1. Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress
- Author
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Fu-Shi Quan, Dongxu Wang, Jia-Bao Zhang, Yong-Xun Jin, Siyi Huang, Mingjun Zhang, Wen-Zhi Ren, Jindong Hao, Wei Gao, and Xianfeng Yu
- Subjects
0301 basic medicine ,Embryology ,Swine ,Biophysics ,Cell Death & Injury ,Apoptosis ,medicine.disease_cause ,Biochemistry ,Andrology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Zoology & Marine Biology ,Oogenesis ,Gene expression ,Maturation ,medicine ,Hydroxyurea ,Animals ,Blastocyst ,Molecular Biology ,Research Articles ,chemistry.chemical_classification ,Reactive oxygen species ,Cumulus Cells ,Embryo ,Cell Biology ,Glutathione ,Oocyte ,In Vitro Oocyte Maturation Techniques ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Porcine oocyte ,Oocytes ,Female ,030217 neurology & neurosurgery ,Oxidative stress ,Developmental Biology - Abstract
Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus–oocyte complexes (COCs) to 20 µM (P
- Published
- 2021