1. Does PSA level affect the choice of prostate puncture methods among MRI-ultrasound fusion targeted biopsy, transrectal ultrasound systematic biopsy or the combination of both?
- Author
-
Liu, Yunyun, Dong, Lin, Xiang, Lihua, Zhou, Boyang, Wang, Hanxiang, Zhang, Ying, Xu, Guang, Wu, Jian, Wang, Shuai, Zhang, Yifeng, and Xu, Huixiong
- Subjects
ENDORECTAL ultrasonography ,PROSTATE-specific antigen ,PROSTATE ,BIOPSY ,HISTOPATHOLOGY ,PROSTATE cancer - Abstract
To explore whether prostate-specific antigen (PSA) affects the choice of prostate puncture methods by comparing MRI-ultrasound fusion targeted biopsy (MRI-TBx) with transrectal ultrasound systematic biopsy (TRUS-SBx) in the detection of prostate cancer (PCa), clinically significant prostate cancer (csPCa) and non-clinically significant prostate cancer (nsPCa) in different PSA groups (<10.0,10.0–20.0 and>20.0 ng ml
−1 ). A total of 190 patients with 215 lesions who underwent both MRI-TBx and TRUS-SBx were included in this retrospective study. PSA was measured pre-operatively and stratified to three levels. The detection rates of PCa, csPCa and nsPCa through different methods (MRI-TBx, TRUS-SBx, or MRI-TBx +TRUS SBx) were compared with stratification by PSA. Among the 190 patients, the histopathological results revealed PCa in 126 cases, including 119 csPCa. In PSA <10.0 ng ml−1 group, although the detection rates of PCa and csPCa by MRI-TBx were higher than those of TRUS-SBx, no significant differences were observed (p = 0.741; p = 0.400). In PSA 10.0–20.0 ng ml−1 group, difference between the detection rate of csPCa with TRUS-SBx and the combined method was statistically significant (p = 0.044). As for PSA >20.0 ng ml−1 , MRI-TBx had a higher csPCa rate than TRUS-SBx with no statistical significance noted (p = 0.600). MRI-TBx combined with TRUS-SBx could be suitable as a standard detection approach for csPCa in patients with PSA 10.0–20.0 ng ml−1 . As for PSA >20.0 and <10.0 ng ml−1 , both MRI-TBx and TRUS-SBx might provide effective solutions for tumor detection. This study gives an account of choosing appropriate prostate puncture methods through PSA level. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF