiliated with an academic institution, in order to avoid direct contact with the industry. The objective of the program was to influence policy makers, media and the public by providing, through their consultants, 'accurate' (pro-industry) information concerning smoking regulations in public places and workplaces, indoor air quality and ventilation standards, and scientific claims regarding SHS. Consultants also conducted research related to SHS and organized and attended regional and international symposiums related to SHS without acknowledging industry funding. Conclusions: Despite evidence that the issue of smoke-free environments was close to emerging within the general public throughout the world in the late 1980s, the tobacco industry used its well-organized network of consultants to avoid SHS regulations in most of the world. [ABSTRACT FROM AUTHOR]

This paper presents two sets of arguments: one theoretical and one analytical. The theoretical arguments concern the relationship between regional ordering and systemic change. The paper questions the usefulness of the unipolar conception of the contemporary system arguing that the interaction of the Great Powers cannot be understood without reference to regional dynamics. Thus, a unipolar system implies considerable potential for U.S. hegemonic intervention at the regional level but in East Asia, we find an equilibrium constructed out of both material and normative forces, defined as a concert, which presents a considerable restraint on all powers, including the U.S. The paper then proceeds to examine these claims through an analysis of the foreign policies of the U.S., Russia, and China over the North Korean nuclear problem that emerged after 2002. It finds that China and Russia have substantive common interests arising from internal and external re-ordering in which they look to strategic partnerships, regional multilateralism, and systemic multipolarization as inter-locking processes. The paper finds that they have collaborated over the Korean crisis to prevent a U.S. unilateral solution but that this should not be construed as a success for an open counterhegemonic strategy as it was only under the constraining conditions of East Asian concert, including the dynamics within the U.S. alliance systems, that this collaboration was successful. Nevertheless, the paper concludes that regional multipolarity and systemic unipolarity are contradictory: a system that exhibits multipolarization at the regional level cannot be characterized as unipolar at the global level. [ABSTRACT FROM AUTHOR]

The Asian crisis provides heterodox economists with the opportunity to investigate counterfactually whether the financial policies they have proposed would have averted the crisis. The paper argues that neo-liberal financial integration introduces distinct risks to emerging economies—currency, flight, fragility, contagion and sovereignty risks. The paper presents the financial policies endorsed by the heterodoxy—transactions taxes, trip wires and/or speed bumps, convertibility restrictions, the Chilean model and a publicly managed mutual fund. The paper considers whether these policies mitigate risks, and whether they could have prevented the Asian crisis (and the transmission thereof). The paper concludes with policies to avert future crises. [ABSTRACT FROM AUTHOR]

In 2013 Indonesia, the world's fourth most populous country, declared that it would provide affordable health care for all its citizens within seven years. This crystallised an ambition first enshrined in law over five decades earlier, but never previously realised. This paper explores Indonesia's journey towards universal health coverage (UHC) from independence to the launch of a comprehensive health insurance scheme in January 2014. We find that Indonesia's path has been determined largely by domestic political concerns – different groups obtained access to healthcare as their socio-political importance grew. A major inflection point occurred following the Asian financial crisis of 1997. To stave off social unrest, the government provided health coverage for the poor for the first time, creating a path dependency that influenced later policy choices. The end of this programme coincided with decentralisation, leading to experimentation with several different models of health provision at the local level. When direct elections for local leaders were introduced in 2005, popular health schemes led to success at the polls. UHC became an electoral asset, moving up the political agenda. It also became contested, with national policy-makers appropriating health insurance programmes that were first developed locally, and taking credit for them. The Indonesian experience underlines the value of policy experimentation, and of a close understanding of the contextual and political factors that drive successful UHC models at the local level. Specific drivers of success and failure should be taken into account when scaling UHC to the national level. In the Indonesian example, UHC became possible when the interests of politically and economically influential groups were either satisfied or neutralised. While technical considerations took a back seat to political priorities in developing the structures for health coverage nationally, they will have to be addressed going forward to achieve sustainable UHC in Indonesia. [ABSTRACT FROM AUTHOR]

Background Mucormycosis is a potentially lethal mycosis. We reviewed peer-reviewed publications on mucormycosis to assess therapeutic outcomes. Methods A systematic literature search using the Ovid MEDLINE and EMBASE databases identified manuscripts describing human mucormycosis diagnosed according to European Organization for Research and Treatment of Cancer and the Mycoses Study Group criteria with therapeutic outcomes published from 2000 to 2022. Results In 126 articles, 10 335 patients were described, most from Asia (n = 6632, 66%). Diabetes was the most frequent underlying disease (n = 6188, 60%); 222 (2.1%) patients had no underlying diseases. The dominant clinical form was rhino-orbitocerebral (n = 7159, 69.3%), followed by pulmonary (n = 1062, 10.3%). Of 5364 patients with outcome data, amphotericin B monotherapy (n = 3749, mortality 31.5%) was most frequent, followed by amphotericin B + azole (n = 843, mortality 6.6%; P <.0001), amphotericin B followed by azole (n = 357, mortality 13.7%; P <.0001), posaconazole only (n = 250, mortality 17.2%; P <.0001), and isavuconazole only (n = 65, mortality 24.6%; P =.24). Duration and dose of antifungals varied widely. Documented outcomes from surgical resections in 149 patients found that 47 of 125 died (37.6%), compared with 16 of 24 (66.7%) patients who did not undergo surgery (P =.008). Conclusions Mucormycosis is more frequently reported in Asia than in Europe and is often linked to diabetes. Antifungal therapy, usually with surgery, is frequently effective for mucormycosis. [ABSTRACT FROM AUTHOR]

HY-2A is China's first satellite altimeter mission, launched in Aug. 2011. Its geodetic mission (GM) started from 2016 March 30 till present, collecting sea surface heights for about five 168-d cycles. To test how the HY-2A altimeter performs in marine gravity derivation, we use the least-squares collocation method to determine marine gravity anomalies on 1′ × 1′ grids around the South China Sea (covering 0°–30°N, 105°E–125°E) from the HY-2A/GM-measured geoid gradients. We assess the qualities of the HY-2A/GM-derived gravity over different depths and areas using the bias and tilt-adjusted ship-borne gravity anomalies from the U.S. National Centers for Environmental Information (NCEI) and the Second Institute of Oceanography, Ministry of Natural Resources (MNR) of P. R. China. The RMS difference between the HY-2A/GM-derived and the NCEI ship-borne gravity is 5.91 mGal, and is 5.33 mGal when replacing the HY-2A value from the Scripps Institution of Oceanography (SIO) V23.1 value. The RMS difference between the HY-2A/GM-derived and the MNR ship-borne gravity is 2.90 mGal, and is 2.76 mGal when replacing the HY-2A value from the SIO V23.1 value. The RMS difference between the HY-2A and SIO V23.1 value is 3.57 mGal in open sea areas at least 20 km far away from the coast. In general, the difference between the HY-2A/GM-derived gravity and ship-borne gravity decreases with decreasing gravity field roughness and increasing depth. HY-2A results in the lowest gravity accuracy in areas with islands or reefs. Our assessment result suggests that HY-2A can compete with other Ku-band altimeter missions in marine gravity derivation. [ABSTRACT FROM AUTHOR]

Background: The disease burden of pancreatic cancer in East Asia is at a high level, but the epidemiological characteristics of pancreatic cancer in the region have not been systematically studied. Method: Joinpoint analysis was used to identify average annual percentage change (AAPC) and annual percentage change (APC) in mortality. Age-period-cohort models were used to analyze age-period cohort effects across countries. Bayesian age-period-cohort (BAPC) analysis was used to project the burden of disease for 2020-2030. Results: Pancreatic cancer mortality in males in Japan (2012-2019, APC = −0.97) and Korea (2012-2019, APC = −0.91) has shown a decreasing trend since 2012 (P <.05). However, China (2016-2019, APC = 3.21), Mongolia (2015-2.019, APC = 2.37), and North Korea (2012-2019, APC = 0.47) showed a significant increase in pancreatic cancer in both genders (P <.05). Risk factors for pancreatic cancer in East Asia remained largely stable between 2010 and 2019. Mortality of pancreatic cancer due to smoking began to decline in areas with high socio-demographic index (SDI), and mortality of pancreatic cancer due to high body mass index and high fasting plasma glucose increased with SDI. The age-standardized mortality for pancreatic cancer in Chinese males is expected to exceed that of Japan and South Korea by 2030, but the disease burden of pancreatic cancer in Japan and South Korea remains at extremely high levels. Conclusion: Economically developed countries are beginning to show a decreasing trend in the burden of pancreatic cancer disease, and developing countries are experiencing a rapid increase in the age-standardized death rate (ASDR) of pancreatic cancer. Focusing on the disease burden of pancreatic cancer in East Asia, this study analyzed average annual percentage change and annual percentage change in mortality, age-period cohort effects across countries, and the projected burden of disease for 2020-2030. Results are presented here. [ABSTRACT FROM AUTHOR]

Analysis of ethnic differences in disease is complicated by the fact that culture has an effect on whether people identify themselves as ill and how often they use medical services. This paper cities evidence to show that use of selected medical services by older members of ethnic groups appears to be high. Although a relatively high amount of disease among minority ethnic groups partly accounts for this, additional explanations--notably, cultural perceptions of doctors and aspects of the ageing migrant's position in society--are suggested. [ABSTRACT FROM PUBLISHER]

While World Health Organization member countries embraced the concept of universal coverage as early as 2005, few low-income countries have yet achieved the objective. This is mainly due to numerous barriers that hamper access to needed health services. In this paper we provide an overview of the various dimensions of barriers to access to health care in low-income countries (geographical access, availability, affordability and acceptability) and outline existing interventions designed to overcome these barriers. These barriers and consequent interventions are arranged in an analytical framework, which is then applied to two case studies from Cambodia. The aim is to illustrate the use of the framework in identifying the dimensions of access barriers that have been tackled by the interventions. The findings suggest that a combination of interventions is required to tackle specific access barriers but that their effectiveness can be influenced by contextual factors. It is also necessary to address demand-side and supply-side barriers concurrently. The framework can be used both to identify interventions that effectively address particular access barriers and to analyse why certain interventions fail to tackle specific barriers. [ABSTRACT FROM AUTHOR]

The Global Financial Crisis (GFC) of 2008/2009 was the largest economic slowdown since the Great Depression. It undermined the growth and development prospects of developing countries. Several recent studies estimate the impact of economic shocks on the poor and vulnerable, especially women and children. Infant and child mortality rates are still likely to continue to decline, but at lower rates than would have been the case in the absence of the GFC.Asia faces special challenges. Despite having been the fastest growing region in the world for decades, and even before the current crisis, this region accounted for nearly 34% of global deaths of children under 5, more than 40% of maternal deaths and 60% of newborn deaths. Global development goals cannot be achieved without much faster and deeper progress in Asia.Current health financing systems in much of Asia are not well placed to respond to the needs of women and their children, or the recent global financial and economic slowdown. Public expenditure is often already too low, and high levels of out-of-pocket health expenditure are an independent cause of inequity and impoverishment for women and their children. The GFC highlights the need for reforms that will improve health outcomes for the poor, protect the vulnerable from financial distress, improve public expenditure patterns and resource allocation decisions, and so strengthen health systems.This paper aims to highlight the most recent assessments of how economic shocks, including the GFC, affect the poor in developing countries, especially vulnerable women and children in Asia. It concludes that conditional cash transfers, increasing taxation on tobacco and increasing the level, and quality, of public expenditure through well-designed investment programmes are particularly relevant in the context of an economic shock. That is because these initiatives simultaneously improve health outcomes for the poor and vulnerable, protect them from further financial distress, improve public financing and/or provide a much-needed counter-cyclical stimulus at times of economic slowdown. [ABSTRACT FROM AUTHOR]

The article discusses efforts implemented during and after World War Two that were intended to reconstruct and reorient patterns of inter-Asian migration. It is attested that Japanese conquests and the collapse of European imperialism transformed the political and social histories of many parts of Asia, thereby interrupting the mass migration of men from southern China and south India to the frontier regions of South East Asia. The paper urges that one of the central tenets in the process of nation-building that took place during the post-war reconstruction process posited that it was difficult to foster ethical citizenship within cultural plurality. This allegedly diminished Asia’s trend of migration until it resumed in the 1990s.

The primary purpose of this article is to propose general conditions for establishing a nuclear weapon-free zone (NWFZ) in the Korean Peninsula from the viewpoint of international law. North Korea's nuclear weapons development has created the most negative environment for the peace and security of Northeast Asia since the early 1990s. In spite of painstaking negotiations to denuclearize North Korea, the parties concerned have not found any fundamental solution yet. This interim failure is due to the uncompromising positions of the two sides as well as the inherently paradoxical structure of the Treaty on the Non-Proliferation of Nuclear Weapons, which legalizes the development of nuclear weapons by the recognized nuclear powers. The most reasonable solution is to completely and fairly denuclearize the whole Korean Peninsula under an NWFZ. This paper scrutinizes legal, political and technical problems for realizing the plan for a nuclear-free Korean Peninsula. In a world that all too often seems dark and ominous, the Treaty of Tlatelolco will shine like a beacon. This Treaty is a practical demonstration to all humanity of what can be accomplished when sufficient dedication and the necessary will exist.U Thant [ABSTRACT FROM PUBLISHER]

The paper attempts via case studies to illustrate the nature and importance of political structures and transitions in the course of rapid growth and development. The cases are drawn principally from Asia, where the pattern has often been a dominant single-party structure evolving into a full multi-party democratic structure. This results from the interaction of the politics and changes that result from the growth process itself, such as the emergence of politically active middle and entrepreneurial classes. The role of political leadership in managing, sequencing, and pacing these transitions is discussed. We do not yet have a general model for which these cases would be instances. The hope is that an in-depth understanding of the case dynamics will be a useful input to the development and testing of more general theories. [ABSTRACT FROM PUBLISHER]

Abstract: The paper compares healthcare reforms in China, South Korea, Singapore and Thailand with the purpose of drawing useable lessons about the appropriate role of the state in the sector. It argues that healthcare reforms in China and Korea offer many negative lessons for healthcare reformers while Singapore and Thailand offer positive lessons that may be considered for emulation elsewhere. The fundamental lesson to emerge from the successful reform experiences is that a large and active state role in various aspects of healthcare provision and financing is essential for containing expenditures and maintaining access. Public ownership of providers and prospective payments are particularly effective in controlling expenditures while direct government financing promotes equitable access. The cases also show that political economy matters: the Singapore and Thai states’ strong presence in the healthcare sector is a vital reason for their superior performance. [ABSTRACT FROM AUTHOR]

Uncontrolled burning or smoldering of coal seams, otherwise known as coal fires, represents a worldwide natural hazard. Efficient application of fire-fighting strategies and prevention of mining hazards require that the temporal evolution of fire propagation can be sufficiently precise predicted. A promising approach for the investigation of the temporal evolution is the numerical simulation of involved physical and chemical processes. In the context of the Sino-German Research Initiative ‘Innovative Technologies for Detection, Extinction and Prevention of Coal Fires in North China,’ a numerical model has been developed for simulating underground coal fires at large scales. The objective of such modelling is to investigate observables, like the fire propagation rate, with respect to the thermal and hydraulic parameters of adjacent rock. In the model, hydraulic, thermal and chemical processes are accounted for, with the last process complemented by laboratory experiments. Numerically, one key challenge in modelling coal fires is to circumvent the small time steps resulting from the resolution of fast reaction kinetics at high temperatures. In our model, this problem is solved by means of an ‘operator-splitting’ approach, in which transport and reactive processes of oxygen are independently calculated. At high temperatures, operator-splitting has the decisive advantage of allowing the global time step to be chosen according to oxygen transport, so that time-consuming simulation through the calculation of fast reaction kinetics is avoided. Also in this model, because oxygen distribution within a coal fire has been shown to remain constant over long periods, an additional extrapolation algorithm for the coal concentration has been applied. In this paper, we demonstrate that the operator-splitting approach is particularly suitable for investigating the influence of hydraulic parameters of adjacent rocks on coal fire propagation. A study shows that dynamic propagation strongly depends on permeability variations. For the assumed model, no fire exists for permeabilities , whereas the fire propagation velocity ranges between for , and drops to lower than for . Additionally, strong temperature variations are observed for the permeability range . [ABSTRACT FROM AUTHOR]

This study is part of a series of inquiries being made to ascertain the extent and practical usefulness of the part played by Asian nations in their individual and collective contribution to the norms-formulating functions of Asian States as members of the global community. The current paper is confined to the three areas of jurisdictional immunities in the practice of States under contemporary international law. The first part relates to Asian practice and the practice of other nations affecting Asian communities in regard to the Immunities of States and their Property from the jurisdiction of other national entities. The second part deals with the current practice of diplomatic and consular immunities, available also to ad hoc or Special Missions. The third part concerns the immunities accorded by States to international organizations or in connection with the exercise of their official functions. The final part contains concluding observations calling for meticulous care and attention to find a practical approach to the nature and extent of immunities needed and the necessity to maintain a delicate balance between the interests of the donors and recipients of immunities so as to avoid possible abuses. Asian and non-Asian nations alike are equally grantors and beneficiaries of immunities under review. [ABSTRACT FROM AUTHOR]

In this paper, the ways in which HIV is transmitted and factors facilitating transmission are described, although we still do not fully understand why the HIV epidemic has spread so heterogeneously across the globe. Estimates of HIV prevalence vary in quality but give some idea of trends in different countries and regions. Of all regions in the world, sub-Saharan Africa is the hardest hit by HIV, containing around 70% of people living with HIV/AIDS. There are, however, recent signs of hope in Africa due to a slight reduction in the number of new HIV cases in the year 2000. Most countries in Asia have not seen explosive epidemics in the general population up to now but patterns of injecting drug use (IDU) and sex work are conducive to the spread of HIV so there is no room for complacency. Unpredictable epidemics among IDU in the former Soviet Union have the potential to spread into the general population. Some countries in Central America and the Caribbean have growing HIV epidemics with adult prevalences second only to sub-Saharan Africa. Reductions in morbidity and mortality through the use of highly active antiretroviral therapy are at present limited to high-income and some Latin American countries. Both the cost of these therapies and the poor health care delivery systems in many affected countries need to be addressed before antiretrovirals can benefit the majority of people living with HIV/AIDS. [ABSTRACT FROM PUBLISHER]

SUMMARY: On the 9th of January 2020, an Mw 6.4 strike-slip earthquake took place north of the Asian margin of the Bering Sea. The earthquake occurred within the known reverse-right-lateral active fault zone, called Khatyrka–Vyvenka, which transverses the Koryak Highland from SE to NW and is thought to be a surface manifestation of the Asian portion of either the Bering plate boundary or the northern edge of the Alaskan stream. No other strong earthquake has ever been recorded in this remote uninhabited area and the few existing seismic stations provide poor quality earthquake locations. We adopt SAR interferometry (InSAR) technique to define an improved location of the Koryak 2020 earthquake and constrain the seismic source. The analysis of the 2020 event revealed a previously unknown active fault of left-lateral kinematics that is possibly hidden and strikes NW transversely to the Khatyrka–Vyvenka fault zone. Although several mechanisms could account for left-lateral kinematics of this fault, we propose that the structure is part of a more extended NW fault structure, that formed in pre-neotectonic times and has played a role of a pre-existing rheological discontinuity. This revived NW structure together with a similar structure located easterly, so far aseismic, make the plate/stream boundary segmented, step-like in plan view. The step-like boundary geometry may be the result of internal transform deformation of a rigid plate, but it is better explained by deflections of the Alaskan stream edge at local crustal asperities, which are pre-Cenozoic terrains. [ABSTRACT FROM AUTHOR]

The microsporidian, Nosema maddoxi Becnel, Solter, Hajek, Huang, Sanscrainte & Estep, infects brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), populations in North America and Asia and causes decreased fitness in infected insects. This host overwinters as adults, often in aggregations in sheltered locations, and variable levels of mortality occur over the winter. We investigated pathogen prevalence in H. halys adults before, during, and after overwintering. Population level studies resulted in detection of N. maddoxi in H. halys in 6 new US states, but no difference in levels of infection by N. maddoxi in autumn versus the following spring. Halyomorpha halys that self-aggregated for overwintering in shelters deployed in the field were maintained under simulated winter conditions (4°C) for 5 months during the 2021–2022 winter and early spring, resulting in 34.6 ± 4.8% mortality. Over the 2020–2021 and 2021–2022 winters, 13.4 ± 3.5% of surviving H. halys in shelters were infected with N. maddoxi , while N. maddoxi infections were found in 33.4 ± 10.8% of moribund and dead H. halys that accumulated in shelters. A second pathogen, Colletotrichum fioriniae Marcelino & Gouli, not previously reported from H. halys , was found among 46.7 ± 7.8% of the H. halys that died while overwintering, but levels of infection decreased after overwintering. These 2 pathogens occurred as co-infections in 11.1 ± 5.9% of the fungal-infected insects that died while overwintering. Increasing levels of N. maddoxi infection caused epizootics among H. halys reared in greenhouse cages after overwintering. [ABSTRACT FROM AUTHOR]

A sequence of three strong (M W7.2, 6.4, 6.6) earthquakes struck the Pamir of Central Asia in 2015–2017. With a local seismic network, we recorded the succession of the foreshock, main shock and aftershock sequences at local distances with good azimuthal coverage. We located 11 784 seismic events and determined 33 earthquake moment tensors. The seismicity delineates the tectonic structures of the Pamir in unprecedented detail, that is the thrusts that absorb shortening along the Pamir's thrust front, and the strike-slip and normal faults that dissect the Pamir Plateau into a westward extruding block and a northward advancing block. Ruptures on the kinematically dissimilar faults were activated subsequently from the initial M W 7.2 Sarez event at times and distances that follow a diffusion equation. All main shock areas but the initial one exhibited foreshock activity, which was not modulated by the occurrence of the earlier earthquakes. Modelling of the static Coulomb stress changes indicates that aftershock triggering occurred over distances of ≤90 km on favourably oriented faults. The third event in the sequence, the M W 6.6 Muji earthquake, ruptured despite its repeated stabilization through stress transfer in the order of –10 kPa. To explain the accumulation of M W > 6 earthquakes, we reason that the initial main shock may have increased nearby fault permeability, and facilitated fluid migration into the mature fault zones, eventually triggering the later large earthquakes. [ABSTRACT FROM AUTHOR]

The performance of supervised deep learning-based denoising methods relies on massive amounts of high-quality training data set with labels. However, data labelling is a time-consuming and tedious process, and the lack of labelled data set has become a major bottleneck affecting the development of supervised deep learning-based denoising methods. In recent years, denoising methods that only use unlabelled noisy data set for training have received more and more attention. Although these methods get rid of the dependence on labels, they usually have some specific requirements on the training data set. For example, the paired training data are required to be multiple noisy observations for each scene or obey a specific noise distribution, etc., which are often very challenging to meet in practical applications. In this study, we propose an improved self-supervised denoising framework based on Noise2Noise that only uses noisy seismic data set for training, and we name it sample2sample. The proposed denoising framework does not require multiple repeated acquisitions of seismic data to obtain multiple independent noisy observations for each scene used for training, and has no specific requirement for the noise distribution prior. Specifically, we introduce a random sampler to generate paired subsamples from some individual noisy seismic data for training. The corresponding elements in the two paired subsamples are adjacent in the original seismic data and approximately meet the training premise of Noise2Noise, that is the paired training data have the same signal. In addition, considering that there are some subtle differences in the signals of the paired subsamples generated by sampling, we also introduce a regularization loss to compensate for this. We conducted a qualitative and quantitative analysis of the denoising performance of the proposed method through further experiments, including synthetic data experiments and field data experiments. [ABSTRACT FROM AUTHOR]

Policy design, or the deliberate governmental effort to attain desired policy objectives, is an integral part of micro and macro-level fiscal and financial regulation. This paper seeks to address the role of regime coherence and policy capacity in contributing to effective financial policy design. Drawing on the cases of the Global Financial Crisis and Asian Financial Crisis and focusing on Asian states, we assess regime capacity at both international and domestic levels. We argue that it is the integration of analytical, operational and political capacities that have contributed to the overall ability of a government regime to address and respond to crises. [ABSTRACT FROM AUTHOR]

The hydraulic traits of a plant species may reflect its climate adaptations. Southwest China is considered as a biodiversity hotpot of the genus Quercus (oak). However, the hydraulic adaptations of Asian oaks to their climate niches remain unclear. Ten common garden-grown oak species with distinct natural distributions in eastern Asia were used to determine their stem xylem embolism resistance (water potential at 50% loss of hydraulic conductivity, P 50), stem hydraulic efficiency (vessel anatomy and sapwood specific hydraulic conductivity (K s)) and leaf anatomical traits. We also compiled four key functional traits: wood density, hydraulic-weighted vessel diameter, K s and P 50 data for 31 oak species from previous literature. We analyzed the relationship between hydraulic traits and climatic factors over the native ranges of 41 oak species. Our results revealed that the 10 Asian oak species, which are mainly distributed in humid subtropical habitats, possessed a stem xylem with low embolism resistance and moderate hydraulic efficiency. The deciduous and evergreen species of the 10 Asian oaks differed in the stem and leaf traits related to hydraulic efficiency. K s differed significantly between the two phenological groups (deciduous and evergreens) in the 41-oak dataset. No significant difference in P 50 between the two groups was found for the 10 Asian oaks or the 41-oak dataset. The oak species that can distribute in arid habitats possessed a stem xylem with high embolism resistance. K s negatively related to the humidity of the native range of the 10 Asian oaks, but showed no trend when assessing the entire global oak dataset. Our study suggests that stem hydraulic conductivity and embolism resistance in Quercus species are shaped by their climate niche. Our findings assist predictions of oak drought resistance with future climate changes for oak forest management. [ABSTRACT FROM AUTHOR]

Vigna reflexo-pilosa (créole bean) is a wild legume belonging to the subgenus Ceratoropis and is widely distributed in Asia. Créole bean is the only tetraploid species in the genus Vigna , and it has been shown to derive from the hybridization of Vigna hirtella and Vigna trinervia. In this study, we combined the long-read PacBio technology with the chromatin contact mapping (Hi-C) technique to obtain a chromosome-level assembly of V. reflexo-pilosa. The final assembly contained 998,724,903 bases with an N50 length of 42,545,650 bases. Our gene prediction recovered 99.4% of the highly conserved orthologs based on the BUSCO analysis. To investigate homoeolog expression bias and expression level dominance in the tetraploid, we also sequenced and assembled the genomes of its progenitors. Overall, the majority of the homoeolog pairs (72.9%) displayed no expression bias, and among those that exhibited biased expression, 16.3% showed unbalanced homoeolog expression bias toward the V. trinervia subgenome. Moreover, 41.2% and 36.2% of the expressed gene pairs exhibited transgressive expression and expression level dominance, respectively. Interestingly, the genome-wide expression level dominance in the tetraploid was biased toward the V. trinervia subgenome. The analysis of methylation patterns also revealed that the average methylation levels in coding regions were higher in the V. hirtella subgenome than those in the V. trinervia subgenome. The genomic/transcriptomic resources for these three species are useful not only for the development of elite cultivars in Vigna breeding programs but also to researchers studying comparative genomics and investigating genomic/epigenomic changes following polyploid events. [ABSTRACT FROM AUTHOR]

The M w 7.9 2015 April 25 Gorkha earthquake is the latest of a millenary-long series of large devastating Himalayan earthquakes. It is also the first time a large Himalayan earthquake and its aftershocks were recorded by a local network of seismic stations. In the 5 yr following the main shock, more than 31 000 aftershocks were located by this permanent network within the ruptured area, including 14 362 events with M L greater than 2.5, 7 events with M L > 6, including one large aftershock with M w 7.2 on 2015 May 12. In 2020, 5 yr after the main shock, the seismicity rate along the ruptured fault segments was still about 5 times higher than the background seismicity before the Gorkha earthquake. Several bursts of earthquakes, sometimes organized in clusters, have been observed from a few days to several years after the main shock. Some of these clusters were located at the same place as the clusters that happened during the decades of interseismic stress build-up that preceded the large earthquake. They also happened in the vicinity of the high frequency seismic bursts that occurred during the main shock. These heterogeneities contribute to a persistent segmentation of the seismicity along strike, possibly controlled by geological structural complexities of the Main Himalayan Thrust fault. We suggest that these pre-2015 clusters revealed the seismo-geological segmentation that influences both the coseismic rupture and the post-seismic relaxation. [ABSTRACT FROM AUTHOR]

Bradysia odoriphaga (Diptera: Sciaridae) is a major insect pest of seven plant families including 30 commercial crops in Asia. The long-term use of chemical pesticides leads to problems such as insect resistance, environmental issues, and food contamination. Against this background, a novel pest control method should be developed. In insects, odorant-binding proteins (OBPs) transport odor molecules, including pheromones and plant volatiles, to olfactory receptors. Here, we expressed and characterized the recombinant B. odoriphaga OBP BodoOBP10, observing that it could bind the sulfur-containing compounds diallyl disulfide and methyl allyl disulfide with Ki values of 8.01 μM and 7.00 μM, respectively. Homology modeling showed that the BodoOBP10 3D structure was similar to that of a typical OBP. Both diallyl disulfide and methyl allyl disulfide bound to the same site on BodoOBP10, mediated by interactions with six hydrophobic residues Met70, Ile75, Thr89, Met90, Leu93, and Leu94, and one aromatic residue, Phe143. Furthermore, silencing BodoOBP10 expression via RNAi significantly reduced the electroantennogram (EAG) response to diallyl disulfide and methyl allyl disulfide. These findings suggest that BodoOBP10 should be involved in the recognition and localization of host plants. [ABSTRACT FROM AUTHOR]

We reviewed recent literature to identify the positive and negative effects of thinning on both stand- and tree-level resistance and resilience to four stressors that are expected to increase in frequency and/or severity due to global change: (1) drought, (2) fire, (3) insects and pathogens, and (4) wind. There is strong evidence that thinning, particularly heavy thinning, reduces the impact of drought and also the risk and severity of fire when harvest slash is burned or removed. Thinning also increases the growth and vigor of residual trees, making them less susceptible to eruptive insects and pathogens, while targeted removal of host species, susceptible individuals and infected trees can slow the spread of outbreaks. However, the evidence that thinning has consistent positive effects is limited to a few insects and pathogens, and negative effects on root rot infection severity were also reported. At this point, our review reveals insufficient evidence from rigorous experiments to draw general conclusions. Although thinning initially increases the risk of windthrow, there is good evidence that thinning young stands reduces the long-term risk by promoting the development of structural roots and favouring the acclimation of trees to high wind loads. While our review suggests that thinning should not be promoted as a tool that will universally increase the resistance and resilience of forests, current evidence suggests that thinning could still be an effective tool to reduce forest vulnerability to several stressors, creating a window of opportunity to implement longer term adaptive management strategies such as assisted migration. We highlight knowledge gaps that should be targeted by future research to assess the potential contribution of thinning to adaptive forest management. One of these gaps is that studies from boreal and tropical regions are drastically underrepresented, with almost no studies conducted in Asia and the southern hemisphere. Empirical evidence from these regions is urgently needed to allow broader-scale conclusions. [ABSTRACT FROM AUTHOR]