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Background: General practitioners experience a high workload during out-of-hours care. A possible solution is the shifting of care to nurse practitioners., Objectives: To provide insight into patient- and care characteristics, safety, efficiency, and patient satisfaction of substituting general practitioners with nurse practitioners for home visits by out-of-hours primary care services., Design: Quasi-experimental non-randomised study comparing home visits by nurse practitioners (intervention group; one out-of-hours care service) with home visits by general practitioners (control group; two out-of-hours care services) for 24 protocolised health problems., Setting: Three out-of-hours primary care services in the East of the Netherlands., Participants: 1601 patients who received a home visit by a nurse practitioner (N = 386) or a general practitioner (N = 1215). Of these patients, 639 gave informed consent to be included in the protocol adherence assessment and follow-up record review (nurse practitioner: N = 358; general practitioner: N = 281)., Methods: Five nurse practitioners with experience in ambulance care were recruited and trained. From September 2016 to March 2017 the nurse practitioners took over home visits under supervision of a general practitioners. This was evaluated using: (1) data-extraction from the patient registration system, (2) follow-up record review in the patients' general practices, and (3) patient satisfaction survey. Two general practitioners independently assessed protocol adherence based on the extracted registration data., Results: Nurse practitioners prescribed medication significantly less often than general practitioners (19.9% versus 30.6%), and referred patients significantly more often to the hospital (24.1% versus 15.9%). The mean length of the home visit was significantly longer for nurse practitioners (34.1 versus 21.1 min). Nurse practitioners adhered to the protocol significantly more often than general practitioners (84.9% versus 76.2%) and their medication prescribing was significantly more often appropriate (93.7% versus 79.5%). There were no differences in the number of missed diagnoses and complications. The number of follow-up contacts was also similar in both groups. Patient satisfaction was generally high and significantly higher for nurse practitioners on several items., Conclusions: Nurse practitioners with experience in ambulance care can safely, efficiently, and satisfactorily perform low complex out-of-hours primary care home visits. It is recommended to study the safety and efficiency of nurse practitioners' home visits in other regions and with nurse practitioners with different educational levels and different specialisations. In addition, we recommend to evaluate the cost-effectiveness and if it leads increased quality of care., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Several lines of evidence indicate that people with Parkinson's disease are impaired at detecting their own motor errors. In the present study, we use a component of the event-related brain potential called the error-related negativity (ERN) to ask whether a high-level, generic error-processing system is compromised in Parkinson's disease. We recorded the electroencephalogram (EEG) from nine patients with mild to moderate Parkinson's disease and from nine normal control subjects while they performed a choice reaction time task. We found that the amplitude of the ERN was the same for both populations, indicating that the error-processing system associated with the ERN is not severely compromised in this Parkinson's disease population. These results are discussed in terms of disease progression.