1. Molecular genetics and clinical applications for RH.
- Author
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Flegel WA
- Subjects
- Alleles, Erythroblastosis, Fetal diagnosis, Erythroblastosis, Fetal economics, Erythroblastosis, Fetal genetics, Erythroblastosis, Fetal prevention & control, Ethnicity genetics, Evolution, Molecular, Female, Fetal Blood chemistry, Forecasting, Gene Duplication, Gene Frequency, Genotype, Humans, Maternal-Fetal Exchange, Models, Molecular, Mutation, Phenotype, Pregnancy, Prenatal Diagnosis, Protein Conformation, Rh-Hr Blood-Group System chemistry, Rh-Hr Blood-Group System physiology, Transfusion Reaction, Blood Grouping and Crossmatching economics, Blood Grouping and Crossmatching methods, Blood Transfusion, Chromosomes, Human, Pair 1 genetics, Molecular Diagnostic Techniques economics, Rh-Hr Blood-Group System genetics
- Abstract
Rhesus is the clinically most important protein-based blood group system. It represents the largest number of antigens and the most complex genetics of the 30 known blood group systems. The RHD and RHCE genes are strongly homologous. Some genetic complexity is explained by their close chromosomal proximity and unusual orientation, with their tail ends facing each other. The antigens are expressed by the RhD and the RhCE proteins. Rhesus exemplifies the correlation of genotype and phenotype, facilitating the understanding of general genetic mechanisms. For clinical purposes, genetic diagnostics of Rhesus antigens will improve the cost-effective development of transfusion medicine., (Published by Elsevier Ltd.)
- Published
- 2011
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