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Keywords: Altitude; systemic blood pressure; sex differences EN Altitude systemic blood pressure sex differences 1 2 2 08/24/22 20220701 NES 220701 Teaser Proper regulation of the systemic blood pressure is crucial for human health and may be affected in changing environmental conditions, e.g. during high-altitude exposure. Travelling to high altitude, i.e. >2500 m, increases systemic blood pressure (BP) at rest and during exercise in normotensive and hypertensive subjects.[1] Although sex differences in BP regulation are well established,[2] evidence on the interaction with acute high-altitude exposure is scarce. Heart rate (HR) and peripheral oxygen saturation (SpO SB 2 sb ) were determined by finger pulse oximetry (Onyx, NONIN) and systemic BP by the use of a wrist blood pressure monitor (OMRON R3). [Extracted from the article]

Cannabinoids are multitarget substances. Currently available are dronabinol (synthetic delta-9-tetrahydrocannabinol, THC), synthetic cannabidiol (CBD) the respective substances isolated and purified from cannabis, a refined extract, nabiximols (THC:CBD = 1.08:1.00); and nabilone, which is also synthetic and has properties that are very similar to those of THC. Cannabinoids have a role in the treatment of cancer as palliative interventions against nausea, vomiting, pain, anxiety, and sleep disturbances. THC and nabilone are also used for anorexia and weight loss, whereas CBD has no orexigenic effect. The psychotropic effects of THC and nabilone, although often undesirable, can improve mood when administered in low doses. CBD has no psychotropic effects; it is anxiolytic and antidepressive. Of particular interest are glioma studies in animals where relatively high doses of CBD and THC demonstrated significant regression of tumor volumes (approximately 50% to 95% and even complete eradication in rare cases). Concomitant treatment with X-rays or temozolomide enhanced activity further. Similarly, a combination of THC with CBD showed synergistic effects. Although many questions, such as on optimized treatment schedules, are still unresolved, today's scientific results suggest that cannabinoids could play an important role in palliative care of brain tumor patients. [ABSTRACT FROM AUTHOR]

Annually, thousands of air travellers visit high altitude destinations to enjoy hiking tours to attractions in surrounding areas. However, many of them are not adequately trained, not sufficiently acclimatized and/or may suffer from pre-existing diseases. To prevent adverse health effects and unpleasant experiences at high altitude, simple submaximal exercise testing at low altitude for the prediction of exercise tolerance at high altitude would be helpful. Therefore, 40 healthy males and females performed submaximal exercise tests at low (600 m) and high altitude (3500 m). We demonstrate that exercise tolerance during acute exposure to high altitude can be predicted by the individual heart rate response to submaximal exercise assessed at low altitude. [ABSTRACT FROM AUTHOR]