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Focuses on the conventional genotyping of human immunodeficiency virus type 1 from a drug-resistant genotype. Use of an ultrasensitive real-time polymerase chain reaction; Detection of minority resistant populations in the plasma of patients; Combination of nucleoside and nonnucleoside reverse-transcriptase inhibitors.

An abstract of the article "Alveolar and Blood T Lymphocyte Profiles in Pneumocystis jirovecii Positive Patients: Effects of HIV Status," by Xavier Iriart and colleagues is presented.

Two black African immigrants, with no history of recent travel outside France, received a diagnosis of a malignant lymphoproliferative disorder and splenomegaly, and they subsequently underwent splenectomy. A few weeks after surgery, both patients experienced an acute episode of Plasmodium falciparum malaria, so the initial diagnosis was corrected retrospectively and changed to hyperreactive malarial splenomegaly. These cases illustrate the difficulty in distinguishing hyperreactive malarial splenomegaly from malignant lymphoproliferative disorders and therefore underline the role of the spleen in the immune system's defense against malaria. [ABSTRACT FROM AUTHOR]