1. Neutrophilic Myeloid-Derived Suppressor Cells and Severity in SARS-CoV-2 Infection.
- Author
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Omar, Mona A, Hawary, Rabab El, Eldash, Alia, Sadek, Khaled M, Soliman, Neveen A, Hanna, Mariam Onsy F, and Shawky, Shereen M
- Subjects
ANTIBIOTICS ,THERAPEUTIC use of immunoglobulins ,RISK assessment ,OXYGEN saturation ,FLOW cytometry ,ACADEMIC medical centers ,PATIENTS ,HOSPITAL care ,LYMPHOPENIA ,COVID-19 testing ,POLYMERASE chain reaction ,CELL proliferation ,SEVERITY of illness index ,MYELOID-derived suppressor cells ,SYMPTOMS ,DESCRIPTIVE statistics ,TREATMENT effectiveness ,CELL lines ,CLASSIFICATION ,ODDS ratio ,ANGIOTENSIN converting enzyme ,AGING ,DISEASE complications ,INFLAMMATION ,COMPARATIVE studies ,CONFIDENCE intervals ,DATA analysis software ,COVID-19 ,IMMUNOSUPPRESSION ,C-reactive protein ,SARS-CoV-2 ,IMMUNITY ,EVALUATION - Abstract
Background While we strive to live with SARS-CoV-2, defining the immune response that leads to recovery rather than severe disease remains highly important. COVID-19 has been associated with inflammation and a profoundly suppressed immune response. Objective To study myeloid-derived suppressor cells (MDSCs), which are potent immunosuppressive cells, in SARS-CoV-2 infection. Results Patients with severe and critical COVID-19 showed higher frequencies of neutrophilic (PMN)–MDSCs than patients with moderate illness and control individuals (P =.005). Severe disease in individuals older and younger than 60 years was associated with distinct PMN-MDSC frequencies, being predominantly higher in patients of 60 years of age and younger (P =.004). However, both age groups showed comparable inflammatory markers. In our analysis for the prediction of poor outcome during hospitalization, MDSCs were not associated with increased risk of death. Still, patients older than 60 years of age (odds ratio [OR] = 5.625; P =.02) with preexisting medical conditions (OR = 2.818; P =.003) showed more severe disease and worse outcome. Among the immunological parameters, increased C-reactive protein (OR = 1.015; P =.04) and lymphopenia (OR = 5.958; P =.04) strongly identified patients with poor prognosis. Conclusion PMN-MDSCs are associated with disease severity in COVID-19; however, MDSC levels do not predict increased risk of death during hospitalization. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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