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Your search keyword '"Yoshikazu Hinohara"' showing total 4 results
Start Over Author "Yoshikazu Hinohara" Publisher pharmaceutical society of japan
4 results on '"Yoshikazu Hinohara"'

2. Metabolic Fate of Eprazinone Hydrochloride. I. Absorption, Distribution, and Excretion of Eprazinone Hydrochloride in Vivo

Author

Yasuo Tohira, Shigeru Takanashi, Yoshikazu Hinohara, Hideki Nakano, Akira Sakuma, Hiroshi Kamiyama, Shozabro Ogiya, and Hidetaka Suzuki

Subjects
Pharmacology, Excretion, Chromatography, Eprazinone hydrochloride, Chemistry, In vivo, Pharmaceutical Science, Distribution (pharmacology), Absorption (electromagnetic radiation)
Published
1975
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3. A radioimmunoassay for MC-838 (altiopril calcium), a novel angiotensin-converting enzyme inhibitor

Author

Katsumi Wakabayashi, Yoshikazu Hinohara, and Sadao Tanaka

Subjects
Pharmacology, Antiserum, medicine.medical_specialty, Chromatography, Proline, biology, Chemistry, Coefficient of variation, Radioimmunoassay, Serum albumin, Reproducibility of Results, chemistry.chemical_element, Angiotensin-Converting Enzyme Inhibitors, Angiotensin-converting enzyme, Calcium, Dogs, Endocrinology, Pharmacokinetics, Enzyme inhibitor, Internal medicine, biology.protein, medicine, Animals, Rabbits
Abstract

A radioimmunoassay was developed for a new, potent inhibitor of angiotensin-converting enzyme (ACE; EC 3.4.15.1), calcium(-)-N-[(S)-3-[(N-cyclohexylcarbonyl-D-alanyl)thio]-2-methyl- propionyl]-L-prolinate (MC-838, altiopril calcium). The antiserum was obtained by immunizing rabbits with MC-838-bovine serum albumin (BSA) conjugate. MC-838-L-tyrosine labeled with 125I and purified by thin-layer chromatography was used as a tracer. The assay sensitivity was 0.1 ng/ml, the average intra-assay coefficient of variation was 7.9%, and the average inter-assay coefficient of variation was 13.7%. The antiserum was specific for MC-838, showing only slight crossreactivity with degradation products of MC-838. After a single oral dose of MC-838 (2 mg/kg), radioimmunoassay of MC-838 canine serum demonstrated rapid absorption from the gastrointestinal tract with a peak level of 40.6 ng/ml. The decline in serum concentration was a biphasic decay, with a half-life of 80 min during rapid falloff followed by a slower decline.

Published
1988
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4. Bioavailability of pyridoxal phosphate from enteric-coated tablets. I. Apparent critical dissolution pH and bioavailability of commercial products in humans

Author

Hidetaka Suzuki, Akira Okazaki, Shigeru Takanashi, Kazuo Igusa, Yoshikazu Hinohara, Hiroshi Kamiyama, Nobuo Aoyagi, Toshio Shibazaki, Nahoko Kaniwa, Hideki Nakano, Masanobu Koibuchi, Tadao Fujikura, Hiroyasu Ogata, Akira Ejima, and Sadao Bessho

Subjects
Adult, Male, Absorption (pharmacology), Chromatography, Enteric coated tablets, Biological Availability, General Chemistry, General Medicine, Hydrogen-Ion Concentration, Middle Aged, Bioequivalence, Enteric coating, Bioavailability, chemistry.chemical_compound, Solubility, chemistry, Pyridoxal Phosphate, Drug Discovery, medicine, Humans, Tablets, Enteric-Coated, Pyridoxal phosphate, Dissolution, medicine.drug
Abstract

The critical dissolution pH values for forty-eight enteric-coated tablets of pyridoxal phosphate (PAL-P) commercially available in Japan were determined by using an oscillating basket apparatus with buffers of various pH. The tablets were divided into three groups according to their critical dissolution pH (pH

Published
1985
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