1. FORMULATION AND DEVELOPMENT OF BIFONAZOLE MICROEMULSION BASED GEL FOR TOPICAL DRUG DELIVERY BY USING DESIGN OF EXPERIMENT.
- Author
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Thummar, Bhautik, Patel, Mansi, Shah, Chainesh, and Upadhyay, U. M.
- Subjects
MICROEMULSIONS ,BIFONAZOLE ,TERNARY phase diagrams ,ZETA potential ,EXPERIMENTAL design ,DRUG delivery systems ,DRUG utilization - Abstract
Objective: Aim of present studies to reduce the particle size, increase the surface area with increase permeation of drug and modify release of drug at specific site hence dose and dose frequency may be decreased, thereby obtaining greater therapeutic efficacy. Experimental Work: Present study has been involved to prepare microemulsion of a poorly water-soluble drug, Bifonazole. Before the formulation of Bifonazole microemulsion, perform the Pre formulation study. Find out maximum solubility of Bifonazole in oils, surfactants and co-surfactants was evaluated to identify potential excipients. The microemulsion area were selected through the construction of the pseudo ternary phase diagrams by phase titration method. Results & Discussion: A 3² full factorial design was applied to examine the combined effect of two formulation variables, each at 3 levels and the possible 9 combinations of Bifonazole ME were prepared. Optimized ME was prepared and incorporated into gelling agent added as gel matrix to convert microemulsion into microemulgel. Microemulsion and microemulgel evaluated by %transmittance, viscosity, pH, Density, conductivity, TEM, particle size, Zeta potential, surface tension, refractive index, In-vitro diffusion study. Physical appearance, viscosity, spread ability, extrudability measurement, syneresis measurement, comparison with marketed product, antifungal activity and accelerated stability studies. From FTIR and DSC study found there is no interaction between drug and excipient. On the bases of pseudo ternary phase diagram has been found that the system consisting of capryol 90, tween 80 and PEG 400 showed good emulsifying property at Smix ratio 4:1. Microemulsion formulation F10 was optimized on the basis of %Transmittance, viscosity, %cumulative drug release (3 hrs). On the basis of physical examination viscosity, pH and spread ability result Diffusion Study, Sensitivity Study on animal and Kinetic Model Study of gel. Gel formulation was optimized batch that contains 1% carbopol as gelling agent. These above results indicate itraconazole loaded microemulgel drug delivery system may be promising vehicle for topical delivery of Bifonazole. [ABSTRACT FROM AUTHOR]
- Published
- 2023