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Aims: This work is aiming at investigating algicidal characterization of a bacterium isolate DHQ25 against harmful alga Alexandrium tamarense. Methods and Results: 16S rDNA sequence analysis showed that the most probable affiliation of DHQ25 belongs to the γ-proteobacteria subclass and the genus Vibrio. Bacterial isolate DHQ25 showed algicidal activity through an indirect attack. Xenic culture of A. tamarense was susceptible to the culture filtrate of DHQ25 by algicidal activity assay. Algicidal process demonstrated that the alga cell lysed and cellular substances released under the visual field of microscope. DHQ25 was a challenge controller of A. tamarense by the above characterizations of algicidal activity assay and algicidal process. Conclusion: Interactions between bacteria and harmful algal bloom (HAB) species proved to be an important factor regulating the population of these algae. Significance and Impact of Study: This is the first report of a Vibrio sp . bacterium algicidal to the toxic dinoflagellate A. tamarense. The findings increase our knowledge of the role of bacteria in algal-bacterial interaction. [ABSTRACT FROM AUTHOR]

Werner syndrome (WS) is an autosomal recessive inherited disease characterized by features of premature ageing. It is caused by mutations of the WRN gene encoding a protein with both exonuclease and helicase activities. The aim of this study was to identify gene mutations in a Chinese patient with WS. A 31-year-old Chinese man with typical features of WS was diagnosed as having probable WS. We performed PCR to scan 33 exons of the WRN gene of the patient, six members of his family, and 50 unrelated controls. Automated DNA sequencing identified the mutation in the patient as 3250delG. The proband’s parents, son, younger brother and paternal grandmother were heterozygous. We did not find this heterozygous mutation in the proband’s maternal grandmother or in any of 50 normal controls. The novel mutation in the WRN gene is responsible for the pathogenesis of WS and genetic detection is a useful method to confirm the diagnosis. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 38-year-old man diagnosed with unilateral eccrine chromhidrosis. Among the laboratory investigations are platelet count, urinalysis, and complete blood count. It notes that botulinum toxin type A injections or capsaicin cream were found effective for chromhidrosis treatment.