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Your search keyword '"Toshihiro Imaeda"' showing total 2 results
Start Over Author "Toshihiro Imaeda" Publisher pharmaceutical society of japan
2 results on '"Toshihiro Imaeda"'

1. Highly Stereoselective Synthesis and Structural Confirmation of a Fungal Metabolite, LL-P880.BETA

Author

Toshihiro Imaeda, Makoto Kawai, and Yukio Masaki

Subjects
chemistry.chemical_classification, Stereochemistry, Metabolite, Molecular Conformation, Penicillium, Enantioselective synthesis, Stereoisomerism, General Chemistry, General Medicine, Crystallography, X-Ray, chemistry.chemical_compound, Fungal metabolite, chemistry, Pyrones, Drug Discovery, Stereoselectivity, Derivative (chemistry), Lactone, Octane
Abstract

A fungal metabolite, LL-P880β [6S-(1'S, 2'R-dihydroxypentyl)-4-methoxy-5, 6-dihydropyran-2-one] (1), was synthesized unambiguously from diethyl (R, R)-tartrate (3) as a chiral pool via highly stereoselective construction of the C7'-asymmetric carbon of the intermediate 6, 8-dioxabicyclo[3.2.1]octane derivative (8a), and the stereochemistry of the C6-chiral center of the metabolite was chemically confirmed as (S).

Published
1994
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2. Synthesis of (+)-7-ethyl-5-methyl-6,8-dioxabicyclo(3.2.1)oct-3-ene, an optically active form of the house mouse pheromone

Author

Hiromu Nagashima, Hirohisa Oda, Yukio Masaki, Toshihiro Imaeda, and Ikuhiro Iwata

Subjects
Bridged-Ring Compounds, Chemical Phenomena, Bicyclic molecule, Stereochemistry, Enantioselective synthesis, Regioselectivity, General Chemistry, General Medicine, Tartrate, Bridged Bicyclo Compounds, Heterocyclic, Pheromones, Sulfone, Bridged Bicyclo Compounds, Chemistry, Mice, chemistry.chemical_compound, chemistry, Drug Discovery, Animals, Enantiomer, Ene reaction, Octane
Abstract

(+)-(1S, 5R, 7S)-7-Ethyl-5-methyl-6, 8-dioxabicyclo[3. 2. 1]oct-3-ene, an optically active form of the androgen-dependent pheromone of the adult male house mouse (Mus)___ (musculus)___, was synthesized from (+)-(R, R)-diethyl tartrate (via)___ highly site-selective olefination of the 6, 8-dioxabicyclo[3. 2. 1]octane intermediate.

Published
1988
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