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Biological evaluation of the quality and safety of food, feed and environmental objects is a highly sensitive, informative test with high productivity, which does not require complicated equipment and large material costs. Biological evaluation is impeccable from the ethical point of view. Biotesting allows to give an integral assessment of the object taking into account the impact on it of various toxic compounds present in the environment. At present, the possibility of using biotesting to assess the quality and safety of honey and bee products has not been studied. At the same time, the use of biotests alternative to higher animals makes it possible to study the mechanisms of action of this complex product on the body, to assess the risks of uncontrolled application of honey and bee products.