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In this article, the authors focus on the effect of medium-chain fatty acids (MCFAs) on the excretion of cholic acid and fecal cholesterol in C57BL/6J mice fed with a cholesterol-rich diet. They inform that low-density lipoprotein cholesterol and blood total cholesterol levels have been reduced as compared to diet with stearic acid, when the mice was given diet rich in caprylic acid for 12 weeks. They mention that excretion of fecal bile acids has been increased by MCFAs.

The article presents a study that investigates the influence of medium-chain triglyceride (MCT) on the increasing activity and expression of hormone-sensitive lipase (HSL) in white adipose tissue (WAT) in C57BL/6J mice. It notes that the possible mechanism has been assessed by analyzing the changes in blood lipid profile, enzymatic level and protein kinase. It further highlights the importance of adipose triglyceride lipase (ATGL) on the hydrolysis of stored glycerides.

The article presents a study that aims to determine the effectiveness of medium and long-chain triacylglycerols (MLCT) oil in lowering the level of triglyceride (TG) in the blood of hypertriglyderidemic Chinese with age of less and more than 60 years. The study involves Chinese patients with hypertriglyceridemia from 1.7 to 4.5 mmol/l and with more than 22kg/m2 body mass index (BMI). Results show that the levels of TG in patients less than 60 years old were lower in MLCT group.