1. Analysis of liver function test abnormalities in kidney transplant recipients: 7 year experience
- Author
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Aksoy S, Abdulmecit Yildiz, Oguzhan Sitki Dizdar, Alparslan Ersoy, Ozel Coskun Bd, Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı., Ersoy, Alparslan, Aksoy, Savaş, Yıldız, Abdülmecit, J-1232-2013, and AAH-5054-2021
- Subjects
Male ,Aspartate aminotransferase blood level ,Unclassified drug ,Cytomegalovirus ,Gamma glutamyl transferase blood level ,030230 surgery ,Hepatitis ,Kidney transplantation ,chemistry.chemical_compound ,0302 clinical medicine ,Liver ,Autoimmune Hepatitis ,Infliximab ,Cholelithiasis ,Observational study ,Cyclosporin a ,Azathioprine ,medicine.diagnostic_test ,Antibiotic agent ,Incidence ,Incidence (epidemiology) ,Mycophenolate mofetil ,Drugs ,Lactate dehydrogenase ,Renal-allograft recipients ,General Medicine ,Hepatitis B ,Medicine, general & internal ,Retrospective study ,Hyperlipidemia ,Cytokine receptor antagonist ,Creatinine ,Liver function test ,Cyclosporine ,Original Article ,Alanine aminotransferase blood level ,Female ,030211 gastroenterology & hepatology ,Human ,Adult ,medicine.medical_specialty ,Gamma glutamyltransferase ,Liver toxicity ,Prednisolone ,Major clinical study ,Aspartate aminotransferase ,Tacrolimus ,Article ,Mycophenolatemofetil ,03 medical and health sciences ,Acute graft rejection ,Sepsis ,Internal medicine ,Alkaline phosphatase ,medicine ,Everolimus ,Rapamycin ,Creatinine blood level ,Risk factor ,Sirolimus ,business.industry ,Hepatotoxicity ,medicine.disease ,Mortality rate ,Cotrimoxazole ,Acute pancreatitis ,Discontinuation ,Interleukin 2 receptor antagonist ,Cyclosporin A ,Immunoglobulin M ,Lactate dehydrogenase blood level ,chemistry ,Alanine aminotransferase ,Alkaline phosphatase blood level ,Graft recipient ,Graft-rejection ,Therapy ,General & internal medicine ,Liver function tests ,business ,Complication ,Controlled study - Abstract
Objective: Immunosuppressive drugs, antimicrobial agents and infectious complications may cause liver function test abnormalities (LFTA) in kidney transplant recipients (KTR). The objectives of this study were to identify the outcome of (LFTA). To identify the risk factors affecting development and severity of hepatotoxicity in KTR. Methods: We retrospectively evaluated the medical records of KTR. Hepatotoxicity attacks were defined as impairment in liver function tests that was responsive to drug dose reduction or discontinuation, or treatment of specific causes such as infectious complications. Results: One hundred-fifty-six episodes of hepatotoxicity occurred in 107 patients in 281 KTR, with an incidence of 38%. Patients with hepatotoxicity episodes had a high total mortality rate, higher incidence of positive pre-transplant cytomegalovirus (CMV) IgM test, higher creatinine values during the first month post-transplant, underwent additional acute rejection episodes, and received fewer cyclosporin A based ID. Only positive CMV IgM testing was identified as a significant independent risk factor for hepatotoxicity in our multiple analysis. Mycophenolatemofetil (MMF) related hepatotoxicity was the most common cause of drug related LFTA. Conclusions: Patients with LFTA can have significant complications. Pre-transplant positive CMV IgM tests predispose transplant recipients to the development of LFTA during the post-transplant period. MMF can be a serious hepatotoxic drug.
- Published
- 2016
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