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Several studies have been conducted by antioxidant properties of the Beta-carotenes in relation to their ability like prevention to coronary diseases. Similarly, 3 out of 4 randomized studies have shown that higher intakes or higher blood concentrations of β-carotenes are associated with the reduced risk of the Predictive Heart Disease (PHD). As vitamin A functions as an epithelial membrane regulator and provides immunity. In spite beta-carotene is the precursor of the vitamin A in the body, which also shows proportional relation to the body vitamin A concentration. However, beta-carotene is mostly addressing through its antioxidant properties. Similarly, a direct relation to the PHD by the pupil response effected by the pro-vitamin A have not been studied.