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Background: COVID-19 restrictions and alterations to daily living (e.g. working from home, caregiving responsibilities) necessitated changes in physical activity (PA) behavior. Purpose: The purpose of this study is to understand how PA within specific domains and behavior settings changed during the COVID-19 pandemic. Methods: An e-survey, conducted April-June 2020, examined changes in PA across domains and settings in a national sample of adults (N=805; M age=38.7 ± 14.9 yrs; 78.0% female). Results: Respondents reported domain-specific increases in household and recreational PA, but decreases in active transportation, occupational PA, and public transportation use. Weekly minutes of PA changed significantly across all behavior settings, with reported increases in home-based, neighborhood, parks/trails, and total PA, and decreases in PA through recreational sports and fitness facilities. Total weekly PA minutes increased by 10.6% (Z= 4.428, p < .000). Those with caregiving responsibilities reported increases in household PA (2=9.82, p=0.007) and PA frequency (2=8.21, p=0.02). Those without caregiving responsibilities were more likely to report increases in sitting (2=20.55, p