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Background: This study was designed to determine the use of bifurcated and not reversed saphenous vein in different cases., Case Description: We report two cases treated in the department of vascular surgery (Busto Arsizio, Varese, Italy) in which different arterial tracts had to be revascularized at the same time using not reversed autologus greater bifurcated saphenous vein. They are two different clinical situations (infection and very distal revascularization) treated by the same surgical technique. The two patients were subjected to angiographic examination in the pre- and postoperative period. During their follow-up, we carried out noninvasive surveillance (Doppler c.w.). The second were also subjected to bacterial culture and antibiogram to establish an adequate antibiotic therapy. The mean follow-up was 22 months: during this period rest pain disappeared and the trophic lesion recovered., Conclusions: In our experience, the use of not reversed and bifurcated vein was haemodynamically valid and able to maintain an arterial blood flow on the receiving arteries.