1. Young at heart: a DNA methylation's tale.
- Author
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Mongelli, Alessia, Farsetti, Antonella, and Gaetano, Carlo
- Subjects
DNA methylation ,DIOXYGENASES ,DNA repair - Abstract
At the molecular level, the consequence of aging is also complex and multifaceted and includes loss of proteostasis, genomic instability, telomere attrition, and various epigenetic alterations, such as changes in genomic DNA methylation. Post-natal enriched oxygenation activates the DNA damage response that inhibits the cardiomyocyte's cell cycle, possibly causing a slower telomere length shortening than leucocytes.[9] In addition, the post-natal metabolism is quite different among the two cell types. Aging is an incessant and unavoidable process that affects all organisms from birth to death. [Extracted from the article]
- Published
- 2023
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