1. Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease.
- Author
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Niihata, Kakuya, Tomosugi, Naohisa, Uehata, Takuya, Shoji, Tatsuya, Mitsumoto, Kensuke, Shimizu, Morihiro, Kawabata, Hiroaki, Sakaguchi, Yusuke, Suzuki, Akira, Hayashi, Terumasa, Okada, Noriyuki, Isaka, Yoshitaka, Rakugi, Hiromi, and Tsubakihara, Yoshiharu
- Subjects
DISEASE progression ,HEPCIDIN ,RENAL anemia ,SERUM ,HEMODIALYSIS ,CHRONIC kidney failure ,ERYTHROPOIESIS - Abstract
Background Hepcidin is associated with iron-restricted erythropoiesis. A previous cross-sectional study showed that serum hepcidin-25 levels are negatively associated with the hemoglobin concentration in non-dialysis chronic kidney disease (CKD) patients with sufficient iron stores. This longitudinal study aimed at ascertaining the association between hepcidin-25 levels and the progression of renal anemia. Methods We selected 335 non-dialysis CKD patients who showed hemoglobin concentrations >10 g/dL and who were not receiving erythropoiesis-stimulating agent (ESA) therapy, from among the subjects of our previous study, who had been recruited between February and June 2007 in a previous study. The primary outcome was the start of the ESA therapy or hemoglobin concentrations remaining below 10 g/dL for >3 months, by 31 December 2010. The patients were classified into high- and low-ferritin groups depending on their median ferritin levels. The Cox proportional hazard model with restricted cubic spline curve analysis was used to determine the association between hepcidin-25 levels and the outcome for each group. Results The hepcidin-25 level was a significant predictor both for the high-ferritin group (P = 0.04, linearity = 0.02) and for the low-ferritin group (P = 0.04, linearity P = 0.02). The spline curve for the high-ferritin group showed that higher hepcidin-25 levels had a high log-relative hazard. Conclusions Higher hepcidin-25 levels predict the progression of anemia in non-dialysis CKD patients with sufficient iron stores, indicating the involvement of hepcidin in the progression of anemia in non-dialysis CKD patients. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
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