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Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Sarah Dyball reports a relationship with Novartis Pharmaceuticals that includes: funding grants. Sarah Dyball reports a relationship with UCB Inc. that includes: funding grants. Sarah Dyball reports a relationship with Eli Lilly and Company that includes: funding grants. Anastasia-Vasiliki Madenidou reports a relationship with UCB Inc. that includes: travel reimbursement. Anastasia-Vasiliki Madenidou reports a relationship with Janssen Pharmaceuticals Inc. that includes: funding grants and travel reimbursement. Ian Bruce reports a relationship with Janssen Pharmaceuticals Inc. that includes: funding grants. Ian Bruce reports a relationship with Sanofi that includes: funding grants. Ian Bruce reports a relationship with GSK that includes: consulting or advisory, funding grants, and speaking and lecture fees. Ian Bruce reports a relationship with Roche that includes: funding grants. Ian Bruce reports a relationship with UCB Inc. that includes: consulting or advisory, funding grants, and speaking and lecture fees. Ian Bruce reports a relationship with AstraZeneca Pharmaceuticals LP that includes: consulting or advisory and speaking and lecture fees. Ian Bruce reports a relationship with Eli Lilly and Company that includes: consulting or advisory. Ian Bruce reports a relationship with Merck & Co Inc. that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.