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Your search keyword '"Kato, Keisuke"' showing total 23 results
Start Over Author "Kato, Keisuke" Publisher pharmaceutical society of japan
23 results on '"Kato, Keisuke"'

8. (17.ALPHA.,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic Acid Methyl Ester (YK11) Is a Partial Agonist of the Androgen Receptor

Author

Kanno, Yuichiro, primary, Hikosaka, Ritsuko, additional, Zhang, Shu-Yun, additional, Inoue, Yoshimi, additional, Nakahama, Takayuki, additional, Kato, Keisuke, additional, Yamaguchi, Akemi, additional, Tominaga, Nobuaki, additional, Kohra, Shinya, additional, Arizono, Koji, additional, and Inouye, Yoshio, additional

Published
2011
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21. The Antiarrhythmic Action of the Na + /Ca 2+ Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits.

Author

Kawakami S, Takada K, Aimoto M, Nagasawa Y, Kusakabe T, Kato K, and Takahara A

Subjects
Animals, Rabbits, Sodium-Calcium Exchanger, Anti-Arrhythmia Agents adverse effects, Verapamil adverse effects, Action Potentials, Atrioventricular Block chemically induced, Atrioventricular Block drug therapy, Long QT Syndrome chemically induced, Torsades de Pointes chemically induced, Torsades de Pointes drug therapy
Abstract

To clarify the pharmacological properties of the Na + /Ca 2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K + current (I Kr ) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 mg/kg) or high-dose nifekalant (3 mg/kg) prolonged the MAP duration (MAP 90 ) by 113 ± 11 ms (n = 5) and 237 ± 39 ms (n = 5), respectively, where TdP was induced in 1/5 animals treated with a low dose and in 3/5 animals treated with a high dose of nifekalant. In SEA0400-treated animals, low- and high-dose nifekalant prolonged the MAP 90 by 65 ± 13 ms (n = 5) and 230 ± 20 ms (n = 5), respectively. No TdP was induced by the low dose but 1/5 animals treated with a high dose of nifekalant developed TdP. In verapamil-treated animals, low-dose and high-dose nifekalant prolonged MAP 90 by 50 ± 12 ms (n = 5) and 147 ± 30 ms (n = 5), respectively, without inducing TdP. These results suggest that SEA0400 has the potential to inhibit low-dose nifekalant-induced TdP by suppressing the MAP-prolonging action of nifekalant, whereas the drug inhibited high-dose nifekalant-induced TdP without affecting the MAP-prolonging action of nifekalant. This may reveal that, in contrast to verapamil, the antiarrhythmic effects of SEA0400 on I Kr blocker-induced TdP may be multifaceted, depending on the severity of the proarrhythmogenic conditions present.

Published
2023
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22. Fluorescence Analysis of the Mitochondrial Effect of a Plasmalemmal Na + /Ca 2+ Exchanger Inhibitor, SEA0400, in Permeabilized H9c2 Cardiomyocytes.

Author

Namekata I, Hamaguchi S, Iida-Tanaka N, Kusakabe T, Kato K, Kawanishi T, and Tanaka H

Subjects
Calcium metabolism, Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone pharmacology, Cell Line, Cell Membrane drug effects, Clonazepam analogs & derivatives, Clonazepam pharmacology, Humans, Mitochondria, Heart metabolism, Myocytes, Cardiac drug effects, Ruthenium Red pharmacology, Thiazepines pharmacology, Aniline Compounds pharmacology, Cell Membrane metabolism, Mitochondria, Heart drug effects, Myocytes, Cardiac metabolism, Phenyl Ethers pharmacology, Sodium-Calcium Exchanger antagonists & inhibitors
Abstract

We investigated the effect on mitochondrial Ca 2+ of SEA0400, an inhibitor of the Na + /Ca 2+ exchanger (NCX) which reduces mitochondrial Ca 2+ overload during myocardial ischemia, in digitonin-permeabilized H9c2 cells expressing the mitochondrial-targeted Ca 2+ indicator, yellow cameleon 3.1. The elevation of mitochondrial Ca 2+ concentration caused by an increase in extramitochondrial Ca 2+ concentration was inhibited by carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) or ruthenium red, but enhanced by CGP-37157, a mitochondrial NCX inhibitor. SEA0400 had no effect on mitochondrial Ca 2+ under normal and ischemic conditions. Thus, the mitochondria-protective effects of SEA0400 could be explained by inhibition of plasmalemmal NCX but not mitochondrial NCX.

Published
2017
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23. Chemoenzymatic synthesis of n-hexyl and O-beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranosides.

Author

Kishida M, Nishiuchi M, Kato K, and Akita H

Subjects
Enzymes, Immobilized chemistry, Molecular Structure, beta-Glucosidase chemistry, Monosaccharides chemical synthesis, Xylose chemical synthesis
Abstract

Direct beta-glucosidation between 1,6-octanediol (5) and D-glucose (3) using the immobilized beta-glucosidase (EC 3.2.1.21) from almonds with the synthetic prepolymer ENTP-4000 gave a mono-beta-glucoside (6) in 61.4% yield, which was converted into the n-hexyl beta-D-glucopyranoside (1) by means of a chemoenzymatic method. The coupling of the n-hexyl beta-D-glucopyranoside congener (13) and 2,3,4-tri-O-acetyl-beta-D-xylosyl congener (14), followed by deprotection, afforded the synthetic n-hexyl O-beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranoside (2), which was identical to the natural 2 with respect to the spectral data and specific rotation.

Published
2004
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