1. Hepatitis C Virus Quasi-Species Dynamics Predict Progression of Fibrosis after Liver Transplantation.
- Author
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Arenas, Juan I., Gallegos-Orozco, Juan F., Laskus, Tomasz, Wilkinson, Jeff, Khatib, Amer, Fasola, Carlos, Adair, Debra, Radkowski, Marek, Kibler, Karen W., Nowicki, Marek, Douglas, David, Williams, James, Netto, George, Mulligan, David, Klintmalm, Goran, Rakela, Jorge, and Vargas, Hugo E.
- Subjects
HEPATITIS C ,LIVER transplantation ,VIRUS disease transmission ,DISEASE relapse ,HEALTH outcome assessment - Abstract
The dynamics of hepatitis C virus (HCV) quasi species in the E2 region may correlate with the course of infection after orthotopic liver transplantation (OLT). Complexity was higher in group 1 patients than in group 2 patients before OLT (P < .02) and at 1 week after OLT (P < .04). Diversity decreased in group 1 at transmission, as measured by either SE (P < .01) or MMS (P < .04). However, diversity increased in this group after OLT, as measured by SE (P < .03) ) or MMS (P < .02). FS at 1 year after OLT correlated with transmission changes, as measured by SE (re = 0.642, P < .0001) and MMS (r = 0.443, P < .04), and with post-OLT changes (for SE: r = -0.583, P < .01; for MMS: r = -0.536, P < .01). HCV complexity and diversity in the E2 region correlated with the severity of recurrence of HCV infection after OLT. Increased diversity of quasi species at transmission correlated with a higher FS at 1 year. However, increased diversity of quasi species in the post-OLT period correlated with a lower FS at 1 year. The dynamics of HCV quasi species in patients who undergo transplantation are predictive of outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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