1. Synthesis and Biological Activities of 2,6-Diaryl-3methyl-4-piperidone Derivatives
- Author
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Seshaiah Krishnan Sridhar, Natesh Rameshkumar, Anantharaman Veena, Mandaleeswaran Adiraj, R. Ilavarasan, and Pitchaimuthu Shanmugapandiyan
- Subjects
Pharmacology ,chemistry.chemical_classification ,Analgesics ,Antifungal Agents ,Ketone ,Ranidae ,biology ,Aspergillus niger ,Pharmaceutical Science ,General Medicine ,biology.organism_classification ,Oxime ,Acute toxicity ,Mice ,chemistry.chemical_compound ,chemistry ,Animals ,Organic chemistry ,Anesthetics, Local ,Candida albicans ,Mannich reaction ,Ammonium acetate ,Semicarbazone ,Piperidones ,Pain Measurement - Abstract
In the present study, a new series of 2,6-diaryl-3-methyl-4-piperidones was synthesized by Mannich reaction (condensation) of ethyl-methyl ketone, substituted aromatic aldehydes and ammonium acetate. Oximes and thiosemicarbazone derivatives of 2,6-diaryl-3-methyl-4-piperidones were synthesized by reaction with hydroxylamine hydrochloride and thiosemicarbazide respectively. The chemical structures were confirmed by means of IR, 1H-, 13C-NMR and mass spectral data. The compounds were screened for acute toxicity, analgesic, local anaesthetic and antifungal activity. 2-(4-Methylphenyl)-3-methyl-6-(4-chlorophenyl)-piperidin-4-one 2 exhibited the highest analgesic and local anaesthetic activity. The oximes and thiosemicarbazones were completely devoid of analgesic and local anaesthetic activity. 2-(4-Methylphenyl)-3-methyl-6-(4-hydroxyphenyl)-piperidin-4-oxime 21 and 2-(4-methoxyphenyl)-3-methyl-6-(4-chlorophenyl)-piperidin-4-oxime 17 exhibited potent antifungal activity against Aspergillus niger. Antifungal activity against Candida albicans was observed only with 2-(4-dimethylaminophenyl)-3-methyl-6-(4-chlorophenyl)-piperidin-4-oxime 20. 2,6-Diaryl-3-methyl-4-piperidones did not exhibit antifungal property.
- Published
- 2003