Search

Your search keyword '"Imig, John D."' showing total 13 results
Start Over Author "Imig, John D." Publisher portland press ltd.
13 results on '"Imig, John D."'

3. Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Author

Neckář, Jan, primary, Hye Khan, Md. Abdul, additional, Gross, Garrett J., additional, Cyprová, Michaela, additional, Hrdlička, Jaroslav, additional, Kvasilová, Alena, additional, Falck, John R., additional, Campbell, William B., additional, Sedláková, Lenka, additional, Škutová, Šárka, additional, Olejníčková, Veronika, additional, Gregorovičová, Martina, additional, Sedmera, David, additional, Kolář, František, additional, and Imig, John D., additional

Published
2019
Full Text
View/download PDF

4. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats

Author

Sedláková, Lenka, primary, Kikerlová, Soňa, additional, Husková, Zuzana, additional, Červenková, Lenka, additional, Chábová, Věra Čertíková, additional, Zicha, Josef, additional, Falck, John R., additional, Imig, John D., additional, Kompanowska-Jezierska, Elzbieta, additional, Sadowski, Janusz, additional, Krátký, Vojtěch, additional, Červenka, Luděk, additional, and Kopkan, Libor, additional

Published
2018
Full Text
View/download PDF

7. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension

Author

Neckář, Jan, primary, Kopkan, Libor, additional, Husková, Zuzana, additional, Kolář, František, additional, Papoušek, František, additional, Kramer, Herbert J., additional, Hwang, Sung Hee, additional, Hammock, Bruce D., additional, Imig, John D., additional, Malý, Jiří, additional, Netuka, Ivan, additional, Ošťádal, Bohuslav, additional, and Červenka, Luděk, additional

Published
2012
Full Text
View/download PDF

8. Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertensioninduced end-organ damage in Ren-2 transgenic rats

Author

Chábová, Věra Čertíková, primary, Walkowska, Agnieszka, additional, Kompanowska-Jezierska, Elzbieta, additional, Sadowski, Janusz, additional, Kujal, Petr, additional, Vernerová, Zdenka, additional, Vaňourková, Zdeňa, additional, Kopkan, Libor, additional, Kramer, Herbert J., additional, Falck, John R., additional, Imig, John D., additional, Hammock, Bruce D., additional, Vaněčková, Ivana, additional, and Červenka, Luděk, additional

Published
2010
Full Text
View/download PDF

13. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.

Author

Kramer, Herbert J., Hwang, Sung Hee, Hammock, Bruce D., Imig, John D., Malý, Jiří, and Netuka, Ivan

Subjects
EPOXY compounds, HYDROLASES, BENZOIC acid, LABORATORY rats, ANGIOTENSIN II, HYPERTENSION
Abstract

The present study was undertaken to evaluate the effects of chronic treatment with c-AUCB {cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid}, a novel inhibitor of sEH (soluble epoxide hydrolase), which is responsible for the conversion of biologically active EETs (epoxyeicosatrienoic acids) into biologically inactive DHETEs (dihydroxyeicosatrienoic acids), on BP (blood pressure) and myocardial infarct size in male heterozygous TGR (Ren-2 renin transgenic rats) with established hypertension. Normotensive HanSD (Hannover Sprague–Dawley) rats served as controls. Myocardial ischaemia was induced by coronary artery occlusion. Systolic BP was measured in conscious animals by tail plethysmography. c-AUCB was administrated in drinking water. Renal and myocardial concentrations of EETs and DHETEs served as markers of internal production of epoxygenase metabolites. Chronic treatment with c-AUCB, which resulted in significant increases in the availability of biologically active epoxygenase metabolites in TGR (assessed as the ratio of EETs to DHETEs), was accompanied by a significant reduction in BP and a significantly reduced infarct size in TGR as compared with untreated TGR. The cardioprotective action of c-AUCB treatment was completely prevented by acute administration of a selective EETs antagonist [14,15-epoxyeicosa-5(Z)-enoic acid], supporting the notion that the improved cardiac ischaemic tolerance conferred by sEH inhibition is mediated by EETs actions at the cellular level. These findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension. [ABSTRACT FROM AUTHOR]

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results