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INTROUDCTION Bullous pemphigoid (BP) is a common autoimmune bullous disease generally occurring in elderly patients. Itchy and tense blisters on normal skin or erythematous and edematous lesions on the trunk and extremities usually characterize BP. Trigger factors are still unclear while several case reports suggest a potential role of radiotherapy (RT) as BP trigger for disease onset or recrudescence. A review was performed in order to provide an update of literature. A case report of a patient affected by BP undergoing two radiotherapy courses for a primary breast cancer was also reported. MATERIALS AND METHODS A comprehensive review of the published literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The review included studies describing BP and its relationships with RT treatments. RESULTS A total of 13 articles were reviewed. Studies characteristics analysis resulted in eleven case reports, one case series and one large-scale case–control study. CONCLUSIONS Literature update confirms the existence of a reasonable connection between RT and BP. Case report showed that a multidisciplinary management seems to assure the feasibility of RT in patients affected by BP, not depriving them of standard therapeutic opportunities.

Several microalgae of the genus Alexandrium (Alexandrium minutum and Alexandrium catenelle) can produce an algal biotoxin, the paralytic shellfish poison (PSP) that can be accumulated in the shellfish edible tissues making them hazardous to the consumer’s health. In this paper we report i) the results of PSP toxins survey carried out by mouse bioassays (mouse test AOAC 958.08) on 7457 samples of bivalve molluscs farmed in Sardinia and in other European countries and marketed in Sardinia region from 2002 to 2011, and ii) the management of positive cases. Based on our experience it is very important to strictly apply the planned activities in order to prevent any risk and to protect the consumer’s and producer’s health.