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Porokeratosis is a clonal epidermal disorder of keratinization characterized by annular lesions with an atrophic centre and a hyperkeratotic edge. The cornoid lamella is the histopathological hallmark. Six clinical variants are recognized: porokeratosis of Mibelli; disseminated superficial porokeratosis; disseminated superficial actinic porokeratosis ( DSAP); porokeratosis plantaris et palmaris disseminata; punctate porokeratosis and linear porokeratosis. Linear porokeratosis is the type most frequently associated with malignant transformation into squamous cell carcinoma ( SCC). It is thought to represent a mosaic form of DSAP and has an incidence of less than 1 in 200 000; treatment options are limited. We describe a patient with systematized linear porokeratosis and multiple SCCs who was successfully treated with bleomycin electrochemotherapy ( ECT), a form of intralesional chemotherapy. In view of their large number, the individual SCCs were treated with bleomycin ECT. One year post-treatment the patient remains tumour free. To our knowledge, this is the first case of multiple SCCs treated by ECT in the context of systematized linear porokeratosis. Our case highlights the challenges associated with diagnosing and managing this unusual form of porokeratosis. [ABSTRACT FROM AUTHOR]

The article focuses on significance of palliative electrochemotherapy (ECT) treatment option for metastatic malignant melanoma. Topics discussed include consideration of ECT as an appropriate treatment approach by the Great Britain's National Institute for Health & Clinical Excellence for skin metastases; observation of an increment in demands for cytostatic drugs such as bleomycin; and assistance of ECT in reservation of systemic therapies.

A letter to the editor is presented regarding the topical liposomal delivery systems particularly the penetrative capacities of liposomal mithramycin in explanted keloids.

The article presents case studies of two patients, a 77-year-old woman with nodular lesion in the left leg and a 79-year-old woman with a longstanding ulcer on the right lower leg, who had eccrine porocarcinoma (EP). The two patients were diagnosed of different pathogenesis, have undergone wide local excision, and died of different haematological disorders. The diagnosis of EP and mortality rate of the patients are analyzed.

Presents a letter to the editor on the use of sentinel node biopsy in the management of primary cutaneous melanoma.