1. In vitro and In vivo Immunomodulatory Activity of Hydro Ethanolic Extract of Grewia hirsuta Vahl.
- Author
-
Chikkamath, Vinuth, Kulkarni, Venkatrao, Habbu, Prasanna, and Nagappa, Anantha Naik
- Subjects
- *
LABORATORY mice , *COVID-19 pandemic , *NATURAL products , *EXTRACTS , *LYMPHOCYTES - Abstract
Background: The Advent of the COVID-19 pandemic has necessitated the quick exploration of new drugs. Synthetic approach is time consuming and expensive with uncertainty. The natural products can be explored as this approach is cost effective and takes less time to investigate. The ethnic significance of Grewia hirsuta has given clues of Immunomodulator potential. Hydro ethanolic extract of Grewia hirsuta was explored and compared with established levamisole. Materials and Methods: In vitro, immunomodulator models on human lymphocytes and In vivo carbon clearance model in Swiss albino mice were studied by lymphotoxicity and lymphocyte proliferation. Results: Hydro ethanolic extract of Grewia hirsuta has shown similar results of immunomodulation comparable with levamisole in statistically significant studies assessed by Dunnett's test. Conclusion: Hydro ethanolic extract has shown decreased lymphocyte toxicity and increased lymphocyte proliferation. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF