1. Genomic Evidence for the Nonpathogenic State in HIV-1–Infected Northern Pig-Tailed Macaques.
- Author
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Pang, Wei, Shao, Yong, Zhuang, Xiao-Lin, Lu, Ying, He, Wen-Qiang, Zheng, Hong-Yi, Xin, Rong, Zhang, Ming-Xu, Zhang, Xiao-Liang, Song, Jia-Hao, Tian, Ren-Rong, Shen, Fan, Li, Yi-Hui, Zhao, Zu-Jiang, Wu, Dong-Dong, and Zheng, Yong-Tang
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MACAQUES ,GENOMICS ,ANIMAL models in research ,TOLL-like receptors ,SWINE breeding ,HIV ,INTERFERON alpha - Abstract
HIV-1 is a highly host-specific retrovirus that infects humans but not most nonhuman primates. Thus, the lack of a suitable primate model that can be directly infected with HIV-1 hinders HIV-1/AIDS research. In the previous study, we have found that the northern pig-tailed macaques (NPMs) are susceptible to HIV-1 infection but show a nonpathogenic state. In this study, to understand this macaque–HIV-1 interaction, we assembled a de novo genome and longitudinal transcriptome for this species during the course of HIV-1 infection. Using comparative genomic analysis, a positively selected gene, Toll-like receptor 8, was identified with a weak ability to induce an inflammatory response in this macaque. In addition, an interferon-stimulated gene, interferon alpha inducible protein 27, was upregulated in acute HIV-1 infection and acquired an enhanced ability to inhibit HIV-1 replication compared with its human ortholog. These findings coincide with the observation of persistently downregulated immune activation and low viral replication and can partially explain the AIDS-free state in this macaque following HIV-1 infection. This study identified a number of unexplored host genes that may hamper HIV-1 replication and pathogenicity in NPMs and provided new insights into the host defense mechanisms in cross-species infection of HIV-1. This work will facilitate the adoption of NPM as a feasible animal model for HIV-1/AIDS research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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