1. Antimicrobial and antileishmanial studies of novel (2E)-3-(2-chloro-6-methyl/methoxyquinolin-3-yl)-1-(aryl)prop-2-en-1-ones.
- Author
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Rizvi SU, Siddiqui HL, Parvez M, Ahmad M, Siddiqui WA, and Yasinzai MM
- Subjects
- Anti-Infective Agents chemical synthesis, Anti-Infective Agents chemistry, Antiprotozoal Agents chemical synthesis, Antiprotozoal Agents chemistry, Crystallography, X-Ray, Dioxins chemical synthesis, Dioxins chemistry, Microbial Sensitivity Tests, Models, Molecular, Molecular Conformation, Parasitic Sensitivity Tests, Quinolines chemical synthesis, Quinolines chemistry, Stereoisomerism, Structure-Activity Relationship, Anti-Infective Agents pharmacology, Antiprotozoal Agents pharmacology, Dioxins pharmacology, Escherichia coli drug effects, Leishmania major drug effects, Micrococcus luteus drug effects, Quinolines pharmacology, Staphylococcus aureus drug effects
- Abstract
Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c-e, 1g, 1j-m, 1p, 1r-s, 2g, 2j-p, and 2r-s were found potentially active antileishmanial agents, while 1f-i, 1l, 1o-p, 2f-i, 2l, and 2o-p showed remarkable antibacterial activity. Only compounds 1g and 2g-h exhibited significant antifungal activity.
- Published
- 2010
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