1. Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.
- Author
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Jing XU, Ping GUO, Cuizhou LIU, Zhanping SUN, Liping GUI, Yuanqiang GUO, YAMAKUNI, Tohru, and OHIZUMI, Yasushi
- Subjects
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DITERPENES , *NEUROPROTECTIVE agents , *NEURAL circuitry , *NEUROBLASTOMA , *CELL death , *THERAPEUTICS , *NEUROLOGICAL disorders - Abstract
The article discusses research which examines the neuroprotective effects of kaurane diterpene isolated from the bulbs of Fritillaria ebeiensis against MPP+-induced neural cell death in human dopaminergic neuroblastomoa SH-SY5Y cells. The study showed that the structure of kaurane diterpenes were elucited on the basis of extensive spectroscopic analyses. It indicated the importance of diterpenoids that possessed biological activity for treating neurological disorders.
- Published
- 2011
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