1. Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography.
- Author
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Watt, Gordon P, Keshavamurthy, Krishna N, Nguyen, Tuong L, Lobbes, Marc B I, Jochelson, Maxine S, Sung, Janice S, Moskowitz, Chaya S, Patel, Prusha, Liang, Xiaolin, Woods, Meghan, Hopper, John L, Pike, Malcolm C, and Bernstein, Jonine L
- Subjects
BREAST cancer ,MAMMOGRAMS - Abstract
Women with high mammographic density have an increased risk of breast cancer. They may be offered contrast-enhanced mammography to improve breast cancer screening performance. Using a cohort of women receiving contrast-enhanced mammography, we evaluated whether conventional and modified mammographic density measures were associated with breast cancer. Sixty-six patients with newly diagnosed unilateral breast cancer were frequency matched on the basis of age to 133 cancer-free control individuals. On low-energy craniocaudal contrast-enhanced mammograms (equivalent to standard mammograms), we measured quantitative mammographic density using CUMULUS software at the conventional intensity threshold ("Cumulus") and higher-than-conventional thresholds ("Altocumulus," "Cirrocumulus"). The measures were standardized to enable estimation of odds ratio per adjusted standard deviation (OPERA). In multivariable logistic regression of case-control status, only the highest-intensity measure (Cirrocumulus) was statistically significantly associated with breast cancer (OPERA = 1.40, 95% confidence interval = 1.04 to 1.89). Conventional Cumulus did not contribute to model fit. For women receiving contrast-enhanced mammography, Cirrocumulus mammographic density may better predict breast cancer than conventional quantitative mammographic density. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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