1. Metabolic implications of GH treatment in small for gestational age.
- Author
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Delemarre, E. M., Rotteveel, J., and de Waal, H. A. Delemarre-van
- Subjects
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GESTATIONAL age , *SOMATOTROPIN , *METABOLISM , *FETAL growth retardation , *INSULIN resistance , *CARDIOVASCULAR diseases , *SOMATOMEDIN - Abstract
Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catchup growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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