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The repair of DNA double-strand breaks is a crucial yet delicate process which is affected by a multitude of factors. In this study, our goal is to analyse the influence of the linear energy transfer (LET) on the DNA repair kinetics. By utilizing the database of repair of DNA and aggregating the results of 84 experiments, we conduct various model fits to evaluate and compare different hypothesis regarding the effect of LET on the rejoining of DNA ends. Despite the considerable research efforts dedicated to this topic over the past decades, our findings underscore the complexity of the relationship between LET and DNA repair kinetics. This study leverages big data analysis to capture overall trends that single experimental studies might miss, providing a valuable model for understanding how radiation quality impacts DNA damage and subsequent biological effects. Our results highlight the gaps in our current understanding, emphasizing the pressing need for further investigation into this phenomenon. [ABSTRACT FROM AUTHOR]

The Mayo Clinic Florida microdosimetric kinetic model (MCF MKM) is a recently developed clonogenic survival model. Since the MCF MKM relies on novel strategies to a priori determine the cell-specific model parameters, the only experiment-specific input values are the α and ß terms of the linear–quadratic model (LQM) of clonogenic survival for the reference photon exposure. Because the two LQM terms are anti-correlated, the fitting process of the reference photon survival curve was found to significantly influence the MCF MKM calculations. This article reports this effect for two clinically relevant cell lines (human brain glioblastoma A-172, human healthy foreskin fibroblasts AG01522) and ions (1H and 12C ions). [ABSTRACT FROM AUTHOR]

After a short review of the achievements of the Microdosimetric d(z) Model in describing and predicting the response of luminescent detectors for different exposure conditions, recent comments and suggestions are systematically addressed also in light of more recent findings. [ABSTRACT FROM AUTHOR]

Using a recently developed microdosimetric model based on the Monte Carlo code PHITS, the relative luminescence efficiency of LiF:Mg,Cu,P (MCP) thermoluminescent detectors to charged particles from 1H to 132Xe with energies from 3 to 1000 MeV/u has been assessed. The results have been compared with literature data showing very good agreement for particles from 12C to 132Xe in case of model calculations performed in a site size of 40 nm. For 1H and 4He ions, the model overestimates the experimental values by ~10%. An explanation of this deviation as a consequence of fading effects has been included. [ABSTRACT FROM AUTHOR]

A microdosimetric model has been developed to predict the relative efficiency of luminescent detectors for measuring different radiation qualities. The model has been tested for LiF:Mg,Ti (MTS) detectors exposed to charged particles from 1H to 132Xe in the energy range 3–1000 MeV/u. The obtained results have been compared with experimental data present in literature showing very good agreement in case of calculations performed in a site size of 40 nm. [ABSTRACT FROM AUTHOR]