Search

Background Antimicrobial resistance poses a significant threat to public health globally. We studied the prevalence of colonization with extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE), carbapenem-resistant Enterobacterales (CRE), and colistin-resistant Enterobacterales (Col-RE) in hospitals and the surrounding community in South India. Methods Adults from 2 hospitals and the catchment community who consented to provide stool specimens were enrolled. Stools were plated on CHROMagar selective for ESCrE, CRE, and Col-RE. Bacterial identification and antibiotic susceptibility testing were done using Vitek 2 Compact and disc diffusion testing. Colistin broth microdilution was performed for a subset of isolates. Prevalence estimates were calculated with 95% confidence intervals (CIs), and differences were compared across populations using the Pearson χ 2 or Fisher exact test. Results Between November 2020 and March 2022, 757 adults in the community and 556 hospitalized adults were enrolled. ESCrE colonization prevalence was 71.5% (95% CI, 68.1%–74.6%) in the community and 81.8% (95% CI, 78.4%–84.8%) in the hospital, whereas CRE colonization prevalence was 15.1% (95% CI, 12.7%–17.8%) in the community and 22.7% (95% CI, 19.4%–26.3%) in the hospital. Col-RE colonization prevalence was estimated to be 1.1% (95% CI,.5%–2.1%) in the community and 0.5% (95% CI,.2%–1.6%) in the hospital. ESCrE and CRE colonization in hospital participants was significantly higher compared with community participants (P <.001 for both). Conclusions High levels of colonization with antibiotic-resistant Enterobacterales were found in both community and hospital settings. This study highlights the importance of surveillance of colonization in these settings for understanding the burden of antimicrobial resistance. [ABSTRACT FROM AUTHOR]

The Planck All-Sky Survey to Analyze Gravitationally-lensed Extreme Starbursts project aims to identify a population of extremely luminous galaxies using the Planck all-sky survey and to explore the nature of their gas fuelling, induced starburst, and the resulting feedback that shape their evolution. Here, we report the identification of 22 high-redshift luminous dusty star-forming galaxies (DSFGs) at z  = 1.1–3.3 drawn from a candidate list constructed using the Planck Catalogue of Compact Sources and Wide-field Infrared Survey Explorer all-sky survey. They are confirmed through follow-up dust continuum imaging and CO spectroscopy using AzTEC and the Redshift Search Receiver on the Large Millimeter Telescope Alfonso Serrano. Their apparent infrared luminosities span (0.1–3.1) × 1014 L⊙ (median of 1.2 × 1014 L⊙), making them some of the most luminous galaxies found so far. They are also some of the rarest objects in the sky with a source density of ≲0.01 deg−2. Our Atacama Large Millimeter/submillimeter Array 1.1 mm continuum observations with θ ≈ 0.4 arcsec resolution show clear ring or arc morphologies characteristic of strong lensing. Their lensing-corrected luminosity of L IR ≳ 1013 L⊙ (star-formation rate ≳ 103 M⊙ yr−1) indicates that they are the magnified versions of the most intrinsically luminous DSFGs found at these redshifts. Our spectral energy distribution analysis finds little detectable active galactic nucleus (AGN) activity despite their enormous luminosity, and any AGN activity present must be extremely heavily obscured. [ABSTRACT FROM AUTHOR]

As part of the Early Science Large Millimeter Telescope projects, we report the detection of nine double-peaked molecular lines, produced by a rotating molecular torus, in the ultraluminous infrared galaxies (ULIRG) – Compton-thick active galactic nuclei (AGN) galaxy UGC 5101. The double-peaked lines we report correspond to molecular transitions of HCN, HCO+, HNC, N2H+, CS, C18O, 13CO, and two CN lines; plus the detection of C2H that is a blend of six lines. The redshift search receiver spectra covers the 73–113 GHz frequency window. Low- and high-density gas tracers of the torus have different implied rotational velocities, with a rotational velocity of 149 ± 3  km s−1 for the low-density ones (C18O, 13CO) and 174 ± 3  km s−1 for high-density tracers (HCN, HCO+, HNC, N2H+, CS, and CN). In UGC 5101, we find that the ratio of integrated intensities of HCN to 13CO to be unusually large, probably indicating that the gas in the torus is very dense. Both the column densities and abundances are consistent with values found in AGN, starburst, and ULIRG galaxies. The observed abundance ratios cannot discriminate between X-ray and UV-field-dominated regions. [ABSTRACT FROM AUTHOR]

Extremely high velocity emission, likely related to jets, is known to occur in some protoplanetary nebulae. However, the molecular complexity of this kinematic component is largely unknown. We observed the known extreme outflow from the protoplanetary nebula IRAS 16342-3814, a prototype water fountain, over the full frequency range from 73111 GHz with the Redshift Search Receiver (RSR) on the Large Millimetre Telescope. We detected the molecules SiO, HCN, SO and 13CO. All molecular transitions, with the exception of the latter, are detected for the first time in this source and all present emission with velocities up to a few hundred km s-1. IRAS 16342-3814 is therefore the only source of this kind presenting extreme outflow activity in all these molecules simultaneously, with SO and SiO emission showing the highest velocities found for these species in protoplanetary nebulae. A tentative weak SO component with a full width at half-maximum of ~700 km s-1 remains to be confirmed. The extreme outflow gas consists of dense gas (nH2 > 104.8-105.7 cm-3) with a mass larger than ~ 0.02-0.15 Mʘ. The relatively high abundances of SiO and SO may be an indication of oxygen-rich extremely high velocity gas. [ABSTRACT FROM AUTHOR]

We present 8.5 arcsec resolution 1.1-mm continuum imaging and CO spectroscopic redshift measurements of eight extremely bright submillimetre galaxies identified from the Planck and Herschel surveys, taken with the Large Millimeter Telescope's AzTEC and Redshift Search Receiver instruments. We compiled a candidate list of high-redshift galaxies by cross-correlating the Planck Surveyor mission's highest frequency channel (857 GHz, full width at half-maximum = 4.5 arcmin) with the archival Herschel Spectral and Photometric Imaging Receiver imaging data, and requiring the presence of a unique, single Herschel counterpart within the 150-arcsec search radius of the Planck source positions with 350-μm flux density larger than 100 mJy, excluding known blazars and foreground galaxies. All eight candidate objects observed are detected in 1.1 mm continuum by AzTEC bolometer camera, and at least one CO line is detected in all cases with a spectroscopic redshift between 1.3 < zCO < 3.3. Their infrared (IR) spectral energy distributions (SEDs) mapped using the Herschel and AzTEC photometry are consistent with cold dust emission with characteristic temperature between Td = 43 and 84 K. With apparent IR luminosity of up to LIR = 3 × 1014μ−1 L⊙, they are some of the most luminous galaxies ever found (with yet unknown gravitational magnification factor μ). The analysis of their SEDs suggests that star formation is powering the bulk of their extremely large IR luminosities. Derived molecular gas masses of MH2=(0.6−7.8)×1011M⊙ (for μ ≈ 10) also make them some of the most gas-rich high-redshift galaxies ever detected. [ABSTRACT FROM AUTHOR]

Measuring redshifted CO line emission is an unambiguous method for obtaining an accurate redshift and total cold gas content of optically faint, dusty starburst systems. Here, we report the first successful spectroscopic redshift determination of AzTEC J095942.9+022938 ('COSMOS AzTEC-1'), the brightest 1.1 mm continuum source found in the AzTEC/James Clerk Maxwell Telescope survey (Scott et al.), through a clear detection of the redshifted CO (4-3) and CO (5-4) lines using the Redshift Search Receiver on the Large Millimeter Telescope. The CO redshift of z = 4.3420 ± 0.0004 is confirmed by the detection of the redshifted 158 μm [C II] line using the Submillimeter Array. The new redshift and Herschel photometry yield LFIR = (1.1 ± 0.1) × 1013 L⊙ and SFR ≈ 1300 M⊙ yr−1. Its molecular gas mass derived using the ultraluminous infrared galaxy conversion factor is 1.4 ± 0.2 × 1011M⊙ while the total interstellar medium mass derived from the 1.1 mm dust continuum is 3.7 ± 0.7 × 1011M⊙ assuming Td = 35 K. Our dynamical mass analysis suggests that the compact gas disc (r ≈ 1.1 kpc, inferred from dust continuum and spectral energy distribution analysis) has to be nearly face-on, providing a natural explanation for the uncommonly bright, compact stellar light seen by the HST. The [C II] line luminosity L[C II]=7.8±1.1×109L⊙ is remarkably high, but it is only 0.04 per cent of the total IR luminosity. AzTEC COSMOS-1 and other high redshift sources with a spatially resolved size extend the tight trend seen between [C II]/FIR ratio and ΣFIR among IR-bright galaxies reported by Díaz-Santos et al. by more than an order of magnitude, supporting the explanation that the higher intensity of the IR radiation field is responsible for the '[C II] deficiency' seen among luminous starburst galaxies. [ABSTRACT FROM AUTHOR]

The efficacy of verapamil in a dose of 120 mg thrice daily was assessed by an objective protocol. Twenty-five patients with ischaemic heart disease were subjected to serial, measured multistage treadmill exercise without any drugs, and after propranolol 40 mg t.d.s. for 3 days to assess the stress response to beta-blockade. The tests were repeated after 2, 4 and 8 weeks of verapamil. The assessment was based on computerized ST segment changes, the anginal threshold and other objective parameters. Verapamil rendered eight out of thirteen symptomatic patients pain free and significantly increased the anginal threshold in all others. The ischaemic response as assessed by the ST segment changes on exercise showed a marked improvement in the symptomatic as well as the asymptomatic groups. No major side effects were encountered throughout the study. It was concluded that verapamil in a dose of 360 mg/day is an effective antianginal agent free from significant side effects. [ABSTRACT FROM PUBLISHER]