1. Compositional analysis of microbiome data using the linear decomposition model (LDM).
- Author
-
Hu, Yi-Juan and Satten, Glen A
- Subjects
- *
DATA analysis , *EXPERIMENTAL design - Abstract
Summary There are compelling reasons to test compositional hypotheses about microbiome data. We present here linear decomposition model-centered log ratio (LDM-clr), an extension of our LDM approach to allow fitting linear models to centered-log-ratio-transformed taxa count data. As LDM-clr is implemented within the existing LDM program, this extension enjoys all the features supported by LDM, including a compositional analysis of differential abundance at both the taxon and community levels, while allowing for a wide range of covariates and study designs for either association or mediation analysis. Availability and implementation LDM-clr has been added to the R package LDM, which is available on GitHub at https://github.com/yijuanhu/LDM. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF